Publications by authors named "Wenjin Liu"

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause repeated infections. China experienced an outbreak of COVID-19 (coronavirus disease 2019) after the Chinese government changed its COVID-19 policy in December 2022. However, little is known about the influencing factors, such as a history of previous infection and vaccine dose, and whether these factors affect the time at which the antigen test results become negative for SARS-CoV-2.

View Article and Find Full Text PDF

The tiled fiber laser array is a promising architecture for power scaling and mitigation of atmospheric turbulence. Precise tip-tilt detection and steering of the beamlets in the array to guarantee effective overlap in the far-field is essential for high beam qualities. However, the beamlets are tightly coupled in the far-field, making it a major challenge to identify each other.

View Article and Find Full Text PDF

Mechanoluminescence (ML)-based sensors are emerging as promising wearable devices, attracting attention for their self-powered visualization of mechanical stimuli. However, challenges such as weak brightness, high activation threshold, and intermittent signal output have hindered their development. Here, a mechanoluminescent/electric dual-mode strain sensor is presented that offers enhanced ML sensing and reliable electrical sensing simultaneously.

View Article and Find Full Text PDF

Hu antigen R (HuR) plays a key role in regulating genes critical to the pathogenesis of diabetic nephropathy (DN). This study investigates the therapeutic potential of niclosamide (NCS) as an HuR inhibitor in DN. Uninephrectomized mice were assigned to four groups: normal control; untreated db/db mice terminated at 14 and 22 weeks, respectively; and db/db mice treated with NCS (20 mg/kg daily via i.

View Article and Find Full Text PDF

Duck-derived lactic acid bacteria (DDL) are a crucial beneficial bacterium in the intestines, contributing significantly to the health of ducks. However, the mechanism by which these DDL improves the growth performance and meat quality of Muscovy duck is not clear. In this study, A total of 800 male Muscovy ducks, initially weighing 50.

View Article and Find Full Text PDF

P2Y receptor (P2YR) is activated by uridine 5'-diphosphate-glucose, which is involved in many human inflammatory diseases. Based on the molecular docking analysis of currently reported P2YR antagonists and the crystallographic overlap study between the reported P2YR antagonist compounds and , a series of N-substituted-acetamide derivatives were designed, synthesized, and identified as novel and potent P2YR antagonists. The most potent antagonist, compound (-(1-benzo[]imidazol-6-yl)-2-(4-bromophenoxy)acetamide, IC = 0.

View Article and Find Full Text PDF

Dietary absorption and digestion are influenced by the microbiota, morphology, and digestive enzymes of intestines, and fermentation is a popular and effective technique to enhance animal rearing growth performance. This study aims to explore the pivotal role of Muscovy duck probiotics fermented feedstuff (FF) in altering the growth performance by reshaping gut morphology, microorganisms and metabolism. The findings showed that FF considerably raised the levels of fatty acids (FA) and small peptides (7-19AA) in the diet.

View Article and Find Full Text PDF

Background: The P2X7 receptor (P2X7R) is known to play a significant role in regulating various pathological processes associated with immune regulation, neuroprotection, and inflammatory responses. It has emerged as a potential target for the treatment of diseases. In addition to chemically synthesized small molecule compounds, natural products have gained attention as an important source for discovering compounds that act on the P2X7R.

View Article and Find Full Text PDF

The degradation of lignin-carbohydrate complex (LCC) esters has been proven to be crucial for the selective separation of lignocellulosic components. This study utilized Raman microspectroscopy to image the preferential degradation of lignin and LCC esters from the bamboo wall during successive NaOH (0.2 to 5.

View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on microsatellite instability-high (MSI-H) in cholangiocarcinoma (CCA), investigating its implications for genomic features and immunotherapy outcomes.
  • It analyzed tumor samples from 887 CCA patients and found that MSI-H status was linked to significant genetic mutations and higher tumor mutation burden (TMB) compared to microsatellite stable (MSS) status.
  • Patients with MSI-H who received PD-1 inhibitor therapy experienced better overall survival and progression-free survival, indicating that MSI-H status and PD-L1 positivity could enhance immunotherapy effectiveness.
View Article and Find Full Text PDF

Background: Hypertension-induced impairment of the cerebral artery network contributes to cognitive impairment. Characterizing the structure and function of cerebral arteries may facilitate the understanding of hypertension-related pathological mechanisms and lead to the development of new indicators for cognitive impairment.

Purpose: To investigate the associations between morphological features of the intracranial arteries distal to the circle of Willis on time-of-flight MRA (TOF-MRA) and cognitive performance in a hypertensive cohort.

View Article and Find Full Text PDF

The extensive consumption of fossil fuels increases CO concentration in the atmosphere, resulting in serious global warming problems. Meanwhile, the problem of water contamination by organic substances is another significant global challenge. We have successfully synthesized ZnGaTe/g-CN (ZGT/GCN) composites for the first time as effective photocatalysts for both pollutant degradation and CO reduction.

View Article and Find Full Text PDF

The interaction of MPs and aromatic hydrocarbons in seawater and pure water was examined using experimental measurements, molecular dynamics (MD) simulations, and density functional theory (DFT) calculations in light of the potential health risks posed by microplastic (MPs)-associated aromatic hydrocarbon pollutants. Isothermal studies and MD simulations suggested that MPs have a stronger affinity for aromatic hydrocarbons in seawater. To uncover the mechanism, MPs' surface characteristics and their intermolecular interactions with aromatic hydrocarbons were examined.

View Article and Find Full Text PDF

Pesticides are extensively used in agricultural production, and their residues in soil, water, and agricultural products have become a threat to aquatic ecosystem. In this study, the toxicity of haloxyfop-p-methyl, an aryloxyphenoxypropionate herbicide was studied using the model animal zebrafish. The development of zebrafish larvae was affected by haloxyfop-p-methyl including spinal deformities, decreased body length, slow heart rate, and large yolk sac area.

View Article and Find Full Text PDF

In this paper, silver niobate (AgNbO) material was synthesized by a solid-state reaction. AgNbO was characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), UV-visible diffuse reflectance spectroscopy (DRS), and Brunauer-Emmett-Teller (BET) measurement. The photocatalytic activity of AgNbO was investigated in degradation of sulfamethoxazole (SMX) under visible light, which is a widely used antibiotic with significant threats towards health and aquatic organisms.

View Article and Find Full Text PDF
Article Synopsis
  • The study analyzes tumor genomes from over 10,000 cancer patients in China using advanced DNA sequencing technology to identify actionable genomic alterations.
  • It compares genetic changes and tumor characteristics between Chinese and American patient populations, highlighting both similarities and differences.
  • The research reveals that 64% of Chinese patients have clinically actionable genomic alterations, which could influence treatment decisions for targeted therapy and immunotherapy, aiding in personalized medicine approaches.
View Article and Find Full Text PDF

Basal-like breast cancer (BLBC) accounts for approximately 15% of all breast cancer cases, and patients with BLBC have a low survival rate. Our previous study demonstrated that the KLF5 transcription factor promotes BLBC cell proliferation and tumor growth. In this study, we demonstrated that the histone deacetylase inhibitors (HDACi), suberoylanilide hydroxamic acid (SAHA), and trichostatin A (TSA), increased KLF5 acetylation at lysine 369 (K369), downregulated KLF5 protein expression levels, and decreased cell viability in BLBC cell lines.

View Article and Find Full Text PDF

Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the Transwell cell migration assay data shown in Fig. 5A were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to , the Editor has decided that this paper should be retracted from the Journal.

View Article and Find Full Text PDF

Although chlorobromoisocyanuric acid has been widely used in agriculture, its deleterious toxicity on aquatic organisms remains rare. In this study, zebrafish were exposed to chlorobromoisocyanuric acid (0, 30, 40, and 50 mg/L) from 10 to 96 h post-fertilization (hpf). We found a significant reduction in immune cell numbers (neutrophils and macrophages) and the area of thymus at 96 hpf.

View Article and Find Full Text PDF

The van der Waals (vdW) heterostructures formed by stacking layered two-dimensional materials can improve the performance of materials and provide more applications. In our paper, six configurations of AlN/MoSvdW heterostructures were constructed, the most stable structure was obtained by calculating the binding energy. On this basis, the effect of external vertical strain on AlN/MoSheterostructure was analyzed, the calculated results show that the optimal interlayer distance was 3.

View Article and Find Full Text PDF

Introduction: C-X-C motif chemokine ligand 16 (CXCL16) is an inflammatory marker that has been found to be predictive of outcomes in patients with cardiovascular disease. Our previous work has also demonstrated its relation to cardiac injury in dialysis patients. However, it is yet unclear whether there is an association between CXCL16 and adverse outcomes in dialysis patients.

View Article and Find Full Text PDF

Objective: Studies in the general population suggest that central blood pressure (BP) may be superior to peripheral BP in risk assessment. Although ambulatory brachial BP is recognized as the most reliable BP measurement in the dialysis population, there is no comparison of office central BP with ambulatory BP regarding risk stratification in these patients.

Methods: In a multicenter prospective study of dialysis patients, central BP was measured noninvasively on a midweek nondialysis day, with interdialytic ambulatory BP and predialysis BP also collected.

View Article and Find Full Text PDF

Purpose: Dietary sodium and potassium intake are associated with stroke, but the potential mechanisms are unclear. We aimed to study the association between sodium and potassium intake and subclinical cerebrovascular health in hypertensive older males using multimodal magnetic resonance imaging.

Methods: A total of 189 hypertensive male subjects without previous cardiovascular or cerebrovascular disease were included.

View Article and Find Full Text PDF
Article Synopsis
  • - The study investigated the toxic effects of the herbicide sulfometuron methyl (SM) on zebrafish, revealing that exposure to increasing concentrations (10, 20, and 40 mg/L) led to higher mortality and lower hatching rates in the embryos.
  • - Immune cell counts decreased in a dose-dependent manner, with significant alterations in inflammatory responses and a reduction in anti-inflammatory factors observed, particularly at the highest concentration of SM.
  • - Behavioral tests indicated that SM exposure increased overall activity in larval zebrafish, while biochemical assessments showed heightened oxidative stress and increased apoptosis markers, emphasizing the harmful impacts of SM on development and biological functions in aquatic organisms.
View Article and Find Full Text PDF

Background An artificial intelligence vessel segmentation tool, Fully Automated and Robust Analysis Technique for Popliteal Artery Evaluation (FRAPPE), was used to analyze a large databank of popliteal arteries imaged through the OAI (Osteoarthritis Initiative) to study the impact of atherosclerosis risk factors on vessel dimensions and characterize remodeling patterns. Methods and Results Magnetic resonance images from 4668 subjects contributing 9189 popliteal arteries were analyzed using FRAPPE. Age ranged from 45 to 79 years (median, 61), and 58% were women.

View Article and Find Full Text PDF