Elevated body roundness index increases the risk of cardiovascular disease in Chinese patients with circadian syndrome.

Objective: The body roundness index (BRI) and circadian syndrome (CircS) are considered new risk factors for cardiovascular disease (CVD), yet it remains uncertain whether elevated BRI is associated with CVD incidence in CircS patients. In this study, we investigated the association between BRI and CVD occurrence among CircS participants.

Methods: We conducted a retrospective cohort study involving 8,888 participants aged ≥45 years from the China Health and Retirement Longitudinal Study (CHARLS 2011-2020 wave).

PmAm, a broad-spectrum powdery mildew resistance source located on chromosome 6T, is transferred to common wheat.

Powdery mildew (caused by Blumeria graminis f. sp. tritici) limits grain production and reduces grain quality in wheat.

Global Burden of Major Chronic Liver Diseases in 2021.

Background: This study utilised the Global Burden of Disease data (2010-2021) to analyse the rates and trends in point prevalence, annual incidence and years lived with disability (YLDs) for major chronic liver diseases, such as hepatitis B, hepatitis C, metabolic dysfunction-associated liver disease, cirrhosis and other chronic liver diseases.

Methods: Age-standardised rates per 100,000 population for prevalence, annual incidence and YLDs were compared across regions and countries, as well as the socio-demographic index (SDI). Trends were expressed as percentage changes (PC) and estimates were reported with uncertainty intervals (UI).

In-situ integrated Ce-MOF-808@CeO as bifunctional matrix for sensitive electrochemical-aptasensing of tetracycline in shrimp.

The integration of aptamer chemistry with innovative functional materials such as nanozymes offers new opportunities for the development of the superior electrochemical biosensors. Herein, we introduce a rod-like nanocomposite of Ce-MOF-808@CeO bearing intense nanozymatic activity that prepared through in-situ partial oxidation of Ce-MOF-808 to CeO. Then, the aptamer for tetracycline (TC-Apt) with 5'-PO end was anchored on Ce-MOF-808@CeO modified screen-printed electrode, thereby assembling a label-free electrochemical aptasensor.

3D printed porous magnesium metal scaffolds with bioactive coating for bone defect repair: enhancing angiogenesis and osteogenesis.

In orthopedics, the effective treatment of bone defects remains a major challenge. Magnesium (Mg) metals, with their excellent biocompatibility and favorable osteoconductivity, osteoinductivity, and osseointegration properties, hold great promise for addressing this issue. However, the rapid degradation rate of magnesium restricts its clinical application.

Knocking out artificially selected gene GmAOC4 improves germination in soybean.

Seed germination is an essential stage in the life cycle of flowering plants, influencing the field emergence rates of seeds. Consequently, the role of GmAOC4 in soybean seed germination was investigated in the present study. Results suggested that the chloroplast-localized GmAOC4 exhibited high expression levels in the roots and young pods and during the seed germination stage in soybeans.

Compound kushen injection improves radiation enteritis via cannabinoid receptor 1 in rats.

Background: Clinical studies have shown that Compound Kushen Injection (CKI) can alleviate the inflammatory symptoms of radiation enteritis. However, the mechanism of action remains unclear. The aim of this study was to explore the possible targets and mechanisms of CKI in the treatment of radiation enteritis.

Hemodynamic and Pharmacokinetic Interactions of TPN171 with Alcohol in Healthy Male Subjects.

This study aimed to evaluate the effects of the concomitant administration of TPN171 and alcohol on hemodynamic and pharmacokinetic characteristics in healthy Chinese male subjects. Fifteen eligible subjects were randomly assigned to one of three sequences, each comprising three treatments: Treatment A (placebo +0.5 g/kg alcohol), Treatment B (TPN171 + 0.

β-Hydroxybutyrate Facilitates Postinfarction Cardiac Repair via Targeting PHD2.

Background: Acute myocardial infarction (MI) remains one of the major causes of death worldwide, and innovative treatment strategies for MI represent a major challenge in cardiovascular medicine. Caloric restriction (CR) is the most potent nonpharmacological intervention known to prevent age-related disorders and extend lifespan. CR reduces glycolysis and elevates ketone body metabolism.

Reproductive Toxicity of Zearalenone and Its Molecular Mechanisms: A Review.

Zearalenone (ZEA) is one of the common mycotoxins in feeds. ZEA and its metabolites have estrogen-like activity and can competitively bind to estrogen receptors, causing reproductive dysfunction and damage to reproductive organs. The toxicity mechanism of ZEA mainly inhibits the antioxidant pathway and antioxidant enzyme activity, induces cell cycle arrest and DNA damage, and blocks the process of cellular autophagy to produce toxic effects.

A computer-aided, carrier-free drug delivery system with enhanced cytotoxicity and biocompatibility: A universal model for multifunctional lung cancer therapy.

Erlotinib (ERL) is a first-line targeted therapy for patients with epidermal growth factor receptor (EGFR)-mutant advanced non-small cell lung cancer (NSCLC). However, its effectiveness is hindered by acquired resistance and poor bioavailability. Carrier-free nanodrugs are a research hotspot due to their efficient targeting, high drug loading capacity, and the absence of any excipients.

Molecular characterization and function of sodium-dependent glucose transporter 1 in postprandial glucose homeostasis in Macrobrachium rosenbergii.

Aquatic animals often exhibit glucose intolerance following a glucose load, and understanding the mechanisms of glucose uptake is crucial for elucidating the underlying processes. Sodium-dependent glucose transporter 1 (SGLT1) plays a crucial role in the process of intestinal glucose absorption and transport in vertebrates, but there is limited information about its function in crustaceans. This study identified the SGLT1 gene (named MrSGLT1) from Macrobrachium rosenbergii.

Recent advance for enantiorecognition of chiral drugs sensing: Electrochemical, electrochemiluminescent and photoelectrochemical application.

Chiral isomers show different behaviours and properties in physiological activities. It is of great significance to find productive approach to realize the recognition of enantiomers, which is a key issue in biochemical and pharmaceutical fields. Nowadays, chiral identification can be successfully achieved according to the discrepancies of special signals correlated with different enantiomers of multiple electrode structures.

DAU-Net: a novel U-Net with dual attention for retinal vessel segmentation.

In fundus images, precisely segmenting retinal blood vessels is important for diagnosing eye-related conditions, such as diabetic retinopathy and hypertensive retinopathy or other eye-related disorders. In this work, we propose an enhanced U-shaped network with dual-attention, named DAU-Net, divided into encoder and decoder parts. Wherein, we replace the traditional convolutional layers with ConvNeXt Block and SnakeConv Block to strengthen its recognition ability for different forms of blood vessels while lightweight the model.

High paracrine activity of hADSCs cartilage microtissues inhibits extracellular matrix degradation and promotes cartilage regeneration.

Due to its unique structure, articular cartilage has limited self-repair capacity. Microtissues are tiny tissue clusters that can mimic the function of target organs or tissues. Using cells alone for microtissue construction often results in the formation of necrotic cores.

Global research trends on nanotechnology and colorectal cancer: a two-decade analysis.

Introduction: Colorectal cancer (CRC) remains a serious threat to humans worldwide. In this study, we used bibliometric analysis of the scientific literature to assess the trends and prospects of nanotechnology applications in CRC.

Materials And Methods: We used the Web of Science Core Collection database to screen relevant publications on nanotechnology and CRC from 2004 to 2023 based on the inclusion criteria.

Triple‑negative breast cancer cell‑derived piR‑31115 promotes the proliferation and migration of endothelial cells via METTL3‑mediated m6A modification of YAP1.

Triple‑negative breast cancer (TNBC), a highly malignant breast cancer subtype with a pronounced metastatic propensity, forms the focus of the present investigation. MDA‑MB‑231, a prevalently utilized TNBC cell line in cancer research, was employed. In accordance with the tumour angiogenesis theory, cancer cells are capable of instigating angiogenesis and the formation of a novel vascular system within the tumour microenvironment, which subsequently sustains malignant proliferation and metastasis.

Case report: Eczematous adverse drug reaction after selpercatinib treatment.

This study reports a 50-year-old patient presented with eczematous drug-eruption induced by selpercatinib after the treatment of non-small cell lung cancer (NSCLC). The patient has symmetric erythematous papules and plaques all over the body with dry, scaly skin accompanied by severe pruritus and visible scarring. After systemic treatment with glucocorticoids, the patient' skin lesions were reduced well.

Protective effect of sub-hypothermic mechanical perfusion combined with membrane lung oxygenation on a yorkshire model of brain injury after traumatic blood loss.

Purpose: To investigate the protective effect of sub-hypothermic mechanical perfusion combined with membrane lung oxygenation on ischemic hypoxic injury of yorkshire brain tissue caused by traumatic blood loss.

Methods: This article performed a random controlled trial. Brain tissue of 7 yorkshire was selected and divided into the sub-low temperature anterograde machine perfusion group (n = 4) and the blank control group (n = 3) using the random number table method.

Regulation of the phenolic release and conversion in oats (Avena sativa L.) by co-microbiological fermentation with Monascus anka, Saccharomyces cerevisiae and Bacillus subtilis.

Microbial fermentation is an effective method to improve the functional activity of oats (Avena sativa L.), while there are some limitations to the advantages of single microbial fermentation. In this study, a microbial co-culture fermentation system with Monascus anka, Saccharomyces cerevisiae and Bacillus subtilis to release and conversion oat phenolics was established.

Raman spectroscopy for cell analysis: Retrospect and prospect.

Cell analysis is crucial to contemporary biomedical research, as it plays a pivotal role in elucidating life processes and advancing disease diagnosis and treatment. Raman spectroscopy, harnessing distinctive molecular vibrational data, provides a non-destructive method for cell analysis. This review surveys the progress of Raman spectroscopy in cellular analysis, emphasizing its utility in identifying individual cells, monitoring biomolecules, and assessing intracellular environments.

Effects of Bacillus coagulans on kidney injury caused by Klebsiella pneumoniae in rabbits.

Klebsiella pneumoniae (KP) is a zoonotic conditionally pathogenic bacterium with a high prevalence of infection. It often induces purulent inflammation of the rabbit lungs, kidneys and other tissues, with high morbidity and mortality. Bacillus coagulans (BC) has the ability to regulate the balance of host intestinal flora and improve host immunity.

Inferiority feelings mediate the impact of subjective social support on anxiety/depression symptoms in individuals with physical disabilities.

Background: Persons with physical disabilities are more likely to suffer from psychological symptoms and inferiority feelings, and social support plays an important role in improving those symptoms. However, the interaction between psychological symptoms, inferiority feelings and social support is yet to be understood.

Methods: A cross-sectional study was conducted to investigate anxiety, depression, and inferiority feelings among individuals with physical disabilities in a Chinese sample.