Environmental concentrations of 6PPD and 6PPD-quinone induce hepatic lipid metabolism disorders in male black-spotted frogs.

Aquatic environments are generally contaminated with N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its oxidation product 6PPD-quinone (6PPD-Q). Recently, 6PPD-Q was found lethally toxic to some specific species, especially salmonid silverfish. This study investigated male black-spotted frogs (Pelophylax nigromaculatus) exposed to 6PPD and 6PPD-Q with different environmental concentrations (0, 1, and 10 μg/L) for 21 days, after which biochemical, metabolomic, gene expression analyses, and molecular docking were conducted.

Life cycle assessment of biochar for sustainable agricultural application: A review.

Biochar application is an effective strategy to address Agro-climatic challenges. However, the agro-environmental impacts of different biochar technology models are lacking of systematic summaries and reviews. Therefore, this paper comprehensively reviews recent developments derived from published literature, delving into the economic implications and environmental benefits of three distinct process namely technologies-pyrolysis, gasification, and hydrothermal carbonization.

Experimental and Meshless Numerical Simulations on the Crack Propagation of Semi-Circular Bending Specimens Containing X-Shaped Fissures Under Three-Point Bending.

Cracks in rock and concrete have a great adverse effect on the stability of engineering structures; however, there are few studies on X-shaped fissures which widely exist in rock and concrete structures. Based on this background, three-point bending fracture tests of SCB specimens containing X-shaped fissures are carried out. The momentum equations in the SPH method are improved, and the crack propagations of SCB specimens under three-point bending are simulated.

Screening, genotyping and haematological analysis of glucose-6-phosphate dehydrogenase deficiency in the blood donors of Wuxi City, China.

Background And Objectives: To investigate the prevalence, genotype and haematological characteristics of glucose-6-phosphate dehydrogenase (G6PD) deficiency in the blood donor population of Wuxi area (Jiangsu Province, China) and to assess the impact of their red blood cell (RBC) units on clinical transfusion.

Materials And Methods: We conducted genotyping and large-scale screening for G6PD enzyme activity in the blood donors of Wuxi City. In addition, we assessed the haematological parameters of G6PD-deficient and non-deficient blood donors, and investigated the adverse transfusion reactions in patients transfused with G6PD-deficient blood.

Metabolomics reveals the lipid metabolism disorder in Pelophylax nigromaculatus exposed to environmentally relevant levels of microcystin-LR.

Cyanobacterial blooms have emerged as a significant environmental issue worldwide in recent decades. However, the toxic effects of microcystin-LR (MC-LR) on aquatic organisms, such as frogs, have remained poorly understood. In this study, frogs (Pelophylax nigromaculatus) were exposed to environmentally relevant concentrations of MC-LR (0, 1, and 10 μg/L) for 21 days.

Tomato SlWRKY3 Negatively Regulates Resistance via .

is considered the second most important fungal plant pathogen, and can cause serious disease, especially on tomato. The gene encodes a receptor-like kinase that can positively regulate plant resistance to . Here, we identified a tomato WRKY transcription factor SlWRKY3 that binds to the W-box on the promoter.

Linguistic feedback supports rapid adaptation to acoustically degraded speech.

Humans can quickly adapt to recognize acoustically degraded speech, and here we hypothesize that the quick adaptation is enabled by internal linguistic feedback - Listeners use partially recognized sentences to adapt the mapping between acoustic features and phonetic labels. We test this hypothesis by quantifying how quickly humans adapt to degraded speech and analyzing whether the adaptation process can be simulated by adapting an automatic speech recognition (ASR) system based on its own speech recognition results. We consider three types of acoustic degradation, i.

Paternal exposures to endocrine-disrupting chemicals induce intergenerational epigenetic influences on offspring: A review.

Endocrine-disrupting chemicals (EDCs) are ubiquitous in ecological environments and have become a great issue of public health concern since the 1990 s. There is a deep scientific understanding of the toxicity of EDCs. However, recent studies have found that the abnormal physiological functions of the parents caused by EDCs could be transmitted to their unexposed offspring, leading to intergenerational toxicity.

SlTCP24 and SlTCP29 synergistically regulate compound leaf development through interacting with SlAS2 and activating transcription of SlCKX2 in tomato.

The complexity of compound leaves results primarily from the leaflet initiation and arrangement during leaf development. However, the molecular mechanism underlying compound leaf development remains a central research question. SlTCP24 and SlTCP29, two plant-specific transcription factors with the conserved TCP motif, are shown here to synergistically regulate compound leaf development in tomato.

Eclampsia, fertilization and the risk of preterm birth: a retrospective cohort study based on 2,880,759 samples.

Background: Eclampsia and in vitro fertilization (IVF) are independent risk factors for preterm birth. Understanding the combined effects of multiple risk factors for preterm birth is critical to making accurate and personalized risk predictions. This study aimed to explore the interaction between eclampsia and IVF on the risk of preterm birth.

Effects and mechanism of action of Chrysanthemum morifolium (Jinsi Huangju) on hyperlipidemia and non-alcoholic fatty liver disease.

As a popular healthy tea beverage, Jinsi Huangju has been consumed in China for hundreds of years. However, its active ingredients which dissolved in hot water have not been fully determined. In this study, 14 compounds were identified by different spectroscopic techniques, including 11 compounds identified in this plant for the first time.

Speech recognition in echoic environments and the effect of aging and hearing impairment.

Temporal modulations provide critical cues for speech recognition. When the temporal modulations are distorted by, e.g.

Physiological responses of Ampithoe valida and its feeding potential on Ulva prolifera.

Large numbers of Amphipoda feed on floating green tide macroalgae in the Yellow Sea, among which Ampithoe valida has a high abundance in the stable and decline periods. Amphipoda preferentially feed on Ulva. Under different temperatures, salinities, and pH, the physiological responses of A.

Establishment of a visual gene knockout system based on CRISPR/Cas9 for the rare actinomycete Nonomuraea gerenzanensis.

Objectives: To develop a modified CRISPR/Cas9 system with the β-glucuronidase (GusA) reporter and a dual sgRNA cassette for Nonomuraea gerenzanensis (N. gerenzanensis).

Results: With the aid of a visual GusA reporter, the complicated and tedious process of cloning and gene identification could be abandoned entirely in the genetic editing of N.

SlBBX20 attenuates JA signalling and regulates resistance to Botrytis cinerea by inhibiting SlMED25 in tomato.

Jasmonic acid (JA) plays an important role in regulating plant growth and defence responses. Here, we show that a transcription factor that belongs to the B-box (BBX) family named SlBBX20 regulates resistance to Botrytis cinerea in tomato by modulating JA signalling. The response to JA was significantly suppressed when SlBBX20 was overexpressed in tomato.

Maslinic Acid Suppresses High Glucose-induced Inflammation by Epigenetically Inhibiting TXNIP Expression.

Objective: Hyperglycemia-induced inflammation and subsequent endothelial injuries ultimately lead to the pathogenesis of cardiovascular diseases associated with high mortality, such as atherosclerosis. Maslinic acid (MA) is a phytochemical with anti-inflammatory activity. However, it remains unknown whether it can inhibit diabetes-associated cardiovascular inflammation.

Effect of Enhanced Recovery after Surgery with Integrated Traditional Chinese and Western Medicine on Postoperative Stress Response of Patients with Gastrointestinal Tumors.

Objective: To investigate the effect of enhanced recovery after surgery (ERAS) with integrated traditional Chinese and Western medicine on postoperative stress response of patients suffering from gastrointestinal tumors.

Methods: A total of 74 patients with gastrointestinal tumors who underwent surgical treatment in our hospital from April 2019 to March 2021 were recruited and randomized into the control group and the observation group (1 : 1). The control group received routine treatment and care, while the observation group received ERAS plus integrated traditional Chinese and Western medicine.

Fresh hetero-metallic compound as luminescent sensor for detection of CS and inhibitory activity on children diabetes.

The combination of the dicarboxylate ligand of 2-aminoterephthalic acid (HL), Cd(NO)·4HO, and KNO under hydrothermal condition formed a fresh hetero-metallic coordination polymer, namely, [CdK(L)(HO)] (1). The compound exhibited a high luminescence intensity at normal environment as well as high sensitivity and selectivity in the measurement of CS. The effect of the fresh compound on childhood diabetes was investigated.

Asymmetrical cross-modal influence on neural encoding of auditory and visual features in natural scenes.

Natural scenes contain multi-modal information, which is integrated to form a coherent perception. Previous studies have demonstrated that cross-modal information can modulate neural encoding of low-level sensory features. These studies, however, mostly focus on the processing of single sensory events or rhythmic sensory sequences.

Heterogeneous Ti/PbO-electro-Fenton degradation of aromatic methane dyes using industrial pyrite waste slag as catalyst.

It is imperative to search the eco-friendly and cost-effective technologies for degrading contaminants. Coupling the effect of Ti/PbO at the anode with heterogeneous electro-Fenton was an efficient method. Industrial pyrite waste slag characterized by a variety of methods had catalytic performance and stable performance to activate hydrogen peroxide (HO) into hydroxyl radical (∙OH).

Copper-Catalyzed Aminoarylation of Alkenes via Aminyl Radical Addition and Aryl Migration.

We describe a new strategy for aminoarylation of alkenes by copper-catalyzed smiles rearrangement using -benzoylhydroxylamines as the amine reagent. This method affords various β-amino amide derivatives possessing a quaternary carbon center with wide functional group tolerance and high regioselectivity. The mechanistic studies indicate that the transformation can involve aminyl radical intermediates under acid-free condition.