Publications by authors named "Wenhe Guo"
Article Synopsis
- Recent reports highlight increasing clinical adverse drug reactions (ADRs) associated with Senna obtusifolia, particularly its hepatotoxic effects.
- In a study, repeated administration of Senna obtusifolia Aqueous Extract (SE) confirmed the liver as the primary target organ for toxicity, with additional in vitro verification of hepatotoxicity.
- The study's findings suggest that SE-induced liver damage may be linked to inflammation, as indicated by elevated levels of pro-inflammatory cytokines and specific gene and protein expressions in rat livers and liver cancer cells.
