Immunization with OPN5 increased seasonal degradation of reproductive activity in Magang ganders.

To investigate the regulatory mechanism mediated by hypothalamic OPN5 on seasonal changes in the reproductive activities of domestic geese, 60 Magang ganders in their breeding period were selected for the experiment and evenly divided into an immunization group(OPN5-IM) and a control group. On days 0, 15 and 30, ganders in the immunized group were immunized with OPN5-KLH protein vaccine, and ganders in the control were immunized with the same amount of blank emulsified vaccine. Additionally, 120 female geese were provided to stimulate the reproductive activities of male geese.

Research progress of traditional Chinese medicine regulating intestinal flora in the treatment of hypertension.

Hypertension is a common disease; however, it is more prevalent in older adults, and its prevalence is increasing in younger populations. Numerous studies have revealed that hypertension and the composition and functionality of the intestinal flora are closely correlated. The balance of the intestinal flora, intestinal barrier integrity, and metabolite content of the intestinal flora play significant roles in the occurrence and progression of hypertension.

KDELR1 regulates chondrosarcoma drug resistance and malignant behavior through Intergrin-Hippo-YAP1 axis.

Chondrosarcoma (CS) is the second most common primary bone malignancy, known for its unique transcriptional landscape that renders most CS subtypes resistant to chemotherapy, including neoadjuvant chemotherapy commonly used in osteosarcoma (OS) treatment. Understanding the transcriptional landscape of CS and the mechanisms by which key genes contribute to chemotherapy resistance could be a crucial step in overcoming this challenge. To address this, we developed a single-cell transcriptional map of CS, comparing it with OS and normal cancellous bone.

Evidence-Based Leadership in Nursing: An Evolutionary Concept Analysis.

Aim: To conduct a concept analysis of evidence-based leadership in a nursing context.

Methods: Rodgers' evolutionary method was employed to identify attributes, antecedents, consequences, definitions and surrogate and related terms.

Data Source: We systematically searched three databases (PubMed, Cumulative Index to Nursing and Allied Health Literature and Scopus) for relevant publications.

Serum Progesterone Level on the Day of Embryo Transfer Is Not a Reliable Predictor for Frozen-Thawed Embryo Transfer Outcomes With Euploid Blastocyst Transfer: A Retrospective Cohort Study.

Objective: To investigate whether serum progesterone (P4) levels on embryo transfer (ET) day correlate with the likelihood of live birth in artificial frozen-thawed transfer cycles using intramuscular progesterone.

Design: Retrospective cohort study.

Setting: University-affiliated hospital.

MdLRR-RLK1-MdATG3 module enhances the resistance of apples to abiotic stress via autophagy.

Apple is an important economic species affected by abiotic stress, such as salt and drought. LRR-RLKs play a key role in plant responses to stress, although their physiological functions under abiotic stress are not yet fully understood. Autophagy is a highly conserved process in eukaryotes, which plays a vital role in drought and salt stress responses.

Towards better care: Comprehensive review of patient-reported patient engagement instruments in healthcare.

Objective: Patient engagement is widely recognized as essential for improving healthcare quality and reducing costs; however, its formal evaluation presents significant challenges. The aim of this review was to assess instruments for measuring patient engagement in healthcare from the patients' perspective and to evaluate their psychometric properties.

Methods: A systematic review according to the PRISMA guidelines was conducted to evaluate the psychometric properties of patient-reported questionnaires assessing patient engagement.

Intracellular autoactivation and surface location of hepsin, TMPRSS2, and TMPRSS13.

Aims: Hepsin (HPN), a Type II transmembrane serine protease (TTSP), is involved in hepatocyte metabolism and various diseases. It undergoes autoactivation on the surface of human hepatoma cells, a mechanism not observed in other cell types. This study aims to explore HPN activation and surface expression in endometrial epithelial cells.

Metabolically intact nuclei are fluidized by the activity of the chromatin remodeling motor BRG1.

The structure and dynamics of the nucleus regulate cellular functions, with shape changes impacting cell motility. Although the nucleus is generally seen as the stiffest organelle in the cell, cells can nevertheless deform the nucleus to large strains by small mechanical stresses. Here, we show that the mechanical response of the cell nucleus exhibits active fluidization that is driven by the BRG1 motor of the SWI/SNF/BAF chromatin remodeling complex.

Mechanochemical activation of 2D MnPS for sub-attomolar sensing.

Molecular detection is important in biosensing, food safety, and environmental surveillance. The high biocompatibility, superior mechanical stability, and low cost make plasmon-free surface-enhanced Raman scattering (SERS) a promising sensing technique, the ultrahigh sensitivity of which is urgently pursued for realistic applications. As a proof of concept, we report a mechanochemical strategy, which combines the wrinkling and chemical functionalization, to fabricate a plasmon-free SERS platform based on 2D MnPS with a sub-attomolar detection limit.

BMSC Derived Exosomes Attenuate Apoptosis of Temporomandibular Joint Disc Chondrocytes in TMJOA via PI3K/AKT Pathway.

Bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exos) are crucial means of intercellular communication and can regulate a range of biological processes by reducing inflammation, decreasing apoptosis and promoting tissue repair. We treated temporomandibular joint (TMJ) disc chondrocytes with TNF-α and performed local injection of sodium iodoacetate (MIA) in the TMJ of rats to establish in vitro and in vivo models of TMJ osteoarthritis (TMJOA). BMSC-Exos were isolated and extracted to evaluate their proliferation and trilineage differentiation abilities, and their antiapoptotic and chondroprotective effects were assessed.

Spatial benefit assessment and marine climate response of coastal zone in Fujian Province under cross-system influence.

To gain a scientific understanding of the cross-system impact of coastal zones and promote the sustainable development and protection of coastal areas, we constructed a spatial benefit evaluation system that encompassed both terrestrial and marine systems, focusing on the ecological, economic, and social dimensions. We employed the entropy method, moving average method, and Mann-Kendall trend test to quantitatively characterize the spatial benefits of the coastal zone in Fujian Province, China, and the evolution of the marine climate from 2005 to 2020. Building on this, the grey relational analysis method was applied to investigate the correlation between spatial benefits and marine climate and to explore the trends and magnitude of the impact of marine climate on spatial benefits.

Distinct septo-hippocampal cholinergic projections separately mediate stress-induced emotional and cognitive deficits.

Patients suffering from chronic stress develop numerous symptoms, including emotional and cognitive deficits. The precise circuit mechanisms underlying different symptoms remain poorly understood. We identified two distinct basal forebrain cholinergic subpopulations in mice projecting to the dorsal hippocampus (dHPC) or ventral hippocampus (vHPC), which exhibited distinct input organizations, electrophysiological characteristics, transcriptomics, and responses to positive and negative valences of stimuli and were critical for cognitive and emotional modulation, respectively.

Online training to improve evidence-based leadership competencies among nurse leaders in China: a feasibility randomised controlled trial.

Objective: To evaluate the feasibility of an online evidence-based leadership training programme for nurse leaders and its potential effectiveness in improving nurse leaders' evidence-based leadership competencies.

Design: This is a two-arm, parallel, feasibility randomised controlled trial.

Methods: We screened all 160 nurse leaders from two Chinese hospitals.

Association of prophylactic low-dose aspirin use with all-cause and cause-specific mortality in cancer patients.

The long-term use of aspirin for preventing cardiovascular disease has been recommended for decades. However, there is currently uncertainty regarding the long-term effects of aspirin use on the risk of all-cause, cardiovascular, and cancer mortality in cancer patients. The aim of this work was to analyze the connection between the prophylactic use of low-dose aspirin and the risk of all-cause death, cardiovascular death, and carcinoma death in carcinoma patients in the United States.

Microplastic Transport and Accumulation in Rural Waterbodies: Insights from a Small Catchment in East China.

Microplastic (MP) pollution in agricultural ecosystems is an emerging environmental concern, with limited knowledge of its transport and accumulation in rural waterbodies. This study investigates the distribution and sources of MP in drainage ditches influenced by pond connectivity, land use, and soil properties within a small catchment in Nanjing, East China. Sediment was collected from ditches in 18 sites across forest, agricultural, horticultural, and urban areas.

Organizational evidence-based practice culture, implementation leadership, and nurses: A bidirectional mediation model.

Aim: This study aimed to explore 1) factors that influenced the evidence-based practice competencies and behaviors of clinical nurses and 2) the interaction between the organizational evidence-based practice culture, head nurses' implementation leadership, and nurses' evidence-based practice competencies and behaviors.

Background: The significance of organizational evidence-based practice culture and head nurses' implementation leadership in enhancing nurses' evidence-based practice competencies and behavior is widely recognized in healthcare settings. However, there is limited knowledge of how these factors influence nurses' evidence-based practice competencies and behavior.

DNA barcoding and cryptic diversity in fishes from the Ili River Valley in China, Xinjiang.

The Ili River Valley, located in the northwest of China, serves as a vital repository for fish genetic resources. Its extensive water network and diverse climate have given rise to a unique fish composition and endemic species. In this study, we collected the cytochrome c oxidase subunit I (COI) sequences from 660 fish specimens in the Ili River Valley.

Coaching to develop leadership of healthcare managers: a mixed-methods systematic review.

Introduction: Coaching is commonly used to facilitate leadership development among healthcare managers. However, there is limited knowledge of the components of coaching interventions and their impacts on healthcare managers' leadership development. This mixed-methods systematic review aimed to synthesize evidence of coaching to develop leadership among healthcare managers.

Phloretin alleviates sleep deprivation-induced cognitive impairment by reducing inflammation through PPARγ/NF-κB signaling pathway.

Sleep loss leads to significant pathophysiological consequences, including cognitive impairment. The neuroinflammation are pivotal factors in the pathogenesis of cognitive impairment induced by sleep loss. The phloretin (PHL), derived from peel of juicy fruits, has demonstrated potent anti-inflammatory properties.