Clinical characteristics associated with peripartum maternal bloodstream infection.

Objective: Bloodstream infection (BSI) during the peripartum period is a major cause of maternal morbidity and mortality. However, data on maternal BSI during hospitalization for delivery are limited. This study aimed to investigate the incidence, clinical characteristics, risk factors, microbiological features, and antibiotic resistance patterns of maternal peripartum BSI, with a focus on understanding the role of premature rupture of membranes (PROM), fever, and other risk factors in its development.

Regulated Cu Diatomic Distance Promoting Carbon-Carbon Coupling During CO Electroreduction.

To address the bottle-neck carbon-carbon coupling issue during electrochemical carbon dioxide reduction (eCORR) to multicarbon (C) products, this work develops an anion-directed strategy (Cl, NO , and SO ) to regulate interatomic distance of Cu diatoms. In comparison to pristine Cu (with a typical Cu-Cu distance of 2.53 Å), Cu-boroimidazole frameworks (BIF)/SO, NO, and Cl material shows elongated diatomic distance of 3.

Tet2 modulates M2 macrophage polarization via mRNA 5-methylcytosine in allergic rhinitis.

Background: Allergic rhinitis (AR) represents a hallmark of obvious hypersensitivity with an imbalance of immune responses, including abnormal macrophage activity in local tissues. It has been reported that alternatively activated macrophages (M2) may contribute to allergic pathogenesis. Ten-eleven translocation (Tet) enzymes can oxidize 5-methylcytosine (m5C) in mRNA, implying the epigenetic regulation of post-transcriptional RNA modification.

Verapamil attenuates myocardial ischemia/reperfusion injury by inhibiting apoptosis via activating the JAK2/STAT3 signaling pathway.

Apoptosis is a crucial pathological process in myocardial ischemia/reperfusion injury (MIRI). Verapamil (Ver), normally used to treat hypertension or heart rhythm disorders, also attenuates MIRI. The potential of Ver to inhibit apoptosis and thereby attenuate MIRI remains unclear, as does the mechanism.

Insight into the Rate-Determining Step in Photocatalytic Z-Scheme Overall Water Splitting by Employing A Series of Perovskite RTaON (R = Pr, Nd, Sm, and Gd) as Model Photocatalysts.

Photocatalysis is an intricate process that involves a multitude of physical and chemical factors operating across diverse temporal and spatial scales. Identifying the dominant factors that influence photocatalyst performance is one of the central challenges in the field. Here, we synthesized a series of perovskite RTaON semiconductors with different A-site rare earth atoms (R = Pr, Nd, Sm, and Gd) as model photocatalysts to discuss the influence of the A-site modulation on their local structures as well as both physical and chemical properties and to get insight into the rate-determining step in photocatalytic Z-scheme overall water splitting (OWS).

Kidney Injury Evoked by Fine Particulate Matter: Risk Factor, Causation, Mechanism and Intervention Study.

Fine particulate matter (PM) is suggested to pose a severe risk to the kidneys by inducing functional degradation and chronic kidney diseases (CKD). This study aims to explore the nephrotoxicity of PM exposure and the underlying mechanism. Herein, based on the UK Biobank, it is found that per interquartile range (IQR) increase in PM is associated with a 6% (95% CI: 1%-11%), 7% (95% CI: 3%-11%), 9% (95% CI: 4%-13%), 11% (95% CI: 9%-13%), and 10% (95% CI: 8%-12%) increase in the risk of nephritis, hydronephrosis, kidney stone, acute renal failure, and CKD, respectively.

Polyoxometalate-incorporated NiFe-based oxyhydroxides for enhanced oxygen evolution reaction in alkaline media.

NiFe-based oxyhydroxides are promising electrocatalysts for the oxygen evolution reaction (OER) in alkaline media, but further enhancing their OER performance remains a significant challenge. Herein, we incorporated polyoxometalates into NiFe oxyhydroxides to form a homogeneous/heterogeneous hybrid material, which induces the electronic interaction between Ni, Fe and Mo sites, as revealed by a variety of characterization experiments and theoretical calculations. The resulting hybrid electrocatalyst delivers a low overpotential of 203 mV at 10 mA cm and a TOF of 2.

A tellurium-based small compound ameliorates tumor metastasis by downregulating heparanase expression.

Tellurium is a rare element, and ammonium trichloro (dioxoethylene-o,o') tellurate (AS101) is the most bioactive molecule among several synthetic tellurium compounds. AS101 was found to be immunomodulatory and can modulate types of cytokines. However, the effect of AS101 on tumor metastasis remains unclear.

Main-Group Metal-Nonmetal Dynamic Proton Bridges Enhance Ammonia Electrosynthesis.

The electrochemical nitrogen reduction reaction (eNRR) is a crucial process for the sustainable production of ammonia (NH) for energy and agriculture applications. However, the reaction's efficiency is highly dependent on the activation of the inert N≡N bond, which is hindered by the electron back-donation to the π* orbitals of the N≡N bond, resulting in low eNRR capacity. Herein, we report a main-group metal-nonmetal (O-In-S) eNRR catalyst featuring a dynamic proton bridge, with In-S serving as the polarization pair and O functioning as the dynamic electron pool.

Comparison of the Application Value of Transthoracic Echocardiography in Diagnosing Patent Foramen Ovale Under Different States of Stimulation: A Retrospective Study.

Objective: This study aims to evaluate the application value of contrast-enhanced transthoracic echocardiography (cTEE) in the diagnosis of patent foramen ovale (PFO) under different states of stimulation, with the goal of enhancing the accuracy and efficiency of PFO diagnosis.

Methods: This research consecutively enrolled patients suspected of having PFO from October 2022 to February 2024, presenting primary clinical symptoms such as unexplained syncope, headache, dizziness, and stroke. Patients underwent standard transthoracic echocardiography (TTE) and cTEE under three different states of stimulation (resting state, coughing, and Valsalva maneuver).

Effect of music therapy on anxiety and depression in breast cancer patients: systematic review and meta-analysis.

To systematically evaluate the intervention effect of music therapy on anxiety and depression in breast cancer patients. Randomised controlled trial (RCT) on music therapy for anxiety and depression in breast cancer patients was searched from 7 major databases, PubMed, Embase, the Cochrane Library, WOS, CNIC, Wanfang, and Wipro, spanning the period of library construction to 23 October 2023, and the literature screening of music therapy for anxiety or depression in breast cancer patients was carried out by 2 experimentalists, each of whom conducted a literature screening RCT independently of the other anxiety or depression in a RCT. Methodological quality was evaluated using the PEDro scale; GRADE profiler software for quality of evidence; and RevMan 5.

Large-Scale Synthesis of High-Loading Single Metallic Atom Catalysts by a Metal Coordination Route.

Single atom catalyst (SAC) is one of the most efficient and versatile catalysts with well-defined active sites. However, its facile and large-scale preparation, the prerequisite of industrial applications, has been very challenging. This dilemma originates from the Gibbs-Thomson effect, which renders it rather difficult to achieve high single atom loading (< 3 mol%).

US Population Eligibility and Estimated Impact of Tirzepatide Treatment on Obesity Prevalence and Cardiovascular Disease Events.

Purpose: Tirzepatide promotes weight loss and reduces risk factors for cardiovascular disease (CVD) in adults with overweight and obesity. We examined the number of US adults eligible for tirzepatide and its impact on obesity and CVD events.

Methods: We identified US adults aged ≥ 18 years from the cross-sectional US National Health and Nutrition Examination Survey (NHANES) 2015-2018 eligible for tirzepatide based on SURMOUNT-1 trial eligibility criteria.

PM-induced cellular senescence drives brown adipose tissue impairment in middle-aged mice.

Airborne fine particulate matter (PM) exposure is closely associated with metabolic disturbance, in which brown adipose tissue (BAT) is one of the main contributing organs. However, knowledge of the phenotype and mechanism of PM exposure-impaired BAT is quite limited. In the study, male C57BL/6 mice at three different life phases (young, adult, and middle-aged) were simultaneously exposed to concentrated ambient PM or filtered air for 8 weeks using a whole-body inhalational exposure system.

Early Pulmonary Fibrosis-like Changes in the Setting of Heat Exposure: DNA Damage and Cell Senescence.

It is well known that extreme heat events happen frequently due to climate change. However, studies examining the direct health impacts of increased temperature and heat waves are lacking. Previous reports revealed that heatstroke induced acute lung injury and pulmonary dysfunction.

Electrosynthesis of HO Promoted by π-π Interaction on a Metal-Free Carbon Catalyst.

The synthesis of hydrogen peroxide (HO) through electrocatalytic oxygen reduction reaction is an ideal alternative to the current energy-intensive anthraquinone process, but developing cost-effective and high-efficiency electrocatalysts is still challenging. Herein, a metal-free graphitic carbon nitride/carbon nanotube (g-CN/CNT) hybrid catalyst can enhance HO production via π-π interaction is reported, achieving almost unity (97%) HO production at 0.57 V with high selectivity of over 92% across the wide potential range from 0.