Functional Hydrogel Interfaces for Cartilage and Bone Regeneration.

Effective treatment of bone diseases is quite tricky due to the unique nature of bone tissue and the complexity of the bone repair process. In combination with biological materials, cells and biological factors can provide a highly effective and safe treatment strategy for bone repair and regeneration, especially based on these multifunctional hydrogel interface materials. However, itis still a challenge to formulate hydrogel materials with fascinating properties (e.

Research on Flower Pattern and Roll Positioning Optimization for Roll Forming Process of TA4 Coiled Tubing.

Titanium alloy coiled tubing (CT) has great superiority while operating in deep wells with severe conditions, but it faces serious challenges during roll forming like high springback, edge cracking and surface wearing. In order to utilize the high precision and high efficiency production of titanium alloy CT, it is urgently necessary to develop a detailed process design. Based on the W-forming strategy and the cubic curve of the strip edge projection, the flower pattern and roll design for the 21-pass roll forming process were completed.

Diameter thresholds for pure ground-glass pulmonary nodules at low-dose CT screening: Chinese experience.

Background: Limited research exists on screening thresholds for low-dose CT in detecting malignant pure ground-glass lung nodules (pGGNs) in the Chinese population.

Materials And Methods: A retrospective analysis of the Guangzhou Lung-Care programme was conducted, retrieving average transverse diameter, location, histopathology, frequency and follow-up intervals. Diagnostic performances for 'lung cancers' were evaluated using areas under the curve (AUCs), decision curve analysis (DCA), sensitivities and specificities, with thresholds ranging from 5 mm to 10 mm.

Association of pre-existing conditions with major driver mutations and PD-L1 expression in NSCLC.

Objectives: This study aims to explore how pre-existing conditions such as blood types, family history of cancer and comorbid diseases correlate with the genetic and programmed death-ligand 1 (PD-L1) expression that contributes to the heterogeneous biological behaviours of non-small cell lung cancer (NSCLC).

Materials And Methods: A cohort of 5507 NSCLC patients who underwent surgical resection between January 2014 and July 2018 was studied. Targeted next-generation sequencing was used to detect mutations in nine pivotal cancer-related genes, and immunohistochemical staining was applied to assess PD-L1 expression.

Data-Driven Design of Nickel-Free Superelastic Titanium Alloys.

In this paper, a CatBoost model for predicting superelastic strains of alloys was established by utilizing features construction and selection as well as model filtering and evaluation based on 125 existing data points of superelastic titanium alloys. The alloy compositions of a TiNbMoZrSnTa system were optimized and three nickel-free titanium alloys with potentially excellent superelastic properties were designed using the Bayesian optimization algorithm using a superelastic strain as the optimization target. The experimental results indicated that only Ti-12Nb-18Zr-2Sn and Ti-12Nb-16Zr-3Sn exhibited clear superelasticity due to the absence of relevant information about the alloys' β stability in the machine learning model.

Versatile Composite Binder with Fast Lithium-Ion Transport for LiCoO Cathodes.

The low ionic conductivity of LiCoO limits the rate performance of the overall electrode. Here, a polymeric composite binder composed of poly(vinylidene fluoride) (PVDF) and poly(ethylene oxide) (PEO) is reported to efficiently improve the ion transport in the LiCoO electrode. This is where the lithium-ion transport channel constructed by oxygen atoms of PEO can afford the electrode a lithium-ion transport number () as high as 0.

Iodine-Mediated δ-Amination of sp C-H Bonds.

We present a direct δ-amination reaction of sp C-H bonds, employing molecular iodine (I) as the sole oxidant under transition-metal-free conditions. This remote C-H functionalization approach is operationally simple and provides facile, efficient access to pyrrolidines and related heterocyclic derivatives from readily accessible substrates.

Effect of Cold Deformation and Heat Treatment on the Microstructures and Mechanical Properties of Au-15Ag-12Cu-6Ni Alloy Sheets.

The evolution of the microstructure and hardness changes in the Au-15Ag-12Cu-6Ni alloy during the processes of cold rolling and annealing were investigated and the heat treatment regimen for the alloy was optimized in this article. The hardness of the alloy continuously increases with the cold rolling reductions, leading to continuous deformation of the grains during the cold rolling process, ultimately resulting in smaller grain sizes. Subsequent annealing induces recovery and recrystallization, achieving complete recrystallization at 700 °C.

Equivalent Heat Treatments and Mechanical Properties in Cold-Rolled TiNiFe Shape-Memory Alloys.

Heat treatments after cold rolling for TiNiFe shape-memory alloys have been compared. After EBSD analysis and as calculated by the Avrami model and Arrhenius equation, the relationship between the heat-treatment temperature and manufacturing time of TiNiFe alloys is established. Through calculation, it can be found that TiNiFe alloys can obtain similar microstructures under the annealing processes of 823 K for 776 min, 827 K for 37 min, and 923 K for 12.

Iodine-Mediated α-C-H Amination of Carbonyl Compounds via Nitrogen-Directed Oxidative Umpolung.

A new synthetic strategy for direct C()-H amination of carbonyl compounds at their α-carbon has been established employing molecular iodine and nitrogen-directed oxidative umpolung. In this transformation, iodine acts not only as an iodinating reagent but also as a Lewis acid catalyst, and both the nitrogen-containing moiety and the carbonyl group in the substrate play important roles. This synthetic approach is applicable to a broad variety of carbonyl substrates, including esters, ketones, and amides.

Prepared Three-Dimensional Covalent and Hydrogen Bond Synergistic Binder to Boost the Performance of SiO Anodes for Lithium-Ion Batteries.

Polymer binders play an important role in enhancing the electrochemical performance of silicon-based anodes to alleviate the volume expansion for lithium-ion batteries. It is difficult for common one-dimensional (1D) linear binders to limit the volume expansion of a silicon-based electrode when combined with silicon-based particles with scant binding points. Therefore, it is necessary to design a three-dimensional (3D) network structure, which has multiple binding points with the silicon particles to dissipate the mechanical stress in the continuous charge and discharge circulation.

Synthesis of Quinazolinone-Fused Tetrahydroisoquinolines and Related Polycyclic Scaffolds by Iodine-Mediated sp C-H Amination.

An iodine-mediated intramolecular sp C-H amination reaction producing quinazolinone-fused polycyclic skeletons from 2-aminobenzamide precursors is reported. This reaction does not use transition metals, has a broad substrate scope, and can be used on a gram scale. Under the optimal reaction conditions, a variety of quinazolinone-fused tetrahydroisoquinolines and derivatives of Rutaecarpine were synthesized from readily accessible compounds.

Numerical Simulation and Process Optimization on Hot Twist-Stretch Straightening of Ti-6Al-4V Alloy Profile.

Ti-6Al-4V profiles prepared by hot extrusion are usually accompanied by bending and twisting. The hot twist-stretch straightening is an effective strategy such that the bending deflection and twisting angle can be simultaneously decreased by a single straightening process. In addition, utilizing stress relaxation effect, the residual stress and springback can be greatly reduced by holding the straightening temperature and strain constant for a period after twist-stretch straightening.

Modeling Based on a Two-Step Parameter Identification Strategy for Liquid Crystal Elastomer Actuator Considering Dynamic Phase Transition Process.

Liquid crystal elastomer (LCE) is a promising candidate for actuation in light-driven soft robot applications. Due to the fact that LCE has complex hysteretic nonlinearities, which are highly dependent on the environment, modeling of actuators made of LCE is a very challenging issue. In this article, a model is proposed to describe the deformation of the LCE actuator accurately and analytically by considering the dynamic phase transition process of LCE molecules.

Design, synthesis and biological evaluation of novel triazoloquinazolinone and imidazoquinazolinone derivatives as allosteric inhibitors of SHP2 phosphatase.

ABSTRCTA series of novel triazoloquinolinone and imidazoquinazolinone derivatives were designed and synthesised, and their biological activities against SHP2 protein and melanoma A357 cell line were evaluated in vitro. The results show that some target compounds have moderate to excellent inhibitory activity on SHP2 protein and melanoma A357 cell line. Structure-activity relationships (SARs) showed that both imidazoquinazolinone and triazoloquinazolinone derivatives have good SHP2 protein kinase and melanoma cell line A357 inhibitory activity.

Microstructure and Texture Evolution during Superplastic Deformation of SP700 Titanium Alloy.

The superplastic tensile test was carried out on SP700 (Ti-4.5Al-3V-2Mo-2Fe) titanium alloy sheet at 760 °C by the method of maximum m value, and the microstructure characteristics were investigated to understand the deformation mechanism. The results indicated that the examined alloy showed an extremely fine grain size of ~1.

Effect of 'Q' Ratio on Texture Evolution of Ti-3Al-2.5V Alloy Tube during Rolling.

Ti-3Al-2.5V alloy was usually the α phase of HCP structure at room temperature which had obvious anisotropy. During tube rolling, α grain would be influenced by stress-strain state, deformation amount, 'Q' ratio to result the preferred orientation and formed texture.

: Amelioration Effect on Imiquimod-Induced Psoriasis in Mice Based on a Tissue Metabonomic Analysis.

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Dynamic modeling of dielectric elastomer actuator with conical shape.

With desirable physical performances of impressive actuation strain, high energy density, high degree of electromechanical coupling and high mechanical compliance, dielectric elastomer actuators (DEAs) are widely employed to actuate the soft robots. However, there are many challenges to establish the dynamic models for DEAs, such as their inherent nonlinearity, complex electromechanical coupling, and time-dependent viscoelastic behavior. Moreover, most previous studies concentrated on the planar DEAs, but the studies on DEAs with some other functional shapes are insufficient.

In-Situ SEM Observation on Fracture Behavior of Titanium Alloys with Different Slow-Diffusing β Stabilizing Elements.

The fracture-behaviors of two Ti-Al-Sn-Zr-Mo-Nb-W-Si alloys with different slow-diffusing β stabilizing elements (Mo, W) were investigated through in-situ tensile testing at 650 °C via scanning electron microscopy. These alloys have two phases: the α phase with hcp-structure (a = 0.295 nm, c = 0.

A General Position Control Method for Planar Underactuated Manipulators With Second-Order Nonholonomic Constraints.

The study on the stabilization of planar underactuated manipulators without gravity is well recognized as a major challenge since the system includes a second-order nonholonomic constraint when the passive link is not located at the first link. It is important to solve this difficulty for applications such as systems working in aerospace or underwater. This article presents a position control method based on bidirectional motion planning and intelligent optimization for this kind of system.

Self-repaired Process of a Traumatized Maxillary Central Incisor with Pulp Infarct after Horizontal Root Fracture Monitored by Laser Doppler Flowmetry Combined with Tissue Oxygen Monitor.

Achieving a precise diagnosis of the pulp status of traumatized teeth is difficult. The time to interfere through endodontic treatment for these teeth is greatly dependent on the doctor's experience. A 24-year-old male patient suffered a traumatic injury to tooth #9 that resulted in an apical root horizontal fracture 3 days before he came to the hospital.

Conformational selection or induced fit for Brinker and DNA recognition.

Brinker is the key target protein of the Drosophila Decapentaplegic morphogen signalling pathway. Brinker is widely expressed and can bind with DNA. NMR spectra suggest that apo-Brinker is intrinsically unstructured and undergoes a folding transition upon DNA-binding.