The effect of warfarin knowledge on anticoagulation control among patients with heart valve replacement.

Background Although novel oral anticoagulants have been applied into clinical practice, warfarin remains the only approved oral anticoagulant for heart valve replacement. Currently, an increasing number of Chinese clinical pharmacists provide patients with warfarin education. However, little research to date has been carried out to evaluate the relationship between warfarin knowledge level and anticoagulation control among patients with heart valve replacement.

Efficacy of Traditional Chinese Medicine Tonifying Kidney (Bushen) and Activating Blood (Huoxue) Prescription for Premature Ovarian Insufficiency: A Systematic Review and Meta-Analysis.

Objective: We carried out this systematic review and meta-analysis to evaluate the effectiveness of TKABP on POI.

Methods: The following eight databases were searched from the establishment to September 30, 2019, for randomized controlled trials (RCTs): PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), the Chinese BioMedical database (CBM), Chinese Scientific Journal Database (VIP), and the Wanfang database. The quality of evidence was estimated by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE).

Small organic molecules with tailored structures: initiators in the transition-metal-free C-H arylation of unactivated arenes.

Simple, small organic molecules containing nitrogen and oxygen atoms in their structures have been disclosed to catalyze transition-metal-free C-H arylation of unactivated arenes with aryl iodides in the presence of BuOK. In this article, an optimized catalytically active molecule, (2-(methylamino)phenyl)methanol, was designed. A broad range of aryl iodides could be converted into the corresponding arylated products at 100 °C over 24 h with good to excellent yields.

Wrinkling of two-dimensional materials: methods, properties and applications.

Recently, two-dimensional (2D) materials, including graphene, its derivatives, metal films, MXenes and transition metal dichalcogenides (TMDs), have been widely studied because of their tunable electronic structures and special electrical and optical properties. However, during the fabrication of these 2D materials with atomic thickness, formation of wrinkles or folds is unavoidable to enable their stable existence. Meaningfully, it is found that wrinkled structures simultaneously impose positive changes on the 2D materials.

The Dynamics of P Granule Liquid Droplets Are Regulated by the Germline RNA Helicase GLH-1 via Its ATP Hydrolysis Cycle.

P granules are phase-separated liquid droplets that play important roles in the maintenance of germ cell fate in Both the localization and formation of P granules are highly dynamic, but mechanisms that regulate such processes remain poorly understood. Here, we show evidence that the VASA-like germline RNA helicase GLH-1 couples distinct steps of its ATPase hydrolysis cycle to control the formation and disassembly of P granules. In addition, we found that the phenylalanine-glycine-glycine repeats in GLH-1 promote its localization at the perinucleus.

Isolation of Trametes hirsuta La-7 with high laccase-productivity and its application in metabolism of 17β-estradiol.

Estrogens, which are extensive in the eco-environments, are a category of high-toxic emerging contaminants that induce metabolic disorders and even carcinogenic risks in wildlife and humans. Here we investigate whether fungus-secreted laccase can be used as a green catalyst to eliminate a representative estrogen, 17β-estradiol (E2). A white-rot fungus Trametes hirsuta La-7 with high laccase-productivity, was isolated from pig manure-contaminated soil.

Dysbiosis of oral microbiota is associated with systemic lupus erythematosus.

Objective: The important role of intestinal microbiota in systemic lupus erythematosus (SLE) has been recognized. Oral-gut microbiome axis is a crucial link in human health and disease, but few researches indicated the relationship between oral microorganisms and SLE. This study mainly explored the composition and changes of oral microorganisms in SLE patients with different stages, clinical manifestations and biomarkers.

Near full light absorption and full charge collection in 1-micron thick quantum dot photodetector using intercalated graphene monolayer electrodes.

Quantum dots (QDs) offer several advantages in optoelectronics such as easy solution processing, strong light absorption and size tunable direct bandgap. However, their major limitation is their poor film mobility and short diffusion length (<250 nm). This has restricted the thickness of QD film to ∼200-300 nm due to the restriction that the diffusion length imposes on film thickness in order to keep efficient charge collection.

FluPhenotype-a one-stop platform for early warnings of the influenza A virus.

Motivation: Newly emerging influenza viruses keep challenging global public health. To evaluate the potential risk of the viruses, it is critical to rapidly determine the phenotypes of the viruses, including the antigenicity, host, virulence and drug resistance.

Results: Here, we built FluPhenotype, a one-stop platform to rapidly determinate the phenotypes of the influenza A viruses.

Effect of Gene-Based Warfarin Dosing on Anticoagulation Control and Clinical Events in a Real-World Setting.

The and genotypes are associated with anticoagulation control and the clinical events in warfarin therapy. However, the clinical utility of gene-based warfarin dosing (GBWD) is controversial. We compared the anticoagulation control and clinical events related to warfarin with GBWD to those with clinically fixed dosing (CFD).

All-trans retinoic acid suppressed GES-1 cell proliferation induced by exosomes from patients with precancerous lesions by arresting the cell cycle in S-phase.

We aimed to detect the expression of specific LncRNAs in exosomes isolated from the serum of patients with precancerous lesions and to study the effect of these serum exosomes on the activity of GES-1 cells in patients with precancerous lesions, as well as the activity of all-trans retinoic acid on GES-1 cells with or without the exosomes. Exosomes were extracted from the serum of patients with precancerous lesions and normal controls. Based on our previous sequencing results, quantitative real time-PCR was used to detect differentially expressed LncRNAs.

Fabrication of MoO/MoC-Layered Hybrid Structures by Direct Thermal Oxidation of MoC.

Two-dimensional (2D) MoC, as a new member of transition metal carbides, has many intriguing properties and potential applications in superconductors and electronic devices. The thermal stability of 2D materials is essential for the performance of the related devices, especially the ones with a vertical heterostructure. However, rare reports have demonstrated the thermal stability of MoC and the effects of thermal stability on its performance.

Eutectic Synthesis of High-Entropy Metal Phosphides for Electrocatalytic Water Splitting.

High-entropy materials, a new class of alloys that incorporate five or more principal elements into single-phase crystal structures, have received considerable interest in materials science and engineering. Considering the tailored composition and disordered configuration, these high-entropy materials may arouse functional synergism towards electrocatalysis. Here, a new strategy for preparing high-entropy metal phosphides (HEMPs) was developed by a eutectic solvent method.

Crosstalk between Hh and Wnt signaling promotes osteosarcoma progression.

Objective: Osteosarcoma (OS) is the most common primary malignant tumor of bone. Patients with localized osteosarcoma are routinely treated with chemotherapy and surgery. However, many patients eventually relapse after these treatments.

The functions and targets of miR-212 as a potential biomarker of cancer diagnosis and therapy.

Cancer is a major health problem worldwide. An increasing number of researchers are studying the diagnosis, therapy and mechanisms underlying the development and progression of cancer. The study of noncoding RNA has attracted a lot of attention in recent years.

Longitudinal model-based meta-analysis for survival probabilities in patients with castration-resistant prostate cancer.

Purpose: The aims of this longitudinal model-based meta-analysis (MBMA) were to indirectly compare the time courses of survival probabilities and to identify corresponding potential significant covariates across approved drugs in patients with castration-resistant prostate cancer (CRPC).

Methods: A systematic literature review for monotherapy studies in patients with CRPC was conducted up to August 8, 2018. The time courses of progression-free survival (PFS) and overall survival (OS) were fitted with parametric survival models.

Gene-based anticoagulation regimens for an infant after mitral-valve replacement: A case report.

Rationale: Heart-valve replacement is one of the main surgical methods for various heart-valve diseases. Warfarin is the only oral anticoagulant used for thrombosis prevention after heart-valve replacement. However, warfarin has a narrow therapeutic window, large differences in efficacy between individuals, and can be affected by drugs, food and disease status.

Evaluation of the diagnostic value of circulating tumor cells with CytoSorter CTC capture system in patients with breast cancer.

Purpose: In this study, we aimed to investigate the viability of utilizing CytoSorter system to detect circulating tumor cells (CTCs) and to evaluate the diagnostic value of CTCs in breast cancer (BC).

Methods: A total of 366 females patients suspected of having BC and 30 healthy female volunteers were enrolled in this study. CTCs were enriched by CytoSorter , a microfluidic-based CTCs capturing platform.

ErbB4 knockdown in serotonergic neurons in the dorsal raphe induces anxiety-like behaviors.

There is a close relationship between serotonergic (5-HT) activity and anxiety. ErbB4, a receptor tyrosine kinase, is expressed in 5-HT neurons. However, whether ErbB4 regulates 5-HT neuronal function and anxiety-related behaviors is unclear.

Clinical efficacy analysis of Osimertinib treatment for a patient with leptomeningeal metastasis of EGFR+ non-small cell lung cancer without the T790M mutation.

Background: To find the method of therapy of leptomeningeal metastasis (LM) to non-small cell lung cancer (NSCLC) patient with EGFR mutation (EGFR+) but without T790M mutation.

Methods: A retrospective analysis was reviewed for 5 NSCLC patients with EGFR+ who develop to LM from January 2018 to February 2019 in our hospital.

Results: All five NSCLC cases were adenocarcinoma, four cases were verified existed EGFR mutation with 19 exon deletion in the first diagnosed by biopsy tissue, the other tissue was verified 21 exon mutation.

Optoelectronic response of hybrid PbS-QD/graphene photodetectors.

Lead sulfide quantum dots (QDs) have been widely used for various optoelectronic devices due to their high absorption coefficient and tunable bandgap. However, the low mobility of QD films results in poor charge collection and device performance. By combining QDs with graphene into hybrid graphene/QD photodetectors, photocarriers from QDs are transferred to graphene, improving charge collection and transport, drastically increasing the photoresponsivity.

Liver Soluble Epoxide Hydrolase Regulates Behavioral and Cellular Effects of Chronic Stress.

Major depression is a serious global health concern; however, the pathophysiology underlying this condition remains unclear. While numerous studies have focused on brain-specific mechanisms, few have evaluated the role of peripheral organs in depression. Here, we show that the liver activates an intrinsic metabolic pathway that can modulate depressive-like behavior.

Fabricating Amorphous g-CN/ZrO Photocatalysts by One-Step Pyrolysis for Solar-Driven Ambient Ammonia Synthesis.

Solar-driven nitrogen fixation remains a significant challenge. Graphitic carbon nitride (g-CN) is considered as a promising visible light photocatalyst. However, the photocatalytic performance of g-CN is unsatisfactory because of the random transfer of charge carriers in the plane and the low activation efficiency of the reactants.

Direct Patterning of Carbon Nanotube via Stamp Contact Printing Process for Stretchable and Sensitive Sensing Devices.

Flexible and wearable sensing devices have broad application prospects in bio-monitoring such as pulse measurement, motion detection and voice recognition. In recent years, many significant improvements had been made to enhance the sensor's performance including sensitivity, flexibility and repeatability. However, it is still extremely complicated and difficult to prepare a patterned sensor directly on a flexible substrate.