Unraveling site-specific seed formation abnormalities in Mast. trees via widely metabolomic and transcriptomic analysis.

Mast. is a rare and threatened species of evergreen coniferous tree in China, commonly facing issues such as damaged seeds, abnormal seed growth, and empty seed shells. These abnormalities vary by location; unfortunately, the reasons behind these inconsistencies are completely unknown.

and adopt diverse response strategies to adapt to low-light conditions.

Introduction: In recent years, the visible light intensity of lawns has significantly decreased due to obstructions caused by urban shading objects. has a competitive advantage over other turfgrass in low-light conditions and extensive management. Therefore, exploring their survival strategy in low-light environments is of great significance.

GPR50 regulates neuronal development as a mitophagy receptor.

Neurons rely heavily on high mitochondrial metabolism to provide sufficient energy for proper development. However, it remains unclear how neurons maintain high oxidative phosphorylation (OXPHOS) during development. Mitophagy plays a pivotal role in maintaining mitochondrial quality and quantity.

Not only phosphorus: dauciform roots can also influence aboveground biomass through root morphological traits and metal cation concentrations.

Background: Phosphorus in the soil is mostly too insoluble for plants to utilize, resulting in inhibited aboveground biomass, while can maintain their aboveground biomass through the presence of dauciform roots. However, dauciform roots lead to both morphological and physiological changes in the root system, making their primary mechanism unclear.

Methods: A greenhouse experiment was conducted on three species, in which Al-P, Ca-P, Fe-P, and K-P were employed as sole phosphorus sources.

Dauciform roots affect the position of the neighboring plants on the economic spectrum in degraded alpine meadows.

Background And Aims: Special root structures that can dissolve insoluble phosphorus locked in soil are supposed to contribute not only to the growing status of themselves but also to the neighbouring plants. However, whether dauciform roots have any effect on the neighbouring plants and how does it respond to meadow degradation had not been studied.

Methods: Alpine meadows with different degradation statuses were selected and the functional traits of and the co-occurring species were measured to explore their response to degradation, as well as the response of to the dauciform roots of .

Recovering from trampling: The role of dauciform roots to functional traits response of in alpine meadow.

In the natural habitats of China, dauciform roots were only described in degraded alpine meadows. It was found that the presence of dauciform roots of was related to the advantage of multiple functional traits after trampling, reflecting short-term resistance. However, the long-term response of dauciform roots to trampling and the recovery of with and without dauciform roots to trampling require further studies.

Dauciform roots affect functional traits of Carex filispica under nitrogen and phosphorus fertilization in alpine meadow.

Over recent decades, there has been a severe nitrogen-deposition in alpine meadows which often leads to phosphorus limitation of plant productivity. In these high-altitude localities, Cyperaceae have an increasing biomass while other functional groups decrease. Meanwhile, Cyperaceae are known to have the ability of producing dauciform roots, which are formed under phosphorus limitation, but in China, are only described in these high-altitude places.

Response of to phosphorus deficiency and drought stress.

Introduction: The drought and phosphorus deficiency have inevitably become environmental issues globally in the future. The analysis of plants functional trait variation and response strategies under the stress of phosphorus deficiency and drought is important to explore their ability to respond to potential ecological stress.

Methods: In this study, was selected as the research object, and a 14-week pot experiment was conducted in a greenhouse, with two phosphorus treatment (add 0.

What role do dauciform roots play? Responses of to trampling in alpine meadows based on functional traits.

In China, dauciform roots were hardly studied and only reported in alpine meadows, where sedges showed a different tendency from other functional groups such as grasses and forbs with degradation. In addition, species were proved to have shifting scaling relationships among LES (leaf economics spectrum) traits under disturbance. So, are these unique performances of sedges related to the presence of dauciform roots, and if so, how? An alpine meadow dominated by in Baima Snow Mountain was selected, and quantitative trampling was performed (0, 50, 200, and 500 passes).

Ubiquitin-conjugating enzyme E2T promotes tumor stem cell characteristics and migration of cervical cancer cells by regulating the GRP78/FAK pathway.

Ubiquitin-conjugating enzyme E2T (UBE2T) functions as an E2 ubiquitin-conjugating enzyme in the ubiquitin-proteasome degradation system and mediates cellular processes, such as cell cycle, proliferation, and differentiation. UBE2T has been considered to be an oncogene in a variety of tumors. However, the oncogenic role of UBE2T in cervical cancer remains unclear.

Terahertz MIMO communication performance analysis in exponentiated Weibull turbulence with pointing errors.

With the rapid growth in demand for high-speed wireless communication, terahertz (THz) has become one of the most promising techniques. Both atmospheric turbulence and pointing errors are important factors in degrading the performance of THz propagation. We study the performance of a multiple-input/multiple-output (MIMO) system in the THz band under the combined influences noted above.

Prevalence of group B streptococcus colonization in pregnant women in Jiangsu, East China.

Background: Group B streptococcus (GBS) is the leading cause of early-onset neonatal sepsis. However, GBS was infrequently reported in the developing world in contrast to western countries. This study assessed the prevalence of GBS colonization among pregnant women in Jiangsu, East China, and revealed the difference of GBS infection between culture and PCR.

Intranasal Transplantation of Human Neural Stem Cells Ameliorates Alzheimer's Disease-Like Pathology in a Mouse Model.

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory impairments, which has no effective therapy. Stem cell transplantation shows great potential in the therapy of various disease. However, the application of stem cell therapy in neurological disorders, especially the ones with a long-term disease course such as AD, is limited by the delivery approach due to the presence of the brain blood barrier.

A case of catheter related bloodstream infection by .

Background: is an innocuous inhabitant of the normal human epithelial and mucosal surfaces. The s thogenic potential is increasingly recognized in our time.

Methods: We present a rare case of CRBSI by in a 57-yr-old male patient.

Transplantation of GABAergic Interneuron Progenitor Attenuates Cognitive Deficits of Alzheimer's Disease Model Mice.

Excitatory (E) and inhibitory (I) balance of neural network activity is essential for normal brain function and of particular importance to memory. Disturbance of E/I balance contributes to various neurological disorders. The appearance of neural hyperexcitability in Alzheimer's disease (AD) is even suggested as one of predictors of accelerated cognitive decline.

Functional ecology of congeneric variation in the leaf economics spectrum.

Variation in resource availability can lead to phenotypic plasticity in the traits comprising the world-wide leaf economics spectrum (LES), potentially impairing plant function and complicating the use of tabulated values for LES traits in ecological studies. We compared 14 Carex (Cyperaceae) species in a factorial experiment (unshaded/shaded × sufficient/insufficient P) to analyze how changes in the network of allometric scaling relationships among LES traits influenced growth under favorable and resource-limited conditions. Changes in leaf mass per area (LMA) shifted the scaling relationships among LES traits expressed per unit area vs mass in ways that helped to sustain growth under resource limitation.

Mitochondrial Dysfunction in Neural Injury.

Mitochondria are the double membrane organelles providing most of the energy for cells. In addition, mitochondria also play essential roles in various cellular biological processes such as calcium signaling, apoptosis, ROS generation, cell growth, and cell cycle. Mitochondrial dysfunction is observed in various neurological disorders which harbor acute and chronic neural injury such as neurodegenerative diseases and ischemia, hypoxia-induced brain injury.

Disrupted-in-schizophrenia-1 protects synaptic plasticity in a transgenic mouse model of Alzheimer's disease as a mitophagy receptor.

Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD). Accumulated damaged mitochondria, which are associated with impaired mitophagy, contribute to neurodegeneration in AD. We show levels of Disrupted-in-schizophrenia-1 (DISC1), which is genetically associated with psychiatric disorders and AD, decrease in the brains of AD patients and transgenic model mice and in Aβ-treated cultured cells.

Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1.

Sphingolipids emerge as essential modulators in the etiology of Alzheimer's disease (AD) with unclear mechanisms. Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer's disease (AD), where expression of β-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-β (Aβ) generation, are upregulated. In the present study, we show knockdown of SMS1 via andeno associated virus (serotype 8, AAV8) in the hippocampus of APP/PS1 transgenic mice, attenuates the densities of Aβ plaques, neuroinflammation, synaptic loss and thus rescuing cognitive deficits of these transgenic mice.

The relationship between the PD-1/PD-L1 pathway and DNA mismatch repair in cervical cancer and its clinical significance.

Background: According to recent clinical observations, deficient DNA mismatch repair (dMMR) is capable of improving antitumor effects of the PD-1/PD-L1 pathway, suggesting that dMMR may act as a prognostic indicator of PD-1/PD-L1 antibody drugs. In this study, we examined the dMMR and PD-1/PD-L1 expression, as well as explored the correlation of dMMR status with PD-1/PD-L1 expression in cervical cancer patients, in order to optimize cervical cancer patient selection for PD-1/PD-L1 antibody drug treatment, which is helpful to avoid adverse effects and keep costs manageable.

Methods: Sixty-six tissue samples from patients with squamous cell carcinoma were collected, and data of their clinical characteristics were also gathered.

Clinical treatment of malignant hyperthermia in three cases.

Malignant hyperthermia (MH) is a rare life threatening inherited disorder that is triggered by drugs used for general anesthesia in susceptible persons. The symptoms include rapid increase of body temperature and severe muscle contractions. The present study includes 3 cases of MH and highlights the timely identification of symptoms for rescuing the patient.

Treatment for patients with multidrug resistant pulmonary infection.

Bacterial infections are common but have become increasingly resistant to drugs. The aim of the present study was to examine the combined treatment of traditional Chinese and Western medicine in 30 cases of pulmonary infection with multidrug resistant . Patients were divided into groups A and B according to drug treatments.

Application strategy of PiCCO in septic shock patients.

Septic shock, also known as infectious or toxic shock, is a medical condition caused by severe infection and sepsis. Early identification, timely diagnosis and effective treatments are imperative to prevent this medical condition. The aim of the present study was to examine the application of pulse index continuous cardiac output (PiCCO) technique in the treatment of septic shock patients.

Clinical significance of plasma levels of brain natriuretic peptide and cardiac troponin T in patients with sepsis.

Sepsis is a systemic inflammatory response of the body to an antigen and can become a life-threatening condition by triggering a cascade of changes leading to multiple organ failure such as heart failure. The aim of the present study was to examine the changes of the plasma levels of N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in patients with sepsis and to analyze their prognostic significance. A total of 38 hospitalized patients with sepsis were included in the present study.