Publications by authors named "Wengang Si"
Article Synopsis
- - This study explores how specific genetic variations (polymorphisms) in the PD-L1 gene are linked to the risk and outcomes for patients with epithelial ovarian cancer (EOC).
- - Researchers analyzed data from 568 patients and 532 healthy women, identifying that certain genotypes (rs2297136 AG + GG) are associated with poorer progression-free survival (PFS) and overall survival (OS) compared to another genotype (AA).
- - Results indicate that the presence of the rs2297136 polymorphism not only affects the expression of the PD-L1 protein but also correlates with worse outcomes for patients, highlighting its potential role as a biomarker in EOC treatment.
CTLA-4 polymorphism contributes to the genetic susceptibility of epithelial ovarian cancer.
J Obstet Gynaecol Res
May 2022
Aim: Cytotoxic T-lymphocyte antigen-4 (CTLA-4), an inhibitory molecule on T-cells, plays a key role in tumorigenesis and progression. In the present study, we investigated the effects of three polymorphisms in the CTLA-4 gene on the risk of epithelial ovarian cancer and the clinical outcomes of patients.
Methods: A case-control study was performed in 527 epithelial ovarian cancer patients and 532 controls.
Genetic polymorphisms in and genes are associated with prognosis in epithelial ovarian cancer patients.
Int J Gynecol Cancer
September 2019
Objective: DNA mismatch repair deficiency is not only thought to promote tumorigenesis but is also suggested to be associated with platinum-based chemotherapy treatment. In this study, we investigated the effects of two genetic polymorphisms in the and genes on the risk of epithelial ovarian cancer and the clinical outcome of patients treated with platinum-based chemotherapy.
Methods: A case-control study was performed in 536 epithelial ovarian cancer patients and 532 control women.