NIR-Absorbing Tetraphenylethene-Containing bisBODIPY Nanoplatforms Demonstrate Effective Lysosome-Targeting and Combinational Phototherapy.

Photosensitizer-based phototherapies, including photodynamic therapy (PDT) and photothermal therapy (PTT), offer safe treatment modalities for tumor ablation with spatiotemporal precision. After photons are absorbed, PDT creates localized chemical damage by generating reactive oxygen species (ROS), while PTT induces localized thermal damage. However, PDT still faces hypoxic tumor challenges, while PTT encounters issues related to heat resistance and potential overheating.

Score-based generative model-assisted information compensation for high-quality limited-view reconstruction in photoacoustic tomography.

Photoacoustic tomography (PAT) regularly operates in limited-view cases owing to data acquisition limitations. The results using traditional methods in limited-view PAT exhibit distortions and numerous artifacts. Here, a novel limited-view PAT reconstruction strategy that combines model-based iteration with score-based generative model was proposed.

Unsupervised disentanglement strategy for mitigating artifact in photoacoustic tomography under extremely sparse view.

Traditional methods under sparse view for reconstruction of photoacoustic tomography (PAT) often result in significant artifacts. Here, a novel image to image transformation method based on unsupervised learning artifact disentanglement network (ADN), named PAT-ADN, was proposed to address the issue. This network is equipped with specialized encoders and decoders that are responsible for encoding and decoding the artifacts and content components of unpaired images, respectively.

High-resolution iterative reconstruction at extremely low sampling rate for Fourier single-pixel imaging via diffusion model.

The trade-off between imaging efficiency and imaging quality has always been encountered by Fourier single-pixel imaging (FSPI). To achieve high-resolution imaging, the increase in the number of measurements is necessitated, resulting in a reduction of imaging efficiency. Here, a novel high-quality reconstruction method for FSPI imaging via diffusion model was proposed.

High-speed real 3D scene acquisition and 3D holographic reconstruction system based on ultrafast optical axial scanning.

The lack of three-dimensional (3D) content is one of the challenges that have been faced by holographic 3D display. Here, we proposed a real 3D scene acquisition and 3D holographic reconstruction system based on ultrafast optical axial scanning. An electrically tunable lens (ETL) was used for high-speed focus shift (up to 2.

SIK2 Improving Mitochondrial Autophagy Restriction Induced by Cerebral Ischemia-Reperfusion in Rats.

Previous studies have shown that Salt-induced kinase-2(SIK2) is involved in the regulation of various energy-metabolism-related reactions, and it also can regulate angiogenesis after cerebral ischemia-reperfusion. However, it is unclear whether SIK2 can regulate energy metabolism in cerebral ischemia-reperfusion injury. As mitochondria plays an important role in energy metabolism, whether SIK2 regulates energy metabolism through affecting mitochondrial changes is also worth to be explored.

A T-cell-dependent antibody response (TDAR) method in BALB/c mice based on a cytometric bead array.

Most current methods to assess T-cell-dependent antibody responses (TDAR) are semi-quantitative and based on measures of antibody titer generated against a standard antigen like keyhole limpet hemocyanin (KLH). The precision, sensitivity, and convenience of TDAR assays might be improved by applying rapid, sensitive, specific cytometric bead assays (CBA). In the study here, KLH antigen was covalently coupled onto the surface of cytometric beads using immune microsphere technology, and IgM antibody capture spheres were prepared for use in pretreatment processing of samples.

A Novel Algorithm With Paired Predictive Indexes to Stratify the Risk Levels of Neonates With Invasive Bacterial Infections: A Multicenter Cohort Study.

Background: Our aim was to develop a predictive model comprising clinical and laboratory parameters for early identification of full-term neonates with different risks of invasive bacterial infections (IBIs).

Methods: We conducted a retrospective study including 1053 neonates presenting in 9 tertiary hospitals in China from January 2010 to August 2019. An algorithm with paired predictive indexes (PPIs) for risk stratification of neonatal IBIs was developed.

Antibiotic resistance in neonates in China 2012-2019: A multicenter study.

Background: To investigate antibiotic resistance of pathogens responsible for neonatal invasive bacterial infections (IBIs) in China.

Methods: Cross-sectional study of neonates with IBI evaluated in nine hospitals in China (January 2012-August 2019). Antibiotic resistance patterns of pathogens responsible for neonatal IBIs were analyzed.

A sequential guide to identify neonates with low bacterial meningitis risk: a multicenter study.

Objective: To derive and validate a predictive algorithm integrating clinical and laboratory parameters to stratify a full-term neonate's risk level of having bacterial meningitis (BM).

Methods: A multicentered dataset was categorized into derivation (689 full-term neonates aged ≤28 days with a lumbar puncture [LP]) and external validation (383 neonates) datasets. A sequential algorithm with risk stratification for neonatal BM was constructed.

The Role of Ceria in a Hybrid Catalyst toward Alkaline Water Oxidation.

Ceria-based catalysts for the oxygen evolution reaction (OER) have received keen interest in recent years owing to their potential excellent cost performance. However, despite a flurry of research activities, the mechanism on how ceria activates those hybrid catalysts is still puzzling. Herein, by controllably modifying the oxidation state of Ce in ceria, it was revealed that creating Ce species, which are redox-coupled to Ce under OER conditions, could enhance the conductivity and optimize the OH* binding, leading to greatly improved OER activity of the catalysts.

Hybrid hollow spheres of carbon@CoNiMoO as advanced electrodes for high-performance asymmetric supercapacitors.

Combining pseudocapacitive materials with conductive substrates is an effective approach to enhance the overall performance of electrodes for supercapacitors. Herein, NiMoO4 nanosheets were grown on the surface of porous carbon nanospheres (PCNS) that were derived from cyclodextrin, resulting in PCNS@NiMoO4 hollow nanospheres. Co was further doped into NiMoO4 which gave rise to a composite PCNS@CoxNi1-xMoO4.

Factors related to retinal haemorrhage in infants born at high risk.

Purpose: This study aims to determine risk factors for retinal haemorrhage (RH) in high-risk infants.

Methods: A total of 3123 cases with high-risk pregnancy and/or neonatal asphyxia 72 hr after delivery were enrolled into this study. Fundus examinations were performed on newborns utilizing a wide-angle imaging system (RetCam III).