The role of ferroptosis in colorectal cancer and its potential synergy with immunotherapy.

Colorectal cancer (CRC) is one of the most prevalent and deadly malignancies worldwide. Recently, ferroptosis, a novel form of regulated cell death characterized by iron dependency and lipid peroxidation, has garnered significant attention from researchers. The mechanisms underlying ferroptosis, including intracellular iron levels, lipid peroxidation, and antioxidant system regulation, offer new insights into cancer treatment strategies.

[Relation between angiogenesis, fibrinolysis and invasion/metastasis in breast cancer].

Objective: To investigate the relation between angiogensis, fibrinolysis and invasion/metastasis in breast cancer.

Methods: The expression of urokinase-type plasminogen activator (uPA) and microvascular density (MVD) was immunohistochemically studied in 110 patients with primary breast cancer.

Results: High uPA expression was found in 59 patients (53.