Integrating rare variant genetics and brain transcriptome data implicates novel schizophrenia putative risk genes.

The etiology of schizophrenia is elusive, in part due to its polygenic nature. Genome-wide association studies (GWAS) have successfully identified hundreds of schizophrenia risk loci, that are pinpointed to over one hundred genes through fine mapping. Besides common variants with relatively small effect size from GWAS, rare variants or ultra rare variants also play a significant role in conferring the schizophrenia risk from SCHEMA (Schizophrenia Exome Sequencing Meta-Analysis) results.

Biomechanical Analysis of Different Internal Fixation Combined with Different Bone Grafting for Unstable Thoracolumbar Fractures in the Elderly.

This research was developed to accurately evaluate the unstable fractures of thoracolumbar before and after surgery and discuss the treatment timing and methods. Three-dimensional (3D) finite element method was adopted to construct the T-L segment model of human body. The efficiency of percutaneous kyphoplasty (PKP) and percutaneous vertebroplasty (PVP), two commonly used internal fixation procedures, was retrospectively compared.

On the Burr XII-moment exponential distribution.

In this study, a new flexible lifetime model called Burr XII moment exponential (BXII-ME) distribution is introduced. We derive some of its mathematical properties including the ordinary moments, conditional moments, reliability measures and characterizations. We employ different estimation methods such as the maximum likelihood, maximum product spacings, least squares, weighted least squares, Cramer-von Mises and Anderson-Darling methods for estimating the model parameters.

Jump-seq: Genome-Wide Capture and Amplification of 5-Hydroxymethylcytosine Sites.

5-Hydroxymethylcytosine (5hmC) arises from the oxidation of 5-methylcytosine (5mC) by Fe and 2-oxoglutarate-dependent 10-11 translocation (TET) family proteins. Substantial levels of 5hmC accumulate in many mammalian tissues, especially in neurons and embryonic stem cells, suggesting a potential active role for 5hmC in epigenetic regulation beyond being simply an intermediate of active DNA demethylation. 5mC and 5hmC undergo dynamic changes during embryogenesis, neurogenesis, hematopoietic development, and oncogenesis.

The nested joint clustering via Dirichlet process mixture model.

This article focuses on the clustering problem based on Dirichlet process (DP) mixtures. To model both time invariant and temporal patterns, different from other existing clustering methods, the proposed semi-parametric model is flexible in that both the common and unique patterns are taken into account simultaneously. Furthermore, by jointly clustering subjects and the associated variables, the intrinsic complex shared patterns among subjects and among variables are expected to be captured.