Publications by authors named "Wenkang Liu"

Purpose: Neoadjuvant immunochemotherapy is emerging as a promising regimen for patients with locally advanced gastric and gastroesophageal junction (G/GEJ) adenocarcinoma. However, it remains unclear whether immunochemotherapy will bring more adverse events (AEs) leading to a delay or even cancellation of surgeries. We aimed to provide a comprehensive analysis of the toxicity profiles for immune checkpoint inhibitors (ICIs) combined with chemotherapy among patients with G/GEJ adenocarcinoma.

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Neoadjuvant immunochemotherapy (NAIC) achieves superior clinical benefits over neoadjuvant chemotherapy (NAC) in multiple types of human cancers, including gastric adenocarcinoma (GAC). However, it is poorly understood how the malignant epithelial cells and tumor immune microenvironment (TIME) might respond distinctly to NAIC and NAC that underlies therapeutic efficacy. Here treatment-naive and paired tumor tissues from multiple centers were subjected to pathological, immunological, and transcriptomic analysis.

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Malaria is a potentially fatal infective illness caused due to parasites that belong to the Plasmodium genus, which are transferred to humans with the help of the stings of affected female Anopheles mosquitoes, and it persists as a serious public wellness problem worldwide. Cordia myxa is a medicinal plant that possesses various medicinal characteristics like antimicrobial, anti-inflammation, antioxidant, and antidiabetic activities, which makes it an important natural resource for the therapy of different maladies in traditional medicine. In this investigation, a certain network pharmacology method has been utilized to identify the potent active components, possible targets as well as signaling pathways present in C.

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Ethnopharmacological Relevance: Peganum harmala L., a traditional Uyghur ethnic medicine widely used in China, is commonly used in the treatment of conditions such as hemiplegia, forgetfulness, cough, and asthma. Harmine and other β-carboline alkaloids, one of the main active ingredients in P.

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Cis-trans isomers of N-isobutyl-2E,4E,8Z,10E-dodecatetraenamide (DDA-E) and N-isobutyl-2E,4E,8Z,10Z-dodecatetraenamide (DDA-Z) are representative alkamides with numbness of tongue, anti-inflammatory and analgesic activities of Asari Radix et Rhizoma. However, their respective metabolic pathways and pharmacokinetic behaviors are still unknown. This study aim to investigate the metabolism of the two alkamides in vitro and in vivo using ultra-high-performance liquid chromatography-quadruple-time-of-flight mass spectrometry.

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Purpose: To assess the clinical efficacy of arthroscopic treatment for posterior cruciate ligament (PCL) tibial avulsion fractures using high-intensity suture binding combined with button plate suspension fixation.

Methods: We retrospectively analyzed clinical data from 32 patients with PCL tibial avulsion fractures treated at our hospital from July 2020 to August 2023. We recorded operation time, intraoperative and postoperative complications, and used imaging to assess fracture reduction and healing.

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Article Synopsis
  • Researchers have developed a new nanozyme called MGBC that mimics neutrophils to fight MRSA infections by delivering chloroperoxidase (CPO) more effectively and self-supplying hydrogen peroxide (HO).
  • MGBC catalyzes glucose to generate HO, enabling a prolonged production of reactive oxygen species (O) through CPO, and also releases nitric oxide (NO) for enhanced gas therapy.
  • This combined approach not only effectively kills MRSA and erases biofilms, but also reduces drug resistance by downregulating key genes related to virulence and biofilm formation.
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Article Synopsis
  • Zuojin Pill (ZJP) is a traditional Chinese medicine primarily used for gastric disorders, composed of Rhizoma Coptidis and Euodiae Fructus in a 6:1 ratio.
  • The study developed a method using UHPLC-Q-TOF-MS to analyze the in vivo metabolism and distribution of protoberberine alkaloids (PBAs) and indole alkaloids (IDAs) in rats, identifying 33 compounds, including 7 primary alkaloids and 26 metabolites.
  • The findings revealed that these alkaloids and metabolites preferentially localized in the stomach and interacted strongly with key targets associated with gastritis, providing insights for future research into ZJP's therapeutic mechanisms.
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Objective: To compare the clinical efficacy of artificial total hip arthroplasty(THA) for femoral neck fracture between direct anterior approach(DAA) in lateral position and posterior lateral approach(PLA).

Methods: Comparison of 200 cases of patients who underwent THA collected between September 2019 and August 2021 was done. Incision length, intraoperative bleeding, operative time, difference in postoperative haemoglobin from preoperative levels, length of hospital stay, postoperative time to get off the floor, visual analogue score (VAS) for pain, preoperative and postoperative Harris scores for the hip, and measurements of the acetabular abduction angle and anterior acetabular tilt angle at 6 months postoperatively were collected, and all the cases were followed up for at least 2 years.

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Slow healing at the tendon-bone interface is a prominent factor in the failure of tendon repair surgeries. The development of functional biomaterials with 3D gradient structures is urgently needed to improve tendon-bone integration. The crystalline form of hydroxyapatite (HAP) has a crucial impact on cell behavior, which directly influences protein adsorption, such as bone morphogenetic protein 2, the adhesion, proliferation, and osteogenic differentiation with cells.

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Parametric splines are popular tools for precision optical metrology of complex freeform surfaces. However, as a promising topologically unconstrained solution, existing T-spline fitting techniques, such as improved global fitting, local fitting, and split-connect algorithms, still suffer the problems of low computational efficiency, especially in the case of large data scales and high accuracy requirements. This paper proposes a speed-improved algorithm for fast, large-scale freeform point cloud fitting by stitching locally fitted T-splines through three steps of localized operations.

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Background: Since arthroscopy was discovered to treat acromioclavicular joint injury, people have had great interest and attention to this beautiful and minimally invasive operation, and related research has been increasing worldwide. At present, there is no bibliometric and visualized analysis in this field. The purpose of this study is to explore the research hotspots and trends of arthroscopic treatment of acromioclavicular joint injury through bibliometric and visualized analysis and look forward to the future development direction of clinical practice.

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Mo, TiH, Al and graphite elemental powders were used as starting materials for the activation reaction sintering process, which was employed to fabricate porous MoTiAlC. The alteration of phase constitution, volume expansion, porosity, pore size and surface morphology of porous MoTiAlC with sintering temperatures ranging from 700 °C to 1500 °C were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and pore size tester. Both the pore formation mechanism and activation reaction process at each temperature stage were investigated.

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Ce-MnO composite oxide catalysts with different proportions were prepared using the coprecipitation method, and the CO-removal ability of the catalysts with the tested temperature range of 60-140 °C was investigated systematically. The effect of Ce and Mn ratios on the catalytic oxidation performance of CO was investigated using X-ray diffraction (XRD), X-ray energy dispersive spectroscopy (EDS), scanning electron microscopy (SEM), H temperature programmed reduction (H-TPR), CO-temperature programmed desorption (CO-TPD), and in situ infrared spectra. The experimental results reveal that under the same test conditions, the CO conversion rate of pure MnO reaches 95.

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Currently, multidrug resistant (MDR) bacterial infections are a great threat to public health, and the development of novel strategies for high efficiency combatting of MDR bacteria is in urgent demand. Hydrogen (H) is a small gas with a high reducing ability, and plenty of recent studies have demonstrated its therapeutic effect on many diseases. However, the antibacterial effectiveness and mechanism of H against MDR bacteria are still unknown.

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Background: Sodium formononetin-3'-sulphonate (Sul-F) may alleviate I/R injury in vivo with uncertain mechanism. Endoplasmic reticulum (ER) stress-mediated apoptosis participates in the process of cerebral ischemia-reperfusion (I/R) injury. Our aim is to figure out the effect of Sul-F on cerebral I/R injury and to verify whether it works through suppressing ER stress-mediated apoptosis.

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Exploring highly efficient and durable catalysts for the hydrogen evolution reaction (HER) is crucial for the hydrogen economy and environmental protection issues. Numerous studies have now found that transition metal carbide MXenes are ideal candidates as catalysts for the hydrogen evolution reaction. However, MXenes are inclined to easily undergo lamellar structure agglomeration and stacking, which impedes their further applications.

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Recently, nitric oxide (NO) has received increasing interest in combat against bacteria-induced infections because of its ability to sensitize and enhance the antibacterial effectiveness of many therapeutic approaches such as antibiotics. However, high-efficient loading and controlled release of NO remain a big challenge. In the present work, a type of gold nanostar/hollow polydopamine Janus nanostructure (GNS/HPDA JNPs) with precise near infrared (NIR)-controlled NO release property was fabricated using a facile seed-mediated method.

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The study on the quantification of ecological compensation (eco-compensation) in a river basin can help to make environmental protection more compatible with ecological construction. In this paper, the upstream and downstream of the river basin were treated as the subjects and objects of eco-compensation, and the mechanism of eco-compensation was clarified. The emergy analysis theory (EMA) was used to calculate the values of water resources in sub-industries (agriculture, industry, life, and recreation).

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Due to the complexity of ecological compensation standards and methods, some problems cannot be expected before compensation, but the evaluation of eco-compensation effect can feedback the implementation effect of eco-compensation policies and provide reference for the improvement of eco-compensation policies. This paper constructed a comprehensive evaluation index system of eco-compensation, which covered social and economic development, pollution discharge and monitoring, and pollution treatment aspects. An eco-compensation comprehensive evaluation model was established, which consisted of the projection pursuit model (PP model) and the chaotic particle swarm optimization algorithm (CPSO algorithm).

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Background: Apoptosis-stimulating protein of p53 (ASPP) family members can stimulate the apoptotic function of p53 but have no impact on its cell cycle arrest function.

Material And Methods: The expression pattern of the ASPP family consisting of ASPP1, ASPP2, and iASPP was examined by immunohistochemistry in 45 formalin-fixed and paraffin-embedded endometrial endometrioid adenocarcinoma (EEA) specimens and 26 normal endometrial tissue (NET) samples.

Results: The expression rates of ASPP1 and ASPP2 in EEA were significantly lower than those in NET (p < 0.

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Background: Endometrial cancer is the 4th most common gynecological cancer. The expression of prostate stem cell antigen (PSCA), piwi-like 1 (PIWIL1), and T-box 2 (TBX2) in endometrial cancer remains to be elucidated.

Material And Methods: The expression of PSCA, PIWIL1, and TBX2 was examined using the streptavidin-peroxidase method in 64 endometrial endometrioid adenocarcinoma (EAC) and paired normal endometrium (NE) samples from the Shaanxi Province in China.

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The purpose of our study was to investigate the expression of prostate stem cell antigen (PSCA), piwi-like 1 (PIWIL1) and T-box 2 (TBX2) and its correlation with HPV16 infection in cervical squamous cell carcinoma (CSCC). HPV16 was detected by amplifying the HPV16 E7 gene by the polymerase chain reaction (PCR) method, and the expression of PSCA, PIWIL1, TBX2 and HPV16 E7 in 59 CSCCs and matched adjacent normal cervix (MANC) was examined by the streptavidin-peroxidase (SP) method. Fifty-two CSCCs and MANC specimens that were positive for the E7 gene and the E7 protein were identified as infected with HPV16 and included in present study.

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Background: Esophageal cancer is the fourth most prevalent malignancy in China. The relationship between COX-2, CD44v6, and nm23H1 in esophageal squamous cell carcinoma (ESCC) remains unclear.

Material And Methods: Expression of COX-2, CD44v6, and nm23H1 was examined, using the streptavidin-peroxidase method, in 82 ESCC and 30 normal esophageal mucosa (NEM) samples from the Shaanxi Province in China.

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Article Synopsis
  • - The study aimed to explore the link between HPV16 infection and the proteins COX-2 and P53 in esophageal squamous cell carcinoma (ESCC), which was not previously understood.
  • - The research showed that HPV16 and COX-2 were significantly more prevalent in ESCC samples compared to normal esophageal tissue, with correlations between COX-2 expression levels and tumor characteristics like stage and metastasis.
  • - HPV16 infection negatively correlated with COX-2 overexpression but showed no significant relationship with P53 levels; however, higher COX-2 levels were positively linked to P53 expression in ESCC.
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