Publications by authors named "Wenjin Bian"
Article Synopsis
- Pruritus, particularly chronic post-burn pruritus (CPBP), is an itch that lasts for over six weeks due to skin damage and abnormal healing, with unknown brain mechanisms contributing to the condition.
- A study involving 20 CPBP patients and 20 healthy controls used resting-state fMRI to analyze brain activity through various measures while accounting for factors like age.
- Results indicated significant brain activity differences in CPBP patients, including higher regional homogeneity (ReHo) in various areas such as the middle frontal gyrus, and increased amplitude of low-frequency fluctuations (ALFF), suggesting altered brain function related to ongoing itch sensation.
Article Synopsis
- The study investigates the effectiveness of SyMRI-derived parameters from lumbar marrow in predicting treatment response and improving risk stratification for multiple myeloma patients.
- Fifty-nine newly diagnosed participants were analyzed, revealing that T1 and T2 values from SyMRI are independent predictors of treatment response, with specific cut-off values identified for R-ISS staging.
- The findings suggest that synthetic MRI could be a valuable tool for early treatment response prediction and enhancing risk stratification in multiple myeloma patients.
The aim of the study was to develop a new whole spinal MRI-based tumor burden scoring method in participants with newly diagnosed multiple myeloma (MM) and to explore its prognostic significance. We prospectively recruited participants with newly diagnosed MM; performed whole spinal MRI (sagittal FSE TWI, sagittal IDEAL TWI, and axial FLAIR TWI) on them; and collected their clinical data, early treatment response, progression-free survival (PFS), and overall survival (OS). We developed a new tumor burden scoring method according to the extent of bone marrow infiltration in five MRI patterns.
View Article and Find Full Text PDFObjectives: To compare the imaging quality, apparent diffusion coefficient (ADC), and the value of assessing bone marrow infiltration between reduced field-of-view diffusion-weighted imaging (r-FOV DWI) and conventional DWI in the lumbar spine of acute leukemia (AL).
Methods: Patients with newly diagnosed AL were recruited and underwent both r-FOV DWI and conventional DWI in the lumbar spine. Two radiologists evaluated image quality scores using 5-Likert-type scales qualitatively and measured signal-to-noise ratio (SNR), contrast-to-noise (CNR), signal intensity ratio (SIR), and ADC quantitatively.
Article Synopsis
- This study focuses on using a specific MRI technique (IVIM) to assess spleen changes in patients with acute leukemia, as the spleen is often affected by this condition.* -
- Researchers compared IVIM parameters and spleen volumes among newly diagnosed leukemia patients and healthy controls to see if these measurements could help identify spleen involvement in leukemia.* -
- Results showed significant differences in IVIM parameters between the groups, particularly highlighting correlations with clinical biomarkers, indicating that IVIM could be valuable for early detection of leukemia's impact on the spleen.*
Article Synopsis
- - The marrow-blood barrier (MBB) regulates how mature blood cells and other substances move between the bone marrow and the bloodstream, playing a vital role in blood cell distribution.
- - Damage to the MBB can lead to increased permeability, which is often seen in blood diseases and tumors as immature cells are found in the blood.
- - Various imaging techniques like DCE-MRI, IVIM, ASL, BOLD-MRI, and microfluidic devices are used to assess the MBB's integrity, helping inform disease understanding and treatment strategies.
To evaluate and compare the performance of synthetic magnetic resonance imaging (SyMRI) in classifying benign and malignant breast lesions and predicting the expression status of immunohistochemistry (IHC) markers. We retrospectively analysed 121 patients with breast lesions who underwent dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and SyMRI before surgery in our hospital. DCE-MRI was used to assess the lesions, and then regions of interest (ROIs) were outlined on SyMRI (before and after enhancement), and apparent diffusion coefficient (ADC) maps to obtain quantitative values.
View Article and Find Full Text PDFObjectives: To study the value of standardized volume and intravoxel incoherent motion (IVIM) parameters of the spleen based on tumor burden for predicting treatment response in newly diagnosed acute leukemia (AL).
Methods: Patients with newly diagnosed AL were recruited and underwent abdominal IVIM diffusion-weighted imaging within one week before the first induction chemotherapy. Quantitative parameters of magnetic resonance imaging (MRI) included the standardized volume (representing volumetric tumor burden) and IVIM parameters (standard apparent diffusion coefficient [sADC]; pure diffusion coefficient []; pseudo-diffusion coefficient []; and pseudo-perfusion fraction [] representing functional tumor burden) of the spleen.
The blood-brain barrier (BBB) is an important structure that maintains the normal function of the central nervous system (CNS). The functional structure of BBB is closely related to diseases of CNS, including degenerative diseases, brain tumours, traumatic brain injury, stroke, etc. Imaging methods were commonly used to monitor the integrity of BBB, such as DCE-MRI, DSC-MRI, and PET, this contributes to understand the process of related diseases and develop appropriate treatment options.
View Article and Find Full Text PDFPurpose: To study the value of quantitative IVIM parameters in evaluating cerebral blood perfusion changes in patients newly diagnosed with acute leukemia (AL) by comparing them with healthy participants.
Materials And Methods: This prospective study consecutively recruited 49 participants with newly diagnosed AL and 40 normal controls between July 2020 and September 2022. All participants underwent an MRI of the brain using an axial T-weighted and an IVIM sequence.
Article Synopsis
- The study evaluated the role of intravoxel incoherent motion diffusion-weighted MRI (IVIM) in assessing renal function in patients with untreated acute leukemia (AL) compared to healthy controls.
- Researchers analyzed parameters like D, D*, f, and standard ADC values from 67 AL patients and 67 matched controls, finding significant differences indicative of impaired renal function in the patients.
- Key findings suggest that certain IVIM parameters, especially lower medullary f values, could serve as important indicators for renal health and overall survival in AL patients.
Remodeling of the periodontal ligament and alveolar bone during axial tooth movement in mice with type 1 diabetes.
Front Endocrinol (Lausanne)
February 2023
Objectives: To observe the elongation of the axial tooth movement in the unopposed rodent molar model with type 1 diabetes mellitus and explore the pathological changes of periodontal ligament and alveolar bone, and their correlation with tooth axial movement.
Methods: The 80 C57BL/6J mice were randomly divided into the streptozotocin(STZ)-injected group (n = 50) and the control group (n = 30). Mice in the streptozotocin(STZ)-injected group were injected intraperitoneal with streptozotocin (STZ), and mice in the control group were given intraperitoneal injection of equal doses of sodium citrate buffer.
Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI.
Front Endocrinol (Lausanne)
November 2022
Article Synopsis
- Bone marrow plays a crucial role in human health, and studying its microstructure can enhance our understanding of bone metabolism differences between genders.
- In this study, 60 young adults underwent MRI scans to evaluate bone marrow characteristics, using a technique called intravoxel incoherent motion (IVIM), which measures diffusion and perfusion without needing contrast agents.
- Results indicated that women had higher true diffusion and perfusion values compared to men, while conventional diffusion values showed no significant gender differences; the study highlights IVIM's potential for non-invasively assessing bone marrow characteristics.
This study aimed to compare MRI quality between conventional fast spin echo T weighted imaging (FSE TWI) with periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) FSE TWI for patients with various porcelain fused to metal (PFM) crown and analyze the value of PROPELLER technique in reducing metal artifacts. Conventional FSE TWI and PROPELLER FSE TWI sequences for axial imaging of head were applied in participants with different PFM crowns: cobalt-chromium (Co-Cr) alloy, pure titanium (Ti), gold-palladium (Au-Pd) alloy. Two radiologists evaluated overall image quality of section in PFM using a 5-point scale qualitatively and measured the maximum artifact area and artifact signal-to-noise ratio (SNR) quantitatively.
View Article and Find Full Text PDFObjective: The aim of the study was to assess the peripheral rim instability and the clinical value of discoid meniscus.
Methods: We retrospectively studied 79 magnetic resonance imaging (MRI) examinations of discoid meniscus from May 2017 to September 2019. The patient symptoms and physical findings were documented.