The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition.

PRRX1 (paired related homeobox 1), a member of the paired homeobox family, exhibits an important role in tumor. It is closely correlated to the occurrence of epithelial-mesenchymal transition (EMT). PRRX1 is an important transcription factor regulating EMT and plays an important role in tumor progression.

Source identification of PM at a port and an adjacent urban site in a coastal city of China: Impact of ship emissions and port activities.

Daily PM samples were collected simultaneously at an urban site (UB) and a nearby port-industrial site (PI) on the coast of southeastern China from April 2015 to January 2016. The PM mass concentration at the PI (51.9μgm) was significantly higher than that at the UB.

Spatiotemporal distribution and source apportionment of low molecular weight organic acids in wet precipitation at a coastal city, China.

To investigate the characteristics and sources of low molecular weight (LMW) organic acids in wet precipitation at a coastal city, Xiamen, a total of 313 rainwater samples were collected at seven different functional areas from September 2012 to August 2013. Spatiotemporal characteristics of LMW organic acids as well as pH and electrical conductivity were analyzed. Meanwhile, air mass clusters in different seasons and the positive matrix factorization (PMF) source apportion model were comprehensively used to identify the sources of organic acids.

[Pollution Characteristics of Heavy Metals in PM and Their Human Health Risks Among the Coastal City Group Along Western Taiwan Straits Region, China].

PM samples were collected from 11 sampling sites in the coastal city group along western Taiwan Straits region, China, and these heavy metal elements (Zn, Cu, Pb, Ni, Cr, As) were detected using particle-induced X-ray emission (PIXE) method. The pollution characteristics, enrichment factors and source apportionment of heavy metals in PM were analyzed, and furthermore, their human health risks were determined. The result showed concentration distribution was obviously different between PM and heavy metals in the city group, for the main sources (e.

Chemical composition, structural properties, and source apportionment of organic macromolecules in atmospheric PM in a coastal city of Southeast China.

Particulate matter (PM) associated with the fractions of organic macromolecules, including humic acid (HA), kerogen + black carbon (KB), and black carbon (BC), was determined during summer and winter at urban and suburban sites in a coastal city of southeast China. The organic macromolecules were characterized by elemental analysis (EA), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR), and their sources were identified by using stable carbon/nitrogen isotope (δC/δN) and the Hybrid Single Particle Lagrangian Integrated Trajectory (HYSPLIT) Model. The results showed that HA, kerogen (K), and BC accounted for the range of 3.

Optical properties of PM2.5 and the impacts of chemical compositions in the coastal city Xiamen in China.

Continuous in situ measurements of optical properties of fine aerosols (PM2.5) were conducted in the urbanized coastal city Xiamen in Southeast China from November 2013 to January 2014. PM2.

Increase in hypotonic stress-induced endocytic activity in macrophages via ClC-3.

Extracellular hypotonic stress can affect cellular function. Whether and how hypotonicity affects immune cell function remains to be elucidated. Macrophages are immune cells that play key roles in adaptive and innate in immune reactions.

Extracellular acidosis modulates the endocytosis and maturation of macrophages.

Extracellular acidosis is involved in various pathological situations of central nervous system and the effects are largely mediated by acid sensing ion channels (ASICs). However, it remains unclear whether extracellular acidosis affects immune cells. Macrophages are immune cells that play important role in immune reactions.

Acid-sensing ion channels contribute to the effect of acidosis on the function of dendritic cells.

As an H(+)-gated subgroup of the degenerin/epithelial Na(+) channel family, acid-sensing ion channels (ASICs) were reported to be involved in various physiological and pathological processes in neurons. However, little is known about the role of ASICs in the function of dendritic cells (DCs). In this study, we investigated the expression of ASICs in mouse bone marrow-derived DCs and their possible role in the function of DCs.