Discrimination of superficial lymph nodes using ultrasonography and tissue metabolomics coupled with machine learning.

Introduction: Diagnosing the types of malignant lymphoma could help determine the most suitable treatment, anticipate the probability of recurrence and guide long-term monitoring and follow-up care.

Methods: We evaluated the differences in benign, lymphoma and metastasis superficial lymph nodes using ultrasonography and tissue metabolomics.

Results: Our findings indicated that three ultrasonographic features, blood supply pattern, cortical echo, and cortex elasticity, hold potential in differentiating malignant lymph nodes from benign ones, and the shape and corticomedullary boundary emerged as significant indicators for distinguishing between metastatic and lymphoma groups.

Smooth braking control of excavator hydraulic load based on command reshaping.

Excavators, a type of human-operated construction machinery, suffer from poor hydraulic load braking stability, which seriously affects operator comfort. To address this challenge, this study investigates load braking laws through model analysis and designs an open-loop control algorithm called command reshaping, which can prolong the small-opening time of the main valve by segmentally adjusting the joystick command during load braking and then actively adjusting the key parameters reflecting the system's kinetic-potential energy state, thereby suppressing braking oscillations. The experimental results based on a 1.

[Analysis of temporomandibular joint imaging and orthodontic effect in patients with introverted deep overbite and severe attrition].

Purpose: To investigate the functional and structural characteristics of temporomandibular joint(TMJ) in introverted deep overbite patients with severe wear, to analyze the correlation between the vertical distance of the lower 1/3 of the face and TMJ space, and to compare the clinical efficacy of multidisciplinary treatment with orthodontics and prosthodontics on TMJ function.

Methods: Eighty patients with deep overbite and severe abrasion and forty subjects with normal occlusion admitted to our hospital from January 2019 to June 2023 were enrolled in this study. The clinical data were collected and the functional and structural characteristics of TMJ were collected.

New insights into the charge property at active sites boost PMS activation over LaFeMnO.

Perovskite-based materials have become a new direction for peroxymonosulfate (PMS) activation in pollutants degradation. However, the mechanism towards PMS activation remains insufficient. In this paper, a series of LaMMnO materials with B-site doping were developed by sol-gel self-propagating combustion method.

Multimodality high-frequency ultrasound in the evaluation of cervical malignant lymphoma before biopsy.

Objective: To investigate the application value of multimodality ultrasound in the evaluation of lymphoma.

Methods: The regression models were performed to determine whether there were differences in differentiating lymphoma from benign lymph nodes. Receiver operator curves were drawn to evaluate the diagnostic performance of three ultrasound modalities.

Performance of a Novel Muscle Synergy Approach for Continuous Motion Estimation on Untrained Motion.

When applying continuous motion estimation (CME) model based on sEMG to human-robot system, it is inevitable to encounter scenarios in which the motions performed by the user are different from the motions in the training stage of the model. It has been demonstrated that the prediction accuracy of the currently effective approaches on untrained motions will be significantly reduced. Therefore, we proposed a novel CME method by introducing muscle synergy as feature to achieve better prediction accuracy on untrained motion tasks.

[Improvement of the mastication function of orthodontics combined with restoration in the treatment of deep overbite with severe lower anterior teeth attrition].

Purpose: To observe the effect of orthodontics combined with restoration on masticatory function in deep overbite patients with severe lower anterior teeth attrition.

Methods: From January 2018 to January 2022, a total of 164 deep overbite patients with severe lower anterior teeth attrition were collected and divided into two groups according to different treatment plans: control group(72 patients, with restoration treatment) and experimental group(92 patients, with orthodontics combined with restoration treatment). The chewing efficiency of the two groups was evaluated, temporomandibular joint dysfunction index (DI), muscle palpation index (PI) and cranio-mandibular index (CMI) were calculated.

Analysis of early response to chemotherapy for non-Hodgkin's lymphoma by quantitative contrast-enhanced ultrasound: A prospective case-control crossectional study.

Objective: To investigate the value of quantitative contrast-enhanced ultrasonography (CEUS) in assessing and predicting early therapy response of non-Hodgkin's lymphoma (NHL).

Methods: Fifty-six cases of NHL were studied using CEUS before and after three cycles of R-CHOP / CHOP. Quantitative parameters such as arrival time (ATM), time to peak (TTP), △T = TTP-ATM, area under the gamma curve (Area), curve gradient (Grad), wash-out time (WT), base intensity (BI), peak intensity (PI) and ΔI = PI-BI were compared between the lymphoma and normal lymph nodes before and at mid-treatment, respectively.

[Clinical study of the effect of combined orthodontic and restoration treatment for introverted deep overbite patients with severe wear].

Purpose: To investigate the effectiveness of combined orthodontic and restoration treatment for introverted deep overbite patients with severe wear.

Methods: A total of 86 introverted deep overbite patients with severe wear admitted to Cangzhou People's Hospital from December 2020 to June 2022 were collected and divided into the control group and the experimental group by gender, age, degree of wear and tear, with 43 cases in each group. The control group received orthodontic treatment, while the experimental group received combined orthodontic and restoration treatment.

[Recent developments in the application of covalent organic frameworks in capillary electrochromatography].

Capillary electrochromatography (CEC) has received increased attention from the academic community because it combines the excellent selectivity of high performance liquid chromatography (HPLC) and the high efficiency of capillary electrophoresis (CE). Selecting the most appropriate stationary phase material is crucial to achieve better separation effects in CEC. In recent years, a considerable number of materials, such as graphene oxide, proteins, metal organic frameworks, and covalent organic frameworks (COFs), have been widely used as stationary phases in CEC to further improve its separation performance and extend its scope of potential applications.

The role of ultrasound quantitative parameters in the assessment of acute radiodermatitis after breast-conserving surgery.

This study aimed to assess the severity of acute radiodermatitis (ARD) by ultrasound quantitative parameters and to try to identify the influencing factors of skin toxicity. A total of 55 patients who underwent radiotherapy after unilateral breast-conserving surgery (BCS) were included in the study. The irradiated side of the breast was used as the research object and the quantitative ultrasound parameters (skin thickness, shear wave elasticity) were evaluated before radiotherapy, every week during radiotherapy.

Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications.

Peroxynitrite (ONOO), owing to its high oxidative and nitrating stress, is associated with several physiological processes in addition to various pathological processes, including those related to neurodegenerative diseases and cancer. Detection of ONOO at the cellular level is of great significance to understand its pathogenesis. To this end, a variety of fluorescent probes based on small molecules and nanoparticles (NPs) have been engineered and applied as excellent tools for imaging of ONOO in cells as well as in their diverse biological applications.

Extraction of Gold Based on Ionic Liquid Immobilized in UiO-66: An Efficient and Reusable Way to Avoid IL Loss Caused by Ion Exchange in Solvent Extraction.

Ionic liquids (ILs) have received considerable attention as a promising green solvent for extracting metal ions from aqueous solutions. However, the recycling of ILs remains difficult and challenging because of the leaching of ILs, which is caused by the ion exchange extraction mechanism and hydrolysis of ILs in acidic aqueous conditions. In this study, a series of imidazolium-based ILs were confined in a metal-organic framework (MOF) material (UiO-66) to overcome the limitations when used in solvent extraction.

A model to predict the prognosis of diffuse large B-cell lymphoma based on ultrasound images.

The purpose of this paper was to assess the value of ultrasonography in the prognosis of diffuse large b-cell lymphoma (DLBCL) by developing a new prognostic model. One hundred and eleven DLBCL patients with complete clinical information and ultrasound findings were enrolled in our study. Univariate and multivariate regression analyses were used to identify independent risk factors for progression-free survival (PFS) and overall survival (OS).

Development and validation of nomograms by radiomic features on ultrasound imaging for predicting overall survival in patients with primary nodal diffuse large B-cell lymphoma.

Objectives: To develop and validate a nomogram to predict the overall survival (OS) of patients with primary nodal diffuse large B-cell lymphoma(N-DLBCL) based on radiomic features and clinical features.

Materials And Methods: A retrospective analysis was performed on 145 patients confirmed with N-DLBCL and they were randomly assigned to training set(n=78), internal validation set(n=33), external validation set(n=34). First, a clinical model (model 1) was established according to clinical features and ultrasound (US) results.

Stable Ultrathin Ag Electrodes by Tailoring the Surface of Plastic Substrates for Flexible Organic Light-Emitting Devices.

Flexible transparent metal electrodes (FTMEs) have significant application potentials in the fields of flexible optoelectronic devices due to their outstanding optical transmittance and electrical conductivity. However, obtaining excellent optoelectrical properties and mechanical flexibility of FTMEs is challenging because ultrathin metal layers usually follow an island growth mode. In this paper, flexible transparent ultrathin Ag electrodes with high mechanical stability and good optoelectrical properties were exploited by tailoring the surface properties of plastic substrates with ultraviolet-ozone (UVO) treatment for regulating the nucleation and growth kinetics of Ag films.

The design strategies and biological applications of probes for the gaseous signaling molecule hydrogen sulfide.

HS, the smallest and simplest biological thiol in living systems, is the third member of the family of signaling mediators. HS participates in the regulation of a series of complex physiological and pathological functions in the body, making it a critical fulcrum that balances health and disease in human physiology. Small-molecule fluorescent probes have been proven to possess the unique advantages of high temporal and spatial resolution, good biocompatibility and high sensitivity, and thus their use is a powerful approach for monitoring the level and dynamics of HS in living cells and organisms and better understanding its basic cellular functions.

Transdermal delivery of inflammatory factors regulated drugs for rheumatoid arthritis.

Rheumatoid arthritis is a chronic autoimmune disease, with the features of recurrent chronic inflammation of synovial tissue, destruction of cartilage, and bone erosion, which further affects joints tissue, organs, and systems, and eventually leads to irreversible joint deformities and body dysfunction. Therapeutic drugs for rheumatoid arthritis mainly reduce inflammation through regulating inflammatory factors. Transdermal administration is gradually being applied to the treatment of rheumatoid arthritis, which can allow the drug to overcome the skin stratum corneum barrier, reduce gastrointestinal side effects, and avoid the first-pass effect, thus improving bioavailability and relieving inflammation.

Exposure effects of inhaled nickel nanoparticles on the male reproductive system via mitochondria damage.

Nickel nanoparticles (Ni NPs) have a wide range of application prospects, however there is still a lack of their safety evaluation for the reproductive system. Nowadays, male reproductive health has been widely concerned for the increasing incidence of male infertility. To investigate the male reproductive toxicity induced by Ni NPs and its relation with the mitochondrial fission and mitophagy, male mice were administered with or without 5, 15, and 45 mg/kg of Ni NPs by intratracheal instillation.

Diagnostic value of thyroid imaging reporting and data system combined with BRAF mutation analysis in Bethesda categories III-V thyroid nodules.

Fine needle aspiration biopsy is a crucial method for preoperative diagnosis of thyroid nodules. However, thyroid nodules classified as Bethesda categories III-V cannot obtain definite cytological results. Our aim was to study the diagnostic value of thyroid imaging reporting and data system combined with BRAF mutation analysis in Bethesda categories III-V thyroid nodules, so as to provide more precise direction for the follow-up treatments.

Fabrication of Curcumin@Ag Loaded Core/Shell Nanofiber Membrane and its Synergistic Antibacterial Properties.

The core/shell structure nanofiber membrane loaded with curcumin and silver nanoparticles was prepared by coaxial electrospinning technology, which is a high-efficiency combined antibacterial material composed of photodynamic antibacterial agent and metal nanoparticle. As a photosensitizer, curcumin could generate singlet oxygen under laser irradiation. Silver nanoparticles have antibacterial properties, and could also enhance the singlet oxygen production of curcumin due to the metal-enhanced singlet oxygen effect, thereby producing a synergistic antibacterial effect.

Advanced glycation end products promote osteoporosis by inducing ferroptosis in osteoblasts.

Advanced glycation end products (AGEs) have been widely reported to play an important role in osteoporosis (OP), particularly in diabetes‑related OP. The aim of the present study was to investigate the effect of AGEs on osteoblast function and the underlying mechanisms. The level of bone mineral density (BMD), serum AGEs and fasting blood glucose (FBG) was measured in patients with OP and healthy individuals, and the correlation between AGE levels and BMD or FBG was then analyzed.

Comparison Studies on Several Ligands Used in Determination of Cd(II) in Rice by Flame Atomic Absorption Spectrometry after Ultrasound-Assisted Dispersive Liquid-Liquid Microextraction.

Ligands plays an important role in the extraction procedures for the determination of cadmium in rice samples by using flame atomic absorption spectrometry (FAAS). In the present study, comparative evaluation of 10 commercially available ligands for formation of Cd(II)-ligand complex and determination of cadmium in rice samples by ultrasound-assisted dispersive liquid-liquid microextraction (UADLLME) combined with FAAS was developed. Sodium diethyldithiocarbamate (DDTC) provided a high distribution coefficient as well as a good absorbance signal, therefore DDTC was used as a ligand in UADLLME.

Study of the mechanism of mitochondrial division and mitochondrial autophagy in the male reproductive toxicity induced by nickel nanoparticles.

Male reproductive health is deteriorating, and fertility is largely affected by environmental factors. This study aims to investigate the potential mechanism underlying mitochondrial division and mitochondrial autophagy in the male reproductive toxicity of nickel nanoparticles (Ni NPs). An mouse (BALB/c) model was constructed to calculate testicular organ coefficients and sperm abnormality rates, and detect serum reproductive hormones, testicular pathological morphology, and the expression of Drp1, Pink1, and Parkin proteins.

Highly Efficient Inverted Organic Light-Emitting Diodes Adopting a Self-Assembled Modification Layer.

Inverted organic light-emitting diodes (IOLEDs) can be integrated with low-cost n-channel thin-film transistors for use in active-matrix OLEDs (AMOLEDs). However, the electron injection from conventional indium tin oxide (ITO) cathode to the upper electron transport layer usually suffers from a large injection barrier. To improve the electron injection efficiency, the electron injection layers (EILs) of ZnO modified by a self-assembled monolayer arginine (Arg) were developed to construct efficient IOLEDs.