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Publications by authors named "Wenhui Qiao"

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Synopsis of recent research by authors named "Wenhui Qiao"

  • - Wenhui Qiao's recent research primarily focuses on the role of apolipoprotein E (APOE) isoforms in Alzheimer's disease (AD) pathology, particularly how different APOE variants (APOE2, APOE3, and APOE4) affect microglial activation, cerebrovascular integrity, and neurodegeneration.
  • - Key findings indicate that APOE4 restricts microglial response, exacerbates amyloid pathology, and impairs cerebrovascular function, thereby worsening cognitive outcomes in models of AD, while APOE2 exhibits contrasting effects on TDP-43 related toxicity.
  • - Additionally, insights from Qiao’s studies into the modulating role of TREM2 on microglial responses suggest potential therapeutic strategies targeting TREM2 signaling for better management of AD and related neurodegenerative conditions.

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