Alterations of the bile microbiome is associated with progression-free survival in pancreatic ductal adenocarcinoma patients.

Background: Patients with pancreatic ductal adenocarcinoma (PDAC) display an altered oral, gastrointestinal, and intra-pancreatic microbiome compared to healthy individuals. However, knowledge regarding the bile microbiome and its potential impact on progression-free survival in PDACs remains limited.

Methods: Patients with PDAC (n = 45), including 20 matched pairs before and after surgery, and benign controls (n = 16) were included prospectively.

Activation of the osteoblastic HIF-1α pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegIIIγ.

The hypoxia-inducible factor-1α (HIF-1α) pathway coordinates skeletal bone homeostasis and endocrine functions. Activation of the HIF-1α pathway increases glucose uptake by osteoblasts, which reduces blood glucose levels. However, it is unclear whether activating the HIF-1α pathway in osteoblasts can help normalize glucose metabolism under diabetic conditions through its endocrine function.

Time-course swRNA-seq uncovers a hierarchical gene regulatory network in controlling the response-repair-remodeling after wounding.

Wounding initiates intricate responses crucial for tissue repair and regeneration. Yet, the gene regulatory networks governing wound healing remain poorly understood. Here, employing single-worm RNA sequencing (swRNA-seq) across 12 time-points, we delineated a three-stage wound repair process in C.

Algae polysaccharide-induced transport transformation of nanoplastics in seawater-saturated porous media.

This study examined the distinct effects of algae polysaccharides (AP), namely sodium alginate (SA), fucoidan (FU), and laminarin (LA), on the aggregation of nanoplastics (NP) in seawater, as well as their subsequent transport in seawater-saturated sea sand. The pristine 50 nm NP tended to form large aggregates, with an average size of approximately 934.5 ± 11 nm.

Separation of Mono-/Divalent Ions via Controlled Dynamic Adsorption/Desorption at Polythiophene Coated Carbon Surface with Flow-Electrode Capacitive Deionization.

Capacitive deionization for selective separation of ions is rarely reported since it relies on the electrostatic attraction of oppositely charged ions with no capability to distinguish ions of different valent states. Using molecular dynamic simulation, a screening process identified a hybrid material known as AC/PTh, which consists of activated carbon with a thin layer of polythiophene (PTh) coating. By utilizing AC/PTh as electrode material implementing the short-circuit cycle (SCC) mode in flow-electrode capacitive deionization (FCDI), selective separation of mono-/divalent ions can be realized via precise control of dynamic adsorption and desorption of mono-/divalent ions at a particular surface.

Black Phosphorus Accelerates Bone Regeneration Based on Immunoregulation.

A fundamental understanding of inflammation and tissue healing suggests that the precise regulation of the inflammatory phase, both in terms of location and timing, is crucial for bone regeneration. However, achieving the activation of early inflammation without causing chronic inflammation while facilitating quick inflammation regression to promote bone regeneration continues to pose challenges. This study reveals that black phosphorus (BP) accelerates bone regeneration by building an osteogenic immunological microenvironment.

Satellite record reveals 1960s acceleration of Totten Ice Shelf in East Antarctica.

Wilkes Land and Totten Glacier (TG) in East Antarctica (EA) have been losing ice mass significantly since 1989. There is a lack of knowledge of long-term mass balance in the region which hinders the estimation of its contribution to global sea level rise. Here we show that this acceleration trend in TG has occurred since the 1960s.

Urchin-like ceria nanoparticles for enhanced gene therapy of osteoarthritis.

Osteoarthritis (OA) is the most common degenerative joint disease in the world. Gene therapy based on delivering microRNAs (miRNAs) into cells has potential for the treatment of OA. However, the effects of miRNAs are limited by the poor cellular uptake and stability.

Performance evaluation of the UV activated chlorite process on trimethoprim: Degradation efficiency, energy consumption and disinfection by-products formation.

As the primary inorganic by-product species of ClO, chlorite is believed to have negative toxicological effects on human health and therefrom greatly limits the wide application of ClO in water treatment. The synergistic trimethoprim (TMP) removal concerning degradation efficiency, energy consumption and disinfection by-products (DBPs) formation in the UV activated chlorite process accompanied by the simultaneously elimination of chlorite was comprehensively evaluated. UV/chlorite integrated process removed TMP far more rapidly than UV (1.

Regulating Surface Wettability and Charge Density of Porous Carbon Particles by In Situ Growth of Polyaniline for Constructing an Efficient Electrical Percolation Network in Flow-Electrode Capacitive Deionization.

Both electrical conductivity and surface wettability are required for the selection of active carbon materials in flow-electrode capacitive deionization, while a trade-off exists between these two properties. In this work, a hybrid material with a thin layer of polyaniline (PANI) coating on activated carbon (AC/PANI) was successfully developed to retain excellent electrical conductivity and acquire good surface wettability. By adjusting the dosage of initiator, AC/PANI composites with different loading fractions of PANI were obtained.

Several carbon-coated GaO anodes: efficient coating of reduced graphene oxide enhanced the electrochemical performance of lithium ion batteries.

Gallium oxide as a novel electrode material has attracted attention because of its high stability and conductivity. In addition, Ga2O3 will be converted to Ga during the charge and discharge process, and the self-healing behavior of Ga can improve the cycling stability. In this paper, we synthesized Ga2O3 nanoparticles with a size of about 4 nm via a facile sol-gel method.

One-step synthesis of MOF-derived Ga/GaO@C dodecahedra as an anode material for high-performance lithium-ion batteries.

A Ga/GaO@C dodecahedron composite with a high specific capacity of about 542 mA h g after 200 cycles at the current density of 1000 mA g was synthesized by one-step hydrogen reduction. This hierarchical homogeneous structure combined the Ga, GaO and carbon frameworks (from Ga-MOF) to exhibit excellent electrochemical performance.

A novel Zr-MOF-based and polyaniline-coated UIO-67@Se@PANI composite cathode for lithium-selenium batteries.

In this work, we synthesized a novel UIO-67@Se@PANI composite cathode material for Li-Se battery applications. Zr-MOFs (metal organic frameworks) were used as a support and a PANI (polyaniline) layer was employed as the coating. UIO-67@Se@PANI was expected to be one of the candidates for Li-Se batteries, with a high specific capacity of 248.

BiS/C nanorods as efficient anode materials for lithium-ion batteries.

BiS is a promising negative electrode material for lithium storage owing to its high theoretical capacity. Nevertheless, the capacity of BiS decays very rapidly upon Li cycling. Here, BiS and BiS/C were successfully synthesized by a novel route.