Effects of Bacillus coagulans on kidney injury caused by Klebsiella pneumoniae in rabbits.

Klebsiella pneumoniae (KP) is a zoonotic conditionally pathogenic bacterium with a high prevalence of infection. It often induces purulent inflammation of the rabbit lungs, kidneys and other tissues, with high morbidity and mortality. Bacillus coagulans (BC) has the ability to regulate the balance of host intestinal flora and improve host immunity.

Identification of novel ABCB4 variants and genotype-phenotype correlation in progressive familial intrahepatic cholestasis type 3.

Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a severe hepatic disorder characterized by cholestasis. Elucidating the genotype-phenotype correlations and expanding the mutational spectrum of the ABCB4 gene are crucial for enhancing diagnostic accuracy and therapeutic strategies.Clinical and genetic data from 2 original PFIC3 patients from our institution, along with 118 additional cases identified through a comprehensive literature review, were integrated for a comprehensive analysis.

Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review.

Zearalenone (ZEA) is a mycotoxin produced by Fusarium spp. fungi and is widely found in moldy corn, wheat, barley, and other grains. ZEA is distributed to the whole body via blood circulation after metabolic transformation in animals.

Long-term inhalation exposure: A model for phthalate accumulation in the respiratory tract.

Background: Inhalation is a major pathway for phthalates (PAEs), an endocrine disruptor, to enter the human body. The actual internal exposure amount that participates in metabolism cannot be estimated by calculating total inhalation intake.

Objective: To estimate the accumulation in each region of the respiratory tract after long-term exposure to PAEs in different populations.

Liver regeneration after injury: Mechanisms, cellular interactions and therapeutic innovations.

The liver possesses a distinctive capacity for regeneration within the human body. Under normal circumstances, liver cells replicate themselves to maintain liver function. Compensatory replication of healthy hepatocytes is sufficient for the regeneration after acute liver injuries.

PLAUR facilitates the progression of clear cell renal cell carcinoma by activating the PI3K/AKT/mTOR signaling pathway.

Background: PLAUR has been found upregulated in various tumors and closely correlated with the malignant phenotype of tumor cells. The aim of this study was to investigate the relationship between PLAUR and clear cell renal cell carcinoma (ccRCC) and its potential mechanism of promoting tumor progression.

Methods: The expression levels and clinical significance of PLAUR, along with the associated signaling pathways, were extensively investigated in ccRCC samples obtained from The Cancer Genome Atlas (TCGA).

Identification of several African swine fever virus replication inhibitors by screening of a library of FDA-approved drugs.

African swine fever (ASF) caused by African swine fever virus (ASFV) is a highly infectious and lethal swine disease. Currently, there is only one novel approved vaccine and no antiviral drugs for ASFV. In the study, a high-throughput screening of an FDA-approved drug library was performed to identify several drugs against ASFV infection in primary porcine alveolar macrophages.

Antibiotic resistance of in Nanjing, China: a cross-section study from 2018 to 2023.

Background: The increasing prevalence of antibiotic resistance in cases of () infection has emerged as a significant global issue. This study offers a comprehensive examination of the alterations in drug resistance exhibited by in the Nanjing region of China during the preceding five years. Another important objective is to investigate the influence of levofloxacin medication history on genotypic and phenotypic resistance.

Diagnostic accuracy of a novel optical coherence tomography-based fractional flow reserve algorithm for assessment of coronary stenosis significance.

Background: This study aimed to introduce a novel optical coherence tomography-derived fractional flow reserve (FFR) computational approach and assess the diagnostic performance of the algorithm for assessing physiological function.

Methods: The fusion of coronary optical coherence tomography and angiography was used to generate a novel FFR algorithm (AccuFFRoct) to evaluate functional ischemia of coronary stenosis. In the current study, a total of 34 consecutive patients were included, and AccuFFRoct was used to calculate the FFR for these patients.

Total Glucosides of Paeony Ameliorate Myocardial Injury in Chronic Heart Failure Rats by Suppressing PARP-1.

Total glucosides of paeony (TGP) have a potential protective effect on chronic heart failure (CHF) rats, but the mechanism remains unclear. PARP inhibition prevents the decrease in myocardial contractility. Therefore, we aim to investigate the effects and mechanisms of TGP on CHF and the role of PARP-1 in CHF.

A novel signaling transduction pathway of melatonin on lactose synthesis in cows via melatonin receptor 1 (MT1) and prolactin receptor (PRLR).

In the current study, we explored the relationship between melatonin and lactose synthesis in and conditions. We found that long-term melatonin feeding to the dairy cows significantly reduced the milk lactose content in a dose dependent manner. This lactose reduction was not associated with a negative energy balance, since melatonin treatment did not alter the fat, glucose, or protein metabolisms of the cows.

Calculation of excited states of monolayer TPPA-COF based on first principles.

Two-dimensional covalent organic frameworks (COFs) have always been a hot topic in condensed matter physics. Herein, the first 100 excited states of the TPPA-COF are calculated to investigate the optical absorption properties of the materials in the interval. The stable molecular structure of monolayer TPPA-COF is obtained by first-principles calculation, which can be regarded as a hexagon with an aperture size of 18.

Intravascular Ultrasound-Based Fractional Flow Reserve for Predicting Prognosis after Percutaneous Coronary Intervention.

AccuFFRivus is an alternative to fractional flow reserve (FFR) based on intravascular ultrasound (IVUS) images for functional assessment of coronary stenosis. However, its prognostic impact in patients undergoing percutaneous coronary intervention (PCI) is still unclear. This retrospective study aimed to investigate the capability of AccuFFRivus in predicting prognosis.

Impact of Climate Change on Indoor Air Quality: A Review.

Climate change can affect the indoor environment due to heat and mass transfers between indoor and outdoor environments. To mitigate climate change impacts and adapt buildings to the changing environment, changes in building characteristics and occupants' behavior may occur. To characterize the effects of climate change on indoor air quality (IAQ), the present review focused on four aspects: (1) experimental and modeling studies that relate IAQ to future environmental conditions, (2) evolution of indoor and outdoor air concentrations in the coming years with regard to temperature rise, (3) climate change mitigation and adaptation actions in the building sector, and (4) evolution of human behavior in the context of climate change.

Durable and Nontoxic Natural Rubber-Based Composites with Antibacterial Properties.

Natural rubber latex (NRL) has prophylactic properties and is used to make pathogen-isolating products like condoms and surgical gloves. However, obtaining NRL and casting it into durable products are challenging. Consequently, progress in the research and development of medical NRL products has been slow.

Dielectric Relaxation and Dielectric Switching Behaviors in (N,N-Diisopropylethylamine) Tetrachloroantimonate(III).

Dielectric switches have drawn renewed attention to the study of their many potential applications with the adjustable switch temperatures (T ). Herein, a novel antimony-based halide semiconductor, (N,N-diisopropylethylamine) tetrachloroantimonate ((DIPEA)SbCl , DIPEA =N,N-diisopropylethylamine), with dielectric relaxation behavior and dielectric switches has been successfully synthesized. This compound, consisting of coordinated anion chains and isolated DIPEA cations, undergoes an isostructural order-disorder phase transition and shows a step-like dielectric anomaly, which can function as a frequency-tuned dielectric switch with highly adjustable switch temperature (T ).

Super solvent of cellulose with extra high solubility for tunable cellulose structure with versatile application.

Low-temperature two-step concentrated HSO was discovered to be a solvent with high cellulose solubility [>300 g/L (17 wt%)], fast cellulose dissolution, high regeneration yield (>0.92 g/g), and cellulose being mouldable during regeneration. The superior performance was enabled by the much better compatibility of cellulose with lower concentrated HSO at low temperature, compared with that of high concentrated HSO.

Fabrication and DFT Calculation of Amine-Functionalized Metal-Organic Framework as a Turn-On Fluorescence Sensor for Fe and Al Ions.

Due to their important role in biological systems, it is urgent to develop a material that can rapidly and sensitively detect the concentration of Fe and Al ions. In this work, a brand-new Cd-based metal-organic framework [Cd(BTBD)(AIC)] (, BTBD = 4,7-bis(1-1,2,4-triazol-1-yl)-2,1,3-benzothiadiazole and HAIC = 5-aminoisophthalic acid) with a 4-connected topology was designed and synthesized. The symmetrical Cd centers are linked by AIC ligands with μ-η:η:η:η coordination mode to form a [Cd(COO)] secondary building unit (SBU).

Measurement methods and impact factors for the key parameters of VOC/SVOC emissions from materials in indoor and vehicular environments: A review.

The emissions of volatile organic compounds (VOCs) and semi-volatile organic compounds (SVOCs) from indoor building and vehicle cabin materials can adversely affect human health. Many mechanistic models to predict the VOC/SVOC emission characteristics have been proposed. Nowadays, the main obstacle to accurate model prediction is the availability and reliability of the physical parameters used in the model, such as the initial emittable concentration, the diffusion coefficient, the partition coefficient, and the gas-phase SVOC concentration adjacent to the material surface.

PTBP-1 and TNF-α/NF-κB are involved in repair mechanisms of human umbilical cord mesenchymal stem cell transplantation in mice with spinal cord injury.

Objectives: To explore the possible mechanism of human umbilical cord mesenchymal stem cell (hUC-MSC) transplantation in mice after spinal cord hemisection.

Methods: Thoracic spinal cord hemisection injuries were performed on adult female Kunming mice. The mice with spinal cord injury (SCI) were injected with hUC-MSCs suspended in normal saline, while the control mice received an equal volume of normal saline.

The Variance of Photophysical Properties of Tetraphenylethene and Its Derivatives during Their Transitions from Dissolved States to Solid States.

The study of aggregation-induced emission luminogens (AIEgens) shows promising perspectives explored in lighting, optical sensors, and biological therapies. Due to their unique feature of intense emissions in aggregated solid states, it smoothly circumvents the weaknesses in fluorescent dyes, which include aggregation-caused quenching of emission and poor photobleaching character. However, our present knowledge of the AIE phenomena still cannot comprehensively explain the mechanism behind the substantially enhanced emission in their aggregated solid states.

[Progress in replicative senescence of mesenchymal stem cells regulated by microenvironment].

Mesenchymal stem cells (MSCs) are a class of pluripotent cells that can self-renew and differentiate. Numerous studies have shown that MSCs have important roles in areas such as regenerative medicine and tissue engineering. However, it is worth noting that MSCs will gradually age during long-term in vitro expansion with decreased stemness such as weakened migration ability, slowed proliferation rate and decreased differentiation potential, which greatly hinders the application of MSCs.