Publications by authors named "Wenging Hao"
Pollen-induced oxidative DNA damage response regulates miRNAs controlling allergic inflammation.
Am J Physiol Lung Cell Mol Physiol
December 2017
Article Synopsis
- A mucosal oxidative burst caused by pollen exposure contributes to allergic inflammation, primarily through oxidative genomic damage, notably involving a compound called 8-oxoG.
- The protein OGG1 interacts with 8-oxoG, promoting inflammation and altering small regulatory RNA levels and T helper 2 (Th2) cytokine expression in the lungs of mice exposed to ragweed pollen.
- Research shows that manipulating specific micro-RNAs can reduce allergic responses by controlling the production of key cytokines, highlighting the importance of OGG1 signaling in allergy-related immune reactions.