SS18-SSX drives TYK2 expression to activate STAT3/Bcl2 axis, facilitating apoptosis evasion and advancing synovial sarcoma progression.

Synovial sarcoma (SS) is a rare soft tissue sarcoma characterized by high-grade malignancy and poor prognosis. Preliminary research indicates that apoptosis evasion is a key factor in SS progression, primarily attributed to the overexpression of anti-apoptotic genes. However, the mechanisms underlying this phenomenon are still not fully understood.

Micro-polluted water source purification of root channel wetland in Jiaxing, China.

Root channel wetlands, as a new type of nature-imitating wetland system, provide a paradigm for micro-polluted water source purification; however, there is a knowledge gap on root channel wetlands' pollution removal effects and their main influencing factors after longtime operation. This study collected the turbidity, ammonia nitrogen (NH-N), total nitrogen (TN), total phosphorus (TP), permanganate index (COD), dissolved oxygen (DO), and chemical oxygen demand (COD) at the inlet and outlet of Shijiuyang (SJY) wetland and Guanjinggang (GJG) wetland in Jiaxing City, China, from 2019 to 2021. The results showed that root channel wetlands had better water quality improvement effects.

CuO decorated TiCT MXene composites for non-enzymatic glucose sensing with large linear ranges.

TiCT MXene/CuO composites were prepared by acid etching combined with electrochemical technique. The abundant active sites on the surface of MXene greatly increase the loading of CuO nanoparticles, and the synergistic effect between the different components of the composite can accelerate the oxidation reaction of glucose. The results indicate that at the working potential of 0.

Deep insight on Li interlayer migration in O3-type NaLi1/3Mn2/3O2 as a cathode material for Na-ion batteries.

Layered manganese transition metal oxides, such as NaMnO2, have attracted great interest due to the low cost and high capacity. However, complex phase transitions in NaMnO2 lead to poor cycling stability. The introduction of Li doping has been confirmed to improve the performance of NaMnO2.

Clinical characteristics and lateralization of the horizontal semicircular canal light cupula.

Introduction: Positional vertigo and nystagmus are the main symptoms and signs of dizziness, respectively. Despite the clinical utility of the supine roll test (SRT) and null point (NP) in diagnosing light cupula, a type of positional vertigo, there exists a notable gap in the literature concerning the comprehensive evaluation of lateralization values based on various nystagmus characteristics and the intensity of direction-changing positional nystagmus (DCPN) in the SRT, particularly in comparison to the NP. Additionally, limited data on abnormal canal paresis (CP) in light cupula patients underscores the need for further research with a larger patient population to elucidate this mechanism.

Cadonilimab Combined with Chemotherapy with or without Bevacizumab as First-Line Treatment in Recurrent or Metastatic Cervical Cancer (COMPASSION-13): A Phase 2 Study.

Purpose: Immune checkpoint inhibitors (ICI) have been a potential treatment option for patients with cervical cancer in several clinical studies. We investigated the safety and efficacy of cadonilimab, a bispecific antibody targeting PD-1 and CTLA-4, plus standard therapy for the first-line treatment of R/M CC (recurrent and/or metastatic cervical cancer).

Patients And Methods: Eligible patients were assigned to 3 cohorts: cohort A-15 (cadonilimab 15 mg/kg every 3 weeks (Q3W) plus chemotherapy), cohort A-10 (cadonilimb 10 mg/kg Q3W plus chemotherapy), and cohort B-10 (cadonilimab 10 mg/kg Q3W plus chemotherapy and bevacizumab).

Salinity changes the nitrification activity and community composition of comammox in intertidal sediments of Yangtze River estuary.

The newly discovered complete ammonia-oxidizing (comammox) has been identified in different environments, including coastal environments, where salinity is one of the most important factors for the abundance and activity of nitrifiers. Here, we demonstrate the effect of salinity on comammox , canonical ammonia-oxidizing bacteria (AOB), and ammonia-oxidizing archaea (AOA) in the intertidal sediments of the Yangtze River estuary based on microcosm experiments, DNA stable-isotope probing (DNA-SIP), and potential ammonium-oxidation rate (PAR) tests for different groups of ammonia oxidizers with selective inhibitors. During microcosm incubations, the abundance of comammox was more sensitive to increased salinity than that of other ammonia oxidizers.

Structural, mechanical, and electronic properties of Ni-Co-based layered transition metal oxide LiNiCoO for Li-ion batteries from first principles.

The structural, mechanical, and electronic properties of Ni-Co-based layered transition oxide LiNiCoO (x = 0.1, 0.2, 0.

Genome-wide identification and functional analysis of long non-coding RNAs in reveal their potential roles in chlorantraniliprole resistance.

Long non-coding RNAs, referred to as lncRNAs, perform essential functions in some biological processes, including reproduction, metamorphosis, and other critical life functions. Yet, lncRNAs are poorly understood in pesticide resistance, and no reports to date have characterized which lncRNAs are associated with chlorantraniliprole resistance in . Here, RNA-seq was performed on two strains of exposed to chlorantraniliprole: one is a susceptible strain (S), and the other is a resistant strain (R).

The moderate substitution of returning for chemical fertilizer improves the N cycle function of key ecological bacterial clusters in soil.

(Chinese milk vetch) is a well-established resource of organic fertilizer widely used in paddy soil to partially replace chemical fertilizers. However, the influence of returning to fields on the soil bacterial community remains poorly understood. Here, we used different amounts of partially replacing chemical fertilizers and investigated the changes in soil physicochemical factors and the soil bacterial community structure responses.

Positive feedback between peanut and arbuscular mycorrhizal fungi with the application of hairy vetch in Ultisol.

Multiple agricultural practices are being applied to increase crop yield in order to overcome the food shortage. Green manure has emerged as an appropriate practice to improve soil fertility and crop yield. However, the potential functions of arbuscular mycorrhizal fungi (AMF) in the below-ground ecosystems following the application of green manure in Ultisols remain largely unexplored.

Research on the influence of role stressors on unsafe behavior among construction workers in China.

Individuals' unsafe behavior is identified as one of the important reasons leading to construction industry accidents. The purpose of the present study is to explore the mechanism of role stressors' impact on unsafe behavior, the mediating role of psychological strain and the moderating role of empowering leadership among construction workers. The sample used for the analyses in this study includes 600 employees from 10 different construction companies in China.

Work-family conflict, work engagement and unsafe behavior among miners in China.

The present study aims to explore the relationship between work-family conflict and unsafe behavior among underground coal miners, testing the mediating role of work engagement in this relationship. A cross-sectional survey was conducted in Shanxi Province, China from June to August 2020. A total of 580 front-line miners were recruited for this study.

Enhanced performance of p-type SnOthin film transistors through defect compensation.

Due to the unique outermost orbitals of Sn, hole carriers in tin monoxide (SnO) possess small effective mass and high mobility among oxide semiconductors, making it a promising p-channel material for thin film field-effect transistors (TFTs). However, the Sn vacancy induced field-effect mobility deterioration and threshold voltage () shift in experiments greatly limit its application in complementary metal-oxide-semiconductor (CMOS) transistors. In this study, the internal mechanism of vacancy defect compensation by aluminum (Al) doping in SnOfilm is studied combining experiments with the density functional theory (DFT).

Efficient Energy-Transfer-Induced High Photoelectric Conversion in a Dye-Encapsulated Ionic Pyrene-Based Metal-Organic Framework.

The relationship between the aggregation states of pyrene-based linkers and the photoluminescence/photoelectric performance was well studied by the formation of an anionic metal-organic framework, [BMI][Mg(TBAPy)(HO)]·2dioxane, which shows highly enhanced light-harvesting and photoelectric conversion efficiency by the encapsulation of D-π-A cation dyes.

Interactions between gastric microbiota and metabolites in gastric cancer.

The development and progression of gastric cancer (GC) is greatly influenced by gastric microbiota and their metabolites. Here, we characterized the gastric microbiome and metabolome profiles of 37 GC tumor tissues and matched non-tumor tissues using 16s rRNA gene sequencing and ultrahigh performance liquid chromatography tandem mass spectrometry, respectively. Microbial diversity and richness were higher in GC tumor tissues than in non-tumor tissues.

Two-photon fluorogenic probe for visualizing PGP-1 activity in inflammatory tissues and serum from patients.

A PGP-1-specific one/two-photon fluorogenic probe (BH1), capable of high sensitivity, super selectivity, and visual imaging of endogenous PGP-1 activity from live mammalian cells and serum/skin tissues from patients by using one/two-photon fluorescence microscopy (O/TPFM).

Room-Temperature Phosphorescent Co-Crystal Showing Direct White Light and Photo-Electric Conversion.

The development of molecular crystalline materials with efficient room-temperature phosphorescence has been obtained much attention due to their fascinating photophysical properties and potential applications in the fields of data storage, bioimaging and photodynamic therapy. Herein, a new co-crystal complex [(DCPA) (AD)] (DCPA = 9,10-di (4-carboxyphenyl)anthracene; AD = acridine) has been synthesized by a facile solvothermal process. Crystal structure analysis reveals that the co-crystal possesses orderly and alternant arrangement of DCPA donors and AD acceptors at molecular level.

High Transient-Thermal-Shock Resistant Nanochannel Tungsten Films.

Developing high-performance tungsten plasma-facing materials for fusion reactors is an urgent task. In this paper, novel nanochannel structural W films prepared by magnetron sputtering deposition were irradiated using a high-power pulsed electron beam or ion beam to study their edge-localized modes, such as transient thermal shock resistance. Under electron beam irradiation, a 1 μm thick nanochannel W film with 150 watt power showed a higher absorbed power density related cracking threshold (0.

Coexistent Integer Charge Transfer and Charge Transfer Complex in F4-TCNQ-Doped PTAA for Efficient Flexible Organic Light-Emitting Diodes.

Understanding the mechanism of interaction between organic polymers and dopants is of great significance to further enhance the performances of flexible electronics. Here, the two doping mechanisms of charge transfer complex (CTC) and integer charge transfer (ICT) are found to coexist in p-π conjugated PTAA doped with the strong acceptor F4-TCNQ, and their correlation is affected by the HJ-aggregate state of the doped polymer. The growth of the J-aggregate caused by the increase of CTC would lead to a corresponding formation of ICT.

Angle-Dependent Polarized Emission and Photoelectron Performance of Dye-Encapsulated Metal-Organic Framework.

Molecule-based crystalline materials with angle-dependent polarized emission have attracted considerable attention owing to their extensive applications in displays and anticounterfeiting. Herein, one anionic metal-organic framework (MOF) {[Zn(μ-OH)(NDC)(HNDC)](HPIM)} was constructed on the basis of an excellent photoactive ligand naphthalene-1,4-dicarboxylic acid (HNDC). The protonated 2-propylimidazole (HPIM) guests residing in the nanochannels of MOF can be exchanged by a D-π-A cationic dye.

The complete genome of extracellular protease-producing Deinococcus sp. D7000 isolated from the hadal region of Mariana Trench Challenger Deep.

The general features and genomic characteristics of gram-positive Deinococcus sp. D7000 isolated from the hadal region of Mariana Trench Challenger Deep were analyzed in this study. Deinococcus sp.

CrI/YCH Heterointerface-Induced Stable Half-Metallicity of Two-Dimensional CrI Monolayer Ferromagnets.

Two-dimensional (2D) CrI monolayer ferromagnets are key to the development of future miniature spintronic devices and modulating them into a half-metal will greatly expand the application scenarios of CrI in nanospintronics. Nevertheless, existing strategies to induce half-metallicity of a CrI monolayer remain experimentally challenging and have unstable issues. In this work, the introduction of a 2D electride [YC]·2e as an auxiliary layer is shown to be an effective way to achieve the generation of stable half-metallicity in the CrI monolayer.