A chromosome-level genome assembly of big-barbel schizothorcin, Schizothorax macropogon.

Big-barbel schizothorcin (Schizothorax macropogon), an endemic and vulnerable species to the mid-reaches of the Yarlung Zangbo River, epitomizes survival in harsh conditions yet suffers significant population contractions due to human activities. This species was the subject of our study in which we leveraged PacBio, MGI-Seq, and Hi-C data to assemble a chromosome-scale genome. This assembly comprises 25 pseudo-chromosomes, yielding a genome size of 1.

Research on Video Monitoring Technology for Galloping of OCS Additional Conductors of High-Speed Railway in Strong Wind Zone.

The strong wind environment causes the additional conductor of the overhead contact system (OCS) of the Lanzhou-Xinjiang high-speed railway to gallop, significantly impacting the safe operation of the train. This paper presents the design of an online monitoring system for the galloping of additional conductors in the OCS, utilizing video monitoring for accurate and real-time assessment. Initially, the dynamics of the OCS additional conductor and its operational environment are examined, leading to the selection of suitable data transmission and power supply methods to finalize the camera configuration.

Molecular Engineering to Construct MoS with Expanded Interlayer Spacing and Enriched 1T Phase for "Rocking-Chair" Aqueous Calcium-Ion Pouch Cells.

The moderate working voltage and high capacity of transition metal dichalcogenides (TMDs) make them promising anode materials for aqueous calcium-ion batteries (ACIBs). However, the large radius and two charges of Ca cause TMDs to exhibit poor performance in ACIBs. Therefore, effective regulation strategies are crucial for enabling the application of TMDs in ACIBs.

Hyperlipidemia impairs bone repair and regeneration via miR-193a-3p/STMN1/PI3K/Akt axis.

Hyperlipidemia, a metabolic disease characterized by excessive blood lipid, disturbs bone metabolism by shifting cell fate of bone marrow stromal cells (BMSCs) towards adipogenic differentiation, thus resulting in poor bone regeneration and osseointegration of implants. Among numerous factors affecting hyperlipidemic bone metabolism, non-coding RNAs play an essential role in post-transcriptional regulation. Our previous study has shown that miR-193a-3p levels were elevated in hyperlipidemia, which hindered implant osseointegration and BMSCs function.

Driving effects of spatiotemporal evolution of the water resources carrying capacity in the Yellow River Basin (Henan section).

The water resources carrying capacity (WRCC) is a crucial indicator for assessing social, economic and ecological sustainability supported by water resources. While there are abundant studies on the WRCC, there remains a need to thoroughly analyze the driving effects of WRCC evolution. In this study, an index-based WRCC evaluation system was constructed, and a comprehensive evaluation model was employed to assess the spatiotemporal evolution of the WRCC in the Yellow River Basin (YRB) (Henan section).

Wildfires are associated with increased emergency department visits for anxiety disorders in the western United States.

As wildfires increasingly impact the global economy and public health, understanding their effects is crucial. Particularly, the relationship between wildfires and anxiety disorders remains unclear. In this study, we explore this association by analyzing 1,897,865 emergency department visits for anxiety disorders in the western United States.

Hydrogel local drug delivery systems for postsurgical management of tumors: and perspectives.

Surgery is one of the primary treatments for solid tumors. However, the incomplete resection of tumor cells and the immunosuppressive microenvironment make the issue of postsurgical tumor recurrence a great challenge. Furthermore, a wide range of requirements, including ensuring effective hemostasis, implementing prophylactic measures against infection, and promoting wound healing, were also raised in the postsurgical management of tumors.

Modular synthesis of triphenylphosphine-derived cage ligands for rhodium-catalyzed hydroformylation applications.

Four new triphenylphosphine-derived cage ligands were modularly synthesized dynamic imine chemistry (DIC), and their absolute structures were characterized by single crystal X-ray diffraction (SXRD), nuclear magnetic resonance (NMR) and high resolution mass spectroscopy (HRMS). In contrast to small-molecule analogues, cage ligands demonstrate superior activity and selectivity. The Rh/Cage-L2 catalyst exhibits remarkable performance with an aldehyde selectivity of 89%, accompanied by a TOF value of 2665 h and an / ratio of 2.

Physicochemical properties of bacterial cellulose from a strain of Komagataeibacter intermedius and analytical studies on its application.

A high bacterial cellulose (BC) producing Komagataeibacter intermedius (KEI6 strain) was isolated from water kefir grains in Xinjiang, China. Under optimized culture conditions, the KEI6 strain was able to produce BC (KEI6-BC) up to 7.03 g/L dry weight.

The inhibitory efficacy of Ginsenoside Rg3 on proliferation and migration of colonic carcinoma cells through the JAK3/STAT5 signaling pathway.

Objective: To elucidate the efficacy of Ginsenoside Rg3 on the reproduction and immigration of HCT-116 cells and its molecular mechanism.

Methods: Analysis of the cell cycle along with the colony formation assay, and MTT test were performed to detect the effect of Ginsenoside Rg3 (GRg3) on proliferation of HCT-116 cells. Transwell assay and Cell scratch wound method were carried out to determine the impact on the immigration.

Wildland Fire-Related Smoke PM and Cardiovascular Disease ED Visits in the Western United States.

Background: The impact of short-term exposure to fine particulate matter (PM ) due to wildland fire smoke on the risk of cardiovascular disease (CVD) remains unclear. We investigated the association between short-term exposure to wildfire smoke PM and Emergency Department (ED) visits for acute CVD in the Western United States from 2007 to 2018.

Methods: ED visits for primary or secondary diagnoses of atrial fibrillation (AF), acute myocardial infarction (AMI), heart failure (HF), stroke, and total CVD were obtained from hospital associations or state health departments in California, Arizona, Nevada, Oregon, and Utah.

Regulating the interlayer SO-induced rebound of SeO in green rust coupled with iron nanoparticles for groundwater remediation.

Green rust (GR) is an interlayer anion-containing Fe(II)/Fe(III) mineral material that is versatile in removing a series of ionic contaminants in water. Taking SeO (Se(VI)) as the target contaminant, this study identified that the removal processes of Se(VI) by GR could be divided into three stages: initial rapid interlayer exchange, followed by a rebound, and finally slow removal. In addition, as the percentage of SO in GR interlayer increased, the Se(VI) removal by GR gradually decreased.

Transcriptome analysis uncovers the expression of genes associated with growth in the gills and muscles of white shrimp (Litopenaeus vannamei) with different growth rates.

Litopenaeus vannamei is a crucial species in aquaculture. The gene expression patterns associated with distinct growth rates are not well understood. To investigate this, we used RNA-seq to study the underlying growth mechanism of L.

Multiresolution Analysis of HRRR Meteorological Parameters and GOES-R AOD for Hourly PM Prediction.

High-resolution, comprehensive exposure data are crucial for accurately estimating the human health impact of PM. In recent years, satellite remote sensing data have been increasingly utilized in PM models to overcome the limited spatial coverage of ground monitoring stations. However, data gaps in satellite-retrieved parameters such as aerosol optical depth (AOD), the sparsity of regulatory air quality monitors for model training, and nonlinear relationships between PM and meteorological conditions can affect model performance and cause data gaps in most existing PM models.

Role of immune cells in mediating the effect of gut microbiota on Hashimoto's thyroiditis: a 2-sample Mendelian randomization study.

Purpose: Hashimoto's thyroiditis (HT) is one of the most commonly encountered types of autoimmune thyroid disorders (AITDs), influenced by environmental factors, genetics, and the immune system. Previous research has shown a correlation between gut microbiota and HT, as well as the involvement of immune cells in its onset and progression. We aimed to investigate whether immune cells act as intermediaries in the causal relationship between gut microbiota and HT.

Exosomes derived from apical papilla stem cells improve NASH by regulating fatty acid metabolism and reducing inflammation.

Background: Apical papilla stem cells (SCAPs) exhibit significant potential for tissue repair, characterized by their anti-inflammatory and pro-angiogenic properties. Exosomes derived from stem cells have emerged as safer alternatives that retain comparable physiological functions. This study explores the therapeutic potential of exosomes sourced from SCAPs in the treatment of non-alcoholic steatohepatitis (NASH).

A Critical Review of Phenomenological Research Related to Schizophrenia in China.

Introduction: Phenomenological qualitative research delves into the essence and meaning of phenomena through subjects' lived experiences. Despite its widespread use in humanities disciplines, its integration with psychopathology is rare in China.

Methods: We systematically reviewed phenomenological studies on schizophrenia in China to assess their content and quality and offer insights for future research.

Genetically predicted blood metabolites mediate relationships between gut microbiota and ovarian cancer: a Mendelian randomization study.

Background And Purpose: While there is evidence that gut microbiota (GM) and blood metabolites are associated with ovarian cancer (OC), the precise mechanisms underlying this relationship are still unclear. This study used Mendelian randomization (MR) to elucidate the causal connections between GM, blood metabolite biomarkers, and OC.

Methods: In this study, we leveraged summary data for GM (5,959 individuals with genotype-matched GM), blood metabolites (233 circulating metabolic traits with 136,016 participants), and OC (63,702 participants with 23,564 cases and 40,138 controls) from genome-wide association studies (GWASs).