Melatonin alleviates LPS-induced depression-like behavior in mice by inhibiting ferroptosis by regulating RNA methylation-mediated SIRT6/Nrf2/HO-1 pathway.

Purpose: The objective of this study is to investigate the impact of ferroptosis on depression and elucidate the molecular mechanism underlying melatonin's inhibitory effect on ferroptosis in the treatment of depression.

Methods: In this study, a depression-like behavior model was induced in mice using LPS, and the effect of melatonin on depression-like behavior was evaluated through behavioral experiments (such as forced swimming test (FST) and sucrose preference test (SPT)). Additionally, molecular biological techniques (including real-time fluorescence quantitative PCR, Western blotting, immunoprecipitation) were employed to detect the expression levels and interactions of METTL3, SIRT6 and ferroptosis-related genes in mouse brain tissue.

Liquid Phase Exfoliation of Few-Layer Non-Van der Waals Chromium Sulfide.

Exfoliation of 2D non-Van der Waals (non-vdW) semiconductor nanoplates (NPs) from inorganic analogs presents many challenges ahead for further exploring of their advanced applications on account of the strong bonding energies. In this study, the exfoliation of ultrathin 2D non-vdW chromium sulfide (2D CrS) by means of a combined facile liquid-phase exfoliation (LPE) method is successfully demonstrated. The morphology and structure of the 2D CrS material are systematically examined.

Therapeutic effect of notoginseng saponins before and after fermentation on blood deficiency rats.

Notoginseng saponins (NS) are the active ingredients in (Burk.) F.H.

AMPK activation attenuates central sensitization in a recurrent nitroglycerin-induced chronic migraine mouse model by promoting microglial M2-type polarization.

Background: Energy metabolism disorders and neurogenic inflammation play important roles in the central sensitization to chronic migraine (CM). AMP-activated protein kinase (AMPK) is an intracellular energy sensor, and its activation regulates inflammation and reduces neuropathic pain. However, studies on the involvement of AMPK in the regulation of CM are currently lacking.

METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke.

Background: Stroke is a major medical problem, and novel therapeutic targets are urgently needed. This study investigates the protective role and potential mechanisms of the N6-methyladenosine (m6A) RNA methyltransferase METTL3 against cerebral injury resulting from insufficient cerebral blood flow.

Methods: In this study, we constructed mouse MCAO models and HT-22 cell OGD/R models to mimic ischemic stroke-induced brain injury and neuronal damage.

Relationship between individual differences in pain empathy and task- and resting-state EEG.

Pain empathy is a complex form of psychological inference that enables us to understand how others feel in the context of pain. Since pain empathy may be grounded in our own pain experiences, it exhibits huge inter-individual variability. However, the neural mechanisms behind the individual differences in pain empathy and its association with pain perception are still poorly understood.

Effect of central corneal curvature on corneal material stiffness parameter acquired by dynamic corneal responses.

The stress-strain index (SSI) is a measure of corneal material stiffness, which is obtained using the Corvis ST algorithm based on dynamic corneal response parameters. The reduced SSI corresponds to the longer axial length (AL). In a previous study, we found SSI increases as the corneal curvature flattens, whereas a flatter corneal curvature indicates a longer AL (emmetropia or myopia).

Fiber liquid-pressure sensor with high sensitivity and a wide measurement range using photopolymer.

This paper presents a novel fiber liquid-pressure sensor that uses photopolymer glue to generate Fabry-Perot (F-P) interference, resulting in high sensitivity and a wide measurement range. The sensor comprises a single-mode fiber and photopolymer glue; the latter adheres to the fiber's end face and is decomposed by a 405-nm laser to create an air channel with a diameter of 5.9 µm and a length of 50 µm.

Effect of corneal stiffness decrease on axial length elongation in myopia determined based on a mathematical estimation model.

To investigate the relationship between the corneal material stiffness parameter stress-strain index (SSI) and axial length (AL) elongation with varying severities of myopia, based on a mathematical estimation model. This single-center, cross-sectional study included data from healthy subjects and patients preparing for refractive surgery in the Qingdao Eye Hospital of Shandong First Medical University. Data were collected from July 2021 to April 2022.

Nomogram Prediction for Postoperative Mortality of Orthotopic Liver Transplantation.

Objectives: The purpose of this study was to assess and predict risk factors for death within 30 days after orthotopic liver transplant and to develop a nomogram to predict mortality after liver transplant.

Materials And Methods: We retrospectively studied 185 patients who underwent orthotopic livertransplant at Sichuan Provincial People's Hospital from January 1, 2010, to December 31, 2018. Multivariable logistic regression analyses were used to identify independent risk factors.

Analysis of mA modulator-mediated methylation modification patterns and the tumor microenvironment in lung adenocarcinoma.

Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer. In the development and progression of LUAD, epigenetic aberration plays a crucial role. However, the function of RNA N6-methyladenosine (mA) modifications in the LUAD progression is unknown.

Hemostatic Effect of 20(S)-Panaxadiol by Induced Platelet Aggregation Depending on Calcium Signaling Pathway.

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Manual Removal versus Spontaneous Delivery of the Placenta at Cesarean Section: A Meta-Analysis of Randomized Controlled Trials.

Purpose: Several randomized clinical trials (RCTs) investigated the effects of the manual placental removal on hemorrhage or other hemorrhage-related complications compared with the spontaneous placental removal during cesarean section (CS), while the results remained controversial and were inconsistent. The purpose of this meta-analysis was to quantify the pooled effects of the methods of placental removal on hemorrhage during CS.

Patients And Methods: A systematic literature search was conducted using PubMed, EMBASE, Web of Science, and Google Scholar.

FBXO10 prevents chronic unpredictable stress-induced behavioral despair and cognitive impairment through promoting RAGE degradation.

Aims: Depression is one of the leading causes of disability worldwide. The receptor for advanced glycosylation end products (RAGE) is closely related to chronic stress and is a target of F-box protein O10 (FBXO10) which promotes the degradation of RAGE by ubiquitination. Here, we explored the role of FBXO10 and RAGE in chronic unpredictable stress (CUS)-induced behavioral despair, cognitive impairment, neuroinflammation, and the polarization microglia.