Publications by authors named "Wenjin Guo"

Skeletal muscle is an essential tissue for maintaining the body's basic functions. The basic structural unit of skeletal muscle is the muscle fiber, and its type is the main factor that determines the athletic ability of animals. The O-linked N-acetylglucosamine (O-GlcNAc) modification, a reversible protein post-translational modification, is involved in many important biological processes such as gene transcription, signal transduction, cell growth, and differentiation.

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Nonalcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases. O-Linked attachment of beta-N-acetylglucosamine (O-GlcNAc) are ubiquitous post-translational modifications of proteins as "nutrient sensors" and "stress receptors" in the body that are involved in maintaining normal cellular physiological functions. Increased levels of O-GlcNAcylation have been found in the liver samples of patients with NAFLD and nonalcoholic steatohepatitis.

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Mastitis in dairy cows is an inflammatory disease that severely affects the health and lactation functions of dairy cows. Mitochondrial damage is closely related to the inflammatory response. How to effectively alleviate mitochondrial damage is the key to preventing and treating mastitis in dairy cows.

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Background: Dairy mastitis, a prevalent condition affecting dairy cattle, represents a significant challenge to both animal welfare and the quality of dairy products. However, current treatment options remain limited. Stigmasterol (ST) is a bioactive component of Prunella vulgaris L.

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Staphylococcus aureus (S. aureus) is a major zoonotic pathogen, with mammary gland infections contributing to mastitis, a condition that poses significant health risks to lactating women and adversely affects the dairy industry. Therefore, understanding the immune mechanisms underlying mammary infections caused by S.

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This study investigated the effects of formulation and ultrasound on the processing properties and nutrient digestion of soy protein isolate (SPI)-egg white protein (EWP) emulsion gels. The incorporation of EWP significantly improved the texture properties and freeze-thaw stability through disulfide bonds and homogeneous networks in comparison to SPI emulsion gels. However, swelling ratio of emulsion gels at SPI:EWP ratios of 3:1 and 2:1 decreased due to disruption of SPI network continuity.

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Polysaccharides, key bioactive compounds derived from Chinese herbs, are increasingly recognized for their therapeutic potential in modulating gut microbiota to treat various diseases. However, their efficacy in alleviating mammary inflammation and oxidative stress and protecting the blood-milk barrier (BMB) compromised by Staphylococcus aureus (S. au) infection remains uncertain.

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The "gut-brain axis" is involved in many physiological processes. However, its role in regulating mammary gland (MG) development remains unknown. In this study, we established the mice model of bilateral subdiaphragmatic vagotomy (Vago) to clarify the effects of "gut-brain axis" on MG development in pubertal mice.

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Article Synopsis
  • - Recent research shows that polysaccharides can improve intestinal health, which in turn helps reduce disease progression, specifically in mastitis cases in mice.
  • - Administering a specific polysaccharide (ASP) lowered inflammation and damage caused by mastitis, but these benefits disappeared when antibiotics were used, highlighting the importance of gut microbiota.
  • - The study found that ASP boosts microbial diversity and shifts gut bacteria composition, increasing helpful metabolites while decreasing harmful ones, suggesting potential new treatment strategies for mastitis and other infections.
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  • - Recent research on visual working memory (VWM) shows there’s a hierarchy of memory storage, where less relevant memories can shift to a passive state, allowing current memories to be actively manipulated.
  • - Stimulating this passive memory can reactivate it, potentially causing interference with active memory; hence, to maintain stability, passive memory may require suppression during active tasks.
  • - Experiments measuring brain activity while participants performed memory tasks indicated that while passive memories are maintained, there is a neural suppression of these memories that remains unaffected by the load of active memory tasks.
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  • - Elastocaloric cooling is a solid-state technology aimed at enhancing cooling efficiency while reducing energy consumption, addressing global warming and energy shortages.
  • - A new heat pump design using fiber twisting and periodic non-linear stress improves cooling performance, achieving a high coefficient of performance (COP of 30.8) and low hysteresis work.
  • - This innovative design significantly extends the device's cycle life to 14,752 cycles and delivers effective cooling with a temperature span of 25.6 K and a specific cooling power of 1850 W/kg.
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: An adequate supply of energy is essential for the proper functioning of all life activities in living organisms. As organelles that store neutral lipids, lipid droplets (LDs) are involved in the synthesis and metabolism of lipids in cells and are also an important source of energy supply. : A comprehensive summary of the literature was first carried out to screen for relevant proteins affecting the morphological size of LDs.

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The development of functional surgical sutures with excellent mechanical properties, good fluorescence, and high cytocompatibility is highly required in the field of medical surgeries. Achieving fibers that simultaneously exhibit high mechanical robustness, good spinnability, and durable fluorescence emission has remained challenging up to now. Taking inspiration from the spinning process of spider silk and the luminescence mechanism of jellyfish, this work reports a luminous artificial spider silk prepared with the aim of balancing the fiber spinnability and mechanical robustness.

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Selective CO photoreduction to C hydrocarbons is significant but limited by the inadequate adsorption strength of the reaction intermediates and low efficiency of proton transfer. Herein, an ameliorative *CO adsorption and HO activation strategy is realized via decorating bismuth oxychloride (BiOCl) nanostructures with different metal (Pt, Pd, and Au) species. Experimental and theoretical calculation results reveal that distinct *CO binding energies and *H acquisition abilities of the metal cocatalysts mediate the CO reduction activity and hydrocarbon selectivity.

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Stigmasterol (ST), a phytosterol found in food, has various biological activities. However, the effect of ST on milk synthesis in dairy cows remains unclear. Therefore, bovine primary mammary epithelial cells (BMECs) were isolated, cultured, and treated with ST to determine the effect of ST on milk synthesis.

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High-yield dairy cows typically undergo intense cellular metabolism, leading to oxidative stress in their mammary tissues. Our study found that compared with ordinary cows, these high-yield cows had significantly elevated levels of HO, lipoperoxidase, and total antioxidant capacity in their blood. This increased oxidative stress is associated with heightened expression of genes such as GCLC, GCLM, and SIRT1 and proteins such as SIRT1 in the mammary tissue of high-yield cows.

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Article Synopsis
  • Mammary gland aging is a big problem for both humans and animals, and finding ways to slow it down is very important.
  • Puerarin, a natural substance from a plant called Pueraria lobata, has health benefits like reducing inflammation and fighting damage in cells.
  • Research shows that puerarin can help slow down mammary gland aging in mice by affecting certain pathways in the body and working with helpful bacteria in their guts.
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Background: Cold as a common environmental stress, causes increased heat production, accelerated metabolism and even affects its production performance. How to improve the adaptability of the animal organism to cold has been an urgent problem. As a key hub of lipid metabolism, the liver can regulate lipid metabolism to maintain energy balance, and O-GlcNAcylation is a kind of important PTMs, which participates in a variety of signaling and mechanism regulation, and at the same time, is very sensitive to changes in stress and nutritional levels, and is the body's "stress receptors" and "nutrient receptors".

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  • Intermetallic compounds (IMCs) are valuable in catalysis due to their fixed composition and ordered structure, but forming them with controlled metal occupancy has been challenging.
  • This study introduces a new solvothermal method to synthesize various Bi-Pd IMCs and explores their properties using electrocatalytic CO reduction.
  • The findings show that different atomic arrangements in these IMCs lead to varied surface affinities for key reaction intermediates, resulting in selective production of formate, CO, and hydrogen, thereby enhancing understanding of structure-performance relationships in catalysis.
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Ghrelin regulates diverse physiological activities. However, the effects of this hormone on the milk fat synthesis remain unknown. This study aimed to investigate the effect of acylated ghrelin (AG) on milk fat synthesis by modifying the expression (knockdown or overexpression) of growth hormone secretagogue receptor 1a (GHSR1a) and Th-inducing POK (ThPOK) in primary bovine mammary epithelial cells (BMECs).

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Valine, a branched-chain amino acid found in dairy cows, has been recognized for its critical role in milk synthesis. However, the precise effect of valine on lactation in dairy cows remains an area of investigation. In our study, bovine mammary epithelial cells (BMECs) were isolated to explore the mechanism through which valine enhances milk synthesis.

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  • There is a growing need for efficient solid-state cooling technologies and materials that can withstand many cycles of use.
  • This study introduces the use of poly-p-phenylene benzodioxole (PBO) fibers for elasto- and twistocaloric cooling methods, achieving impressive temperature drops of -0.4 K and -1.3 K through stretching and twisting, respectively.
  • The PBO fibers demonstrate a significant cooling effect of -3.7 K at 35% strain and an outstanding cycle life of 200,000 cycles, along with a strain-sensitive color change feature when coated with liquid crystallite dyes.
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In recent years, the development of electrochemical biosensors for uric acid has made great achievements. Firstly, uric acid electrochemical biosensors were classified according to their reaction mechanism. Then, the reaction mechanism of the uric acid sensor and the application of nano-modified materials were deeply analyzed from the perspective of non-enzyme and enzymes.

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The axial orientation of molecular chains always results in an increase in fiber strength and a decrease in toughness. Here, taking inspiration from the skin structure, artificial spider silk with a buckled sheath-core structure is developed, with mechanical strength and toughness reaching 1.61 GPa and 466 MJ m , respectively, exceeding those of Caerostris darwini silk.

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