Publications by authors named "Wenjia You"
Amacrine cells (ACs) are the most diverse neuronal cell type in the vertebrate retina. Yet little is known about the contribution of ACs to visual processing and retinal disease. A major challenge in evaluating AC function is genetic accessibility.
View Article and Find Full Text PDFArticle Synopsis
- The Cre-loxP system allows precise control of gene modification in the mouse nervous system, but unexpected germline recombination can occur with different Cre driver lines.
- Research shows over half of 64 common Cre driver lines exhibit germline recombination, often influenced by which parent contributes the germline cells.
- The findings reveal that varying transcriptional elements in different Cre lines impact recombination rates, affecting how reliably researchers can use reporters to track genetic modifications.
Suppressor of Hairless [Su(H)] is a DNA-binding protein of the Notch-signaling pathway, which is important for developmental processes and has been implicated in behavior plasticity. It acts as a transcriptional activator in the Notch pathway, but also as a repressor in the absence of Notch signaling. Our previous work has shown that Notch signaling contributes to long-term memory formation in the Drosophila adult brain.
View Article and Find Full Text PDF