RNF13 protects neurons against ischemia-reperfusion injury via stabilizing p62-mediated Nrf2/HO-1 signaling pathway.

Background: Cerebral ischemia/reperfusion injury (CIRI), a common, universal clinical problem that costs a large proportion of the economic and disease burden. Identifying the key regulators of cerebral I/R injury could provide potential strategies for clinically improving the prognosis of stroke. Ring finger protein 13 (RNF13) has been proven to be involved in the inflammatory response.

A Hybrid Perovskite-Based Electromagnetic Wave Absorber with Enhanced Conduction Loss and Interfacial Polarization through Carbon Sphere Embedding.

Electronic equipment brings great convenience to daily life but also causes a lot of electromagnetic radiation pollution. Therefore, there is an urgent demand for electromagnetic wave-absorbing materials with a low thickness, wide bandwidth, and strong absorption. This work obtained a high-performance electromagnetic wave absorption system by adding conductive carbon spheres (CSs) to the CHNHPbI (MAPbI) absorber.

Genetic and clinical characteristics of ZNF408-related familial exudative vitreoretinopathy.

Objective: To analyze the clinical and genetic characteristics of zinc finger protein 408 ()-related familial exudative vitreoretinopathy (FEVR) in a Chinese cohort.

Methods: Ninety families from Chongqing and 16 families from Xinjiang were selected according to fundus lesion characteristics. Peripheral venous blood was collected from patients and their families; genomic DNA was extracted for whole exome sequencing.

A Highly Efficient Electromagnetic Wave Absorption System with Graphene Embedded in Hybrid Perovskite.

To cope with the explosive increase in electromagnetic radiation intensity caused by the widespread use of electronic information equipment, high-performance electromagnetic wave (EMW)-absorbing materials that can adapt to various frequency bands of EMW are also facing great demand. In this paper, CHNHPbI/graphene (MG) high-performance EMW-absorbing materials were innovatively synthesized by taking organic-inorganic hybrid perovskite (OIHP) with high equilibrium holes, electron mobility, and accessible synthesis as the main body, graphene as the intergranular component, and adjusting the component ratio. When the component ratio was 16:1, the thickness of the absorber was 1.

NiMnO Anchored on Reduced Graphene Oxide Nanosheets: A New High-Performance Microwave Absorbing Material.

With the increasing influence of electromagnetic radiation on precision instruments and organisms, there is an urgent need for research on lightweight and high-strength electromagnetic wave absorbing materials. This study has probed into a new composite absorbing material based on reduced graphene oxide (rGO)-NiMnO, where the like-core-shell NiMnO is anchored on the rGO nanosheets to significantly improve the electromagnetic wave dissipation ability of the composite material using the inter-component dipole polarization and interface polarization. At the same time, NiMnO can effectively adjust the impedance matching ratio of rGO so that electromagnetic waves can effectively enter the absorbing material.

A flexible electrostatic nanogenerator and self-powered capacitive sensor based on electrospun polystyrene mats and graphene oxide films.

Electrostatic nanogenerators or capacitive sensors that leverage electrostatic induction for power generation or sensing, has attracted significant interests due to their simple structure, ease of fabrication, and high device stability. However, in order for such devices to work, an additional power source or a post-charging process is necessary to activate the electrostatic effect. In this work, an electrostatic nanogenerator is fabricated using electrospun polystyrene (PS) mats and dip-coated graphene oxide (GO) films as the self-charged components.

Effects of ion migration and improvement strategies for the operational stability of perovskite solar cells.

The fundamental factor affecting the stability of perovskite solar cells, ion migration, has been reviewed, which is found to be closely related to the degradation of perovskite solar cells. Characterization methods like impedance spectroscopy and galvanostatic measurement to identify ion migration in perovskite films have been reviewed. The influence of light on ion migration was further discussed, which could largely explain the photo-stability decay in most perovskite solar cells.

Evaluation of the neuroprotective effect of EGCG: a potential mechanism of mitochondrial dysfunction and mitochondrial dynamics after subarachnoid hemorrhage.

(-)-Epigallocatechin-3-gallate (EGCG), the main bioactive component of tea catechins, exhibits broad-spectrum health efficacy against mitochondrial damage after subarachnoid hemorrhage (SAH). The mechanisms, however, are largely unknown. Here, the ability of EGCG to rescue mitochondrial dysfunction and mitochondrial dynamics following the inhibition of cell death was investigated by using in vitro and in vivo SAH models.

Proton Migration in Hybrid Lead Iodide Perovskites: From Classical Hopping to Deep Quantum Tunneling.

The organic-inorganic halide perovskites (OIHPs) have shown enormous potential for solar cells, while problems like the current-voltage hysteresis and the long-term instability have seriously hindered their applications. Ion migrations are believed to be relevant. But the atomistic details still remain unclear.

p38 Inhibitor Protects Mitochondrial Dysfunction by Induction of DJ-1 Mitochondrial Translocation After Subarachnoid Hemorrhage.

p38 mitogen-activated protein kinase (MAPK) is a major player in mitochondrial dysfunction after subarachnoid hemorrhage (SAH). Moreover, DJ-1, which responds to oxidative stress and translocates to mitochondria, maintains mitochondrial homeostasis. Although a few studies have demonstrated that DJ-1 indirectly regulates p38 activation, the relationship between DJ-1 and p38 in mitochondrial dysfunction after SAH has not been delineated.

In Situ Cesium Modification at Interface Enhances the Stability of Perovskite Solar Cells.

A consensus has been reached that organic transport layer (e.g., Spiro-OMeTAD) in perovskite solar cell (PSC) is prone to be impact by mobile ions in perovskite film during long-term operation.

Efficient Perovskite Solar Cells Fabricated Through CsCl-Enhanced PbI Precursor via Sequential Deposition.

The fabrication of high-quality perovskite film highly relies on chemical composition and the synthesis method of perovskite. So far, sequentially deposited MA FA Pb(I Br ) polycrystalline film is adopted to produce high-performance perovskite solar cells with record power conversion efficiency (PCE). Fewer grain boundaries and incorporation of inorganic cation (e.

A Two-Dimensional Hole-Transporting Material for High-Performance Perovskite Solar Cells with 20 % Average Efficiency.

A readily available small molecular hole-transporting material (HTM), OMe-TATPyr, was synthesized and tested in perovskite solar cells (PSCs). OMe-TATPyr is a two-dimensional π-conjugated molecule with a pyrene core and four phenyl-thiophene bridged triarylamine groups. It can be readily synthesized in gram scale with a low lab cost of around US$ 50 g .

MiR-129-5p inhibits glioma cell progression in vitro and in vivo by targeting TGIF2.

This study purposed to explore the correlation between miR-129-5p and TGIF2 and their impacts on glioma cell progression. Differentially expressed miRNA was screened through microarray analysis. MiR-129-5p expression levels in glioma tissues and cells were measured by qRT-PCR.

Associations between , and and Behçet's disease but not VKH syndrome in Han Chinese.

The present study was designed to explore the interrelationship between single nucleotide polymorphisms (SNP) of the tumor necrosis factor superfamily (TNFSF) and its respective receptor superfamily (TNFRSF) genes and Behcet's disease (BD) and Vogt-Koyanagi-Harada syndrome (VKH) in Han Chinese. The study sample included 796 patients with BD, 792 patients with VKH syndrome, and 1604 healthy controls. The genotyping of 35 SNPs was performed by MassARRAY platform (Sequenom), iPLEX Gold Assay, PCR-restriction fragment length polymorphism assay and TaqMan SNP assay.

Differential expression of microRNAs contributed to the health efficacy of EGCG in in vitro subarachnoid hemorrhage model.

(-)-Epigallocatechin-3-gallate (EGCG) exhibits a broader spectrum health efficacy in subarachnoid hemorrhage (SAH) therapy; the mechanisms, however, are largely unknown. Given that miRNAs play important roles in regulation of thousands of gene expressions, the effect of EGCG on the expression of miRNAs was investigated to explore the multi-targeting actions of EGCG by using an in vitro SAH model. MTT and western blot assays were used to assess the health effects of EGCG in SAH progression; the results showed that oxyhemoglobin (OxyHb)-induced cell proliferation and excessive autophagic activation were significantly inhibited by 50 μM EGCG, but not by 1 μM EGCG.

Light-Independent Ionic Transport in Inorganic Perovskite and Ultrastable Cs-Based Perovskite Solar Cells.

Due to light-induced effects in CHNH-based perovskites, such as ion migration, defects formation, and halide segregation, the degradation of CHNH-based perovskite solar cells under maximum power point is generally implicated. Here we demonstrated that the effect of light-enhanced ion migration in CHNHPbI can be eliminated by inorganic Cs substitution, leading to an ultrastable perovskite solar cell. Quantitatively, the ion migration barrier for CHNHPbI is 0.

Quantification of light-enhanced ionic transport in lead iodide perovskite thin films and its solar cell applications.

Ionic transport in organometal halide perovskites is of vital importance because it dominates anomalous phenomena in perovskite solar cells, from hysteresis to switchable photovoltaic effects. However, excited state ionic transport under illumination has remained elusive, although it is essential for understanding the unusual light-induced effects (light-induced self-poling, photo-induced halide segregation and slow photoconductivity response) in organometal halide perovskites for optoelectronic applications. Here, we quantitatively demonstrate light-enhanced ionic transport in CHNHPbI over a wide temperature range of 17-295 K, which reveals a reduction in ionic transport activation energy by approximately a factor of five (from 0.

Enhanced long-term stability of perovskite solar cells by 3-hydroxypyridine dipping.

Lead halide perovskite solar cells show poor stability due to their ionic material character. Here, we introduce a dipping method to modify the perovskite layer with 3-hydroxypyridine molecules. The long-term stability of solar cells is greatly enhanced and shows no obvious decay after 90 hour steady-state measurements.

Flexible perovskite solar cells based on the metal-insulator-semiconductor structure.

The metal-insulator-semiconductor (MIS) structure is applied to perovskite solar cells, in which the traditional compact layer TiO2 is replaced by Al2O3 as the hole blocking material to realize an all-low-temperature process. Flexible devices based on this structure are also realized with excellent flexibility, which hold 85% of their initial efficiency after bending 100 times.

[Expression and clinical significance of ING4 and HIF-1 alpha in brain astrocytoma].

Objective: To study the mRNA expression level of growth inhibition factor 4 (ING4) and hypoxia inducing factor 1 alpha (HIF-1 alpha), and their relationship with tumor malignant degree or the pathology classification in human brain astrocytoma.

Methods: The mRNA expression levels of ING4 and HIF-1 alpha were detected by RT-PCR method in 45 cases of grade I-IV human brain astrocytoma and 11 cases of control brain tissues from January 2009 to June 2010 in the Second Affiliated Hospital of Zhengzhou University, and their correlation was also analyzed.

Results: In the non-tumor brain tissue, the expression level of ING4 mRNA was 1.

Reduction in Autophagy by (-)-Epigallocatechin-3-Gallate (EGCG): a Potential Mechanism of Prevention of Mitochondrial Dysfunction After Subarachnoid Hemorrhage.

Mitochondrial dysfunction and subsequent autophagy, which are common features in central nervous system (CNS) disorders, were found to contribute to neuronal cell injury after subarachnoid hemorrhage (SAH). (-)-Epigallocatechin-3-gallate (EGCG), the main biological active of tea catechin, is well known for its beneficial effects in the treatment of CNS diseases. Here, the ability of EGCG to rescue cellular injury and mitochondrial function following the improvement of autophagic flux after SAH was investigated.

A polymer scaffold for self-healing perovskite solar cells.

Advancing of the lead halide perovskite solar cells towards photovoltaic market demands large-scale devices of high-power conversion efficiency, high reproducibility and stability via low-cost fabrication technology, and in particular resistance to humid environment for long-time operation. Here we achieve uniform perovskite film based on a novel polymer-scaffold architecture via a mild-temperature process. These solar cells exhibit efficiency of up to ∼ 16% with small variation.

Inhibitory effect of DNA topoisomerase inhibitor isoliquiritigenin on the growth of glioma cells.

Objective: To investigate the effect of isoliquiritigenin on the activity of DNA topoisomerase (TOP I) and its inhibitory effect on the growth of U87 glioma cells.

Methods: This study investigated the inhibitory effect of isoliquiritigenin on the growth of U87 glioma cells and its cytotoxicity by MTT method and determined the effect of isoliquiritigenin on TOP I activity by agarose gel electrophoresis. On this basis, we studied the interaction between isoliquiritigenin and TOP I and DNA.

GSK1838705A, an IGF-1R inhibitor, inhibits glioma cell proliferation and suppresses tumor growth in vivo.

Glioma is a type of primary malignant tumor of the central nervous system in humans. At present, standard treatment involves surgical resection, followed by radiation therapy and chemotherapy. However, the prognosis is poor and the long‑term survival rate remains low.