Proactive functional classification of all possible missense single-nucleotide variants in .

Clinical exome sequencing has yielded extensive disease-related missense single-nucleotide variants (SNVs) of uncertain significance, leading to diagnostic uncertainty. is one of the most commonly responsible genes for autosomal dominant nonsyndromic hearing loss. According to the gnomAD cohort, approximately one in 100 people harbors missense variants in (missense variants with minor allele frequency > 0.

The S2-S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.

Kv7.4 (KCNQ4) voltage-gated potassium channels control excitability in the inner ear and the central auditory pathway. Mutations in Kv7.

Aspirin inhibits growth of ovarian cancer by upregulating caspase-3 and downregulating bcl-2.

[This retracts the article DOI: 10.3892/ol.2016.

ATP-dependent modulation of MgtE in Mg homeostasis.

Magnesium is an essential ion for numerous physiological processes. MgtE is a Mg selective channel involved in the maintenance of intracellular Mg homeostasis, whose gating is regulated by intracellular Mg levels. Here, we report that ATP binds to MgtE, regulating its Mg-dependent gating.

Aspirin inhibits growth of ovarian cancer by upregulating caspase-3 and downregulating bcl-2.

The aim of the present study was to investigate the effect and mechanism of different concentrations of aspirin in inhibiting the ovarian cancer of p53N236S gene knock-in mice. In total, 28 male p53S mice, with an age range of 4-6 weeks and weight of 20-25 g were selected. The animals were transplanted with SKOV3 cells to establish subdermal human ovarian cancer.