Expanding horizons in theragnostics: from oncology to multidisciplinary applications.

Theragnostics is the integration of treatment and diagnosis, involving a drug or technology that combines diagnostic imaging with targeted therapy. This approach utilizes imaging to identify specific biological targets, which are then used to deliver therapeutic effects for the benefit of patients. The effectiveness and potential of theragnostics in improving patient outcomes are supported by significant clinical trials and technological innovations.

Family history and genetic risk score combined to guide cancer risk stratification: A prospective cohort study.

Family history (FH) of cancer and polygenic risk scores (PRS) are pivotal for cancer risk assessment, yet their combined impact remains unclear. Participants in the UK Biobank (UKB) were recruited between 2006 and 2010, with complete follow-up data updated until February 2020 for Scotland and January 2021 for England and Wales. Using UKB data (N = 442,399), we constructed PRS and incidence-weighted overall cancer PRS (CPRS).

Effect of copper and temperature on the photosynthetic physiological characteristics of Ulva linza under elevated CO concentrations.

Copper (Cu) is vital for macroalgae's functions, but high concentrations can be toxic. Rising CO levels affect algal growth and Cu bioavailability. In this study, the results reveal that at 5 °C, low Cu increased Ulva linza growth, while high Cu and elevated CO decreased growth.

Ocean acidification may alleviate the toxicity of zinc to the macroalga, Ulva lactuca.

We investigated the toxic effects of different zinc (Zn) concentrations (natural seawater, 25 μg/L, and 100 μg/L) under two CO concentrations (410 ppmv, and 1000 ppmv) on Ulva lactuca. A significant decrease in the relative growth rate of U. lactuca was observed with an increase in Zn concentration under the low CO treatment condition, and we observed a notable decrease at 100 μg/L Zn under the high CO treatment condition.

Large and non-spherical seeds are less likely to form a persistent soil seed bank.

There is some evidence that seed traits can affect the long-term persistence of seeds in the soil. However, findings on this topic have differed between systems. Here, we brought together a worldwide database of seed persistence data for 1474 species to test the generality of seed mass-shape-persistence relationships.

The accumulation of cadmium and lead in wheat grains is primarily determined by the soil-reducible cadmium level during wheat tillering.

The significant increase in cadmium (Cd) and lead (Pb) pollution in agricultural soil has greatly heightened environmental contamination issues and the risk of human diseases. However, the mechanisms underlying the transformation of Cd and Pb in soil as well as the influencing factors during their accumulation in crop grains remain unclear. Based on the analysis of the distribution trend of Cd and Pb in soil during the growth and development stages of wheat (tillering, filling, and maturity) in alkaline heavy metal-polluted farmland in northern China, this study investigated the response mechanism of soil heavy metal form transformation to soil physicochemical properties, and elucidated the main determining periods and influencing factors for Cd and Pb enrichment in wheat grains.

Surface Engineering on Zinc Anode for Aqueous Zinc Metal Batteries.

Rechargeable aqueous zinc metal batteries (AZMBs) are considered as a potential alternative to lithium-ion batteries due to their low cost, high safety, and environmental friendliness. However, the Zn anodes in AZMBs face severe challenges, such as dendrite growth, metal corrosion, and hydrogen evolution, all of which are closely related to the Zn/electrolyte interface. This article offers a short review on surface passivation to alleviate the issues on the Zn anodes.

Right-sided infective endocarditis or thrombus? Report of two cases diagnosed by transthoracic echocardiography.

Background: Right-sided infective endocarditis (RSIE) is a relatively uncommon condition which is difficult to distinguish from thrombus, particularly when the site of infection or the patient's symptoms are atypical. There have been few reports exploring the differential diagnostic and analytical features between RSIE and thrombus.

Case Presentation: Here, we presented two cases of RSIE-one involving the tricuspid valve and the other affecting the pulmonary artery.

The association between METS-IR, an indirect index for insulin resistance, and lung cancer risk.

Background: Insulin resistance has been reported to increase the risk of breast, prostate and colorectal cancer. However, the role of insulin resistance and its interaction with genetic risk in the development of lung cancer remains controversial. Therefore, we aimed to explore the association between a novel metabolic score for insulin resistance (METS-IR) and lung cancer risk.

Zn(002)-preferred and pH-buffering triethanolamine as electrolyte additive for dendrite-free Zn anodes.

Zn anodes of aqueous batteries face severe challenges from side reactions and dendrite growth. Here, triethanolamine (TEOA) is developed as an electrolyte additive to address these challenges. It enhances the exposure of Zn(002) and diminishes the change in pH.

Does digital economy development matter? Role of supply chain management and CO emissions in BRICS.

Large risks and opportunities arise for production operations as a result of international governmental initiatives to limit carbon emissions. In instance, high-emitting manufacturing processes may be a reflection of productive inefficiencies and the uncertainty of the prices of carbon dioxide emissions. Recently, there has been a lot of attention paid to the topic of ecologically responsible supply chain management.

[Pharmacokinetics and tissue distribution of four alkaloids in Ermiao Pills and Sanmiao Pills in normal and arthritic model rats].

This work aimed to investigate the differences of pharmacokinetics and tissue distribution of four alkaloids in Ermiao Pills and Sanmiao Pills in normal and arthritic model rats. The rat model of arthritis was established by injecting Freund's complete adjuvant, and ultra-high performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) in the positive ion multiple reaction monitoring(MRM) mode was used for the determination of four alkaloids in plasma and tissues of normal and arthritic rats after administration of Ermiao Pills and Sanmiao Pills, respectively. The differences in pharmacokinetics and tissue distribution of the four active components were compared, and the effect of Achyranthis Bidentatae Radix on the major components of Sanmiao Pills was explored.

Association between the prognostic nutritional index and severe headache or migraine: a population-based study.

Purpose: Migraine is a highly prevalent headache disorder, and intake of various nutrients and special diets may improve migraine symptoms. We aimed to clarify the association between nutritional status and migraine.

Patients And Methods: We collected the data of 1838/8953 (migraineurs/all participants) from the National Health and Nutrition Examination Survey (NHANES) 1999-2004 cycle.

Resilient Public Transport Construction in Mega Cities from the Perspective of Ecological Environment Governance.

With the rapid development of the social economy, environmental and resource constraints of economic growth are becoming more and more serious. Therefore, for cities, we should take the road of green development and sustainable development. On the one hand, we should fully implement the basic policies issued by the central government.

Evodiamine decreased the systemic exposure of pravastatin in non-alcoholic steatohepatitis rats due to the up-regulation of hepatic OATPs.

Context: Patients with non-alcoholic steatohepatitis (NASH) may have a simultaneous intake of pravastatin and evodiamine-containing herbs.

Objective: The effect of evodiamine on the pharmacokinetics of pravastatin and its potential mechanisms were investigated in NASH rats.

Materials And Methods: The NASH model was conducted with feeding a methionine choline-deficient (MCD) diet for 8 weeks.

Gestational exposure to acrylamide suppresses luteal endocrine function through dysregulation of ovarian angiogenesis, oxidative stress and apoptosis in mice.

The discovery of acrylamide in various carbohydrate-rich foods cooked at high temperatures has attracted public health concerns. This study aimed to elucidate the effects and mechanisms additional with acrylamide exposure on the luteal function in vivo during early- and mid-pregnancy. Mice were fed with different dosages of acrylamide (0, 10 and 50 mg/kg/day) by gavage from gestational days (GD) 3 to GD 8 or GD 13.

Development and external validation of a nomogram for neurosyphilis diagnosis among non-HIV patients: a cross-sectional study.

Background: The diagnosis of neurosyphilis is challenging due to the requirement of a lumbar puncture and cerebrospinal fluid (CSF) laboratory tests. Therefore, a convenient diagnostic nomogram for neurosyphilis is warranted. This study aimed to construct diagnostic models for diagnosing neurosyphilis.

Association Between Serum Lipid Levels and Severe Headache or Migraine in Representative American Population: A Cross-sectional Study.

Background: The relationship between serum lipids and migraine remains controversial.

Objective: This study aimed to analyze the association between serum lipids and severe headache or migraine in the general population.

Methods: Data were collected from a nationally representative sample of participants in the National Health and Nutrition Examination Survey from 1999 to 2004.

The impact of COVID-19 pandemic on headache symptoms and drug withdrawal among patients with medication overuse headache: a cross-sectional study.

Background: Coronavirus disease 2019 (COVID-19) bring about a range of psychological distress and symptom deterioration to headache patients especially to some migraineurs. Compared to migraineurs or normal control, medication overuse headache (MOH) patients are more likely to experience a worse psychological distress and poorer outcome in non-COVID-19 time. However, in COVID-19 pandemic, whether MOH patients would have greater physical and mental symptom deterioration or worse relief of headache symptoms and medications overuse remained unclear.

Rutaecarpine enhances the anti-diabetic activity and hepatic distribution of metformin via up-regulation of Oct1 in diabetic rats.

Diabetes mellitus is a chronic metabolic disorder with multiple complications, patients who receive metformin may have a simultaneous intake of herbal medicine containing rutaecarpine due to cardiovascular protection and hypolipidemic effects of rutaecarpine. There might be drug interactions between metformin and rutaecarpine. This study aimed to investigate the effects of rutaecarpine on the pharmacodynamics and pharmacokinetics of metformin in diabetic rats.

Impact of Headache Frequency and Sleep on Migraine Patients During the COVID-19 Pandemic.

Background: Coronavirus disease 2019 (COVID-19) has spread worldwide and poses a great threat to global health. COVID-19 has also an unneglected effect on migraine patients. Migraine attack frequency is one of the migraine characteristics, and its impact during COVID-19 needs further research.

Suppression of store-operated Ca entry regulated by silencing Orai1 inhibits C6 glioma cell motility via decreasing Pyk2 activity and promoting focal adhesion.

Store-operated Ca entry (SOCE) plays an important role in regulating Ca influx, which participates in tumor cell survival and motility. We aim to elucidate the role of SOCE in the behavior of C6 glioma cells. Lentiviral vector inserted with the Orai1-targeting shRNA was used to inhibit SOCE in C6 glioma cells.