Publications by authors named "Wenhan Bian"
AQP5 deficiency promotes the senescence of lens epithelial cells through mitochondrial dysfunction.
Biochem Biophys Res Commun
November 2023
Article Synopsis
- Cataracts are a common eye disease that causes lens opacity and can lead to blindness, and this study focuses on the role of Aquaporin 5 (AQP5) in lens epithelial cell aging.
- Researchers isolated lens epithelial cells from mice with and without AQP5 and used various techniques to analyze changes in cell aging markers and mitochondrial health.
- The findings indicate that a lack of AQP5 causes increased aging markers and mitochondrial dysfunction in lens cells, suggesting that targeting AQP5 could offer new treatment options for cataracts.
As a water channel protein, aquaporin 5 (AQP5) is essential for the maintenance of the normal physiological functions of ocular tissues. This review provides an overview of the expression and function of AQP5 in the eye and discusses their role in related eye diseases. Although AQP5 plays a vital role in ocular functions, such as maintaining corneal and lens transparency, regulating water movement, and maintaining homeostasis, some of its functions in ocular tissues are still unclear.
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