Publications by authors named "Wengang Hu"

Background Hypertrophic scarring is an abnormal condition involving excessive fibroblast activation, aberrant extracellular matrix deposition, and persistent inflammation. Current treatments have limited efficacy and potential adverse effects, necessitating the development of new approaches. Purpose In this study, we investigated the effects of artesunate (ART) on hypertrophic scar (HS) formation and explored the underlying cellular and molecular mechanisms.

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Dendritic epidermal T cells (DETCs) are a unique subset of γδ T cells that reside predominantly in mouse epidermis; yet, their antitumor functions remain enigmatic. In this study, we report that DETCs mediate potent and exquisitely selective cytotoxicity against diverse tumor types while sparing healthy cells. In vitro, DETCs induced apoptosis in melanoma, hepatoma, colon carcinoma, and lymphoma lines in a dose- and time-dependent manner that required direct cell-cell contact.

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  • A study compared a new blood collection technique from mice, called inferior vena cava puncture under continuous cardiac perfusion (IVCP-UCCP), to the traditional cardiac puncture (CP) method.
  • The results revealed that IVCP-UCCP collected over twice the amount of usable blood compared to CP, without affecting blood cell composition or viability.
  • This improved method allows for more efficient use of limited blood resources in mice, offering benefits for both scientific research and ethical considerations, and could be applied to other small animal models as well.
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  • - STING is identified as a vital immune mediator that helps resolve inflammation and aids in skin repair by regulating the movement and function of macrophages during wound healing.
  • - Mice lacking STING showed delayed wound healing due to persistent TNF-α+ leukocytes and impaired recruitment of macrophages, highlighting its role in controlling myeloid cell trafficking to wounds.
  • - The study reveals that STING enhances macrophage migration through STAT3 activation and regulates chemokine production, suggesting potential therapeutic targets for enhancing wound healing and treating inflammatory diseases.
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  • Macrophages play dual roles in skin wound healing, switching from proinflammatory (M1) to anti-inflammatory (M2) states, which is crucial for effective recovery.
  • The study identifies fibroblast-derived exosomes as key players that regulate this transition in macrophage activation without direct cell contact, enhancing their responsiveness to changes in the healing environment.
  • Administering these exosomes can correct dysfunctional inflammation in chronic wounds, presenting a promising therapeutic avenue for improving healing in inflammatory conditions.
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Dysregulated macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2 phenotypes underlies impaired cutaneous wound healing. This study reveals Vγ4 γδ T cells spatiotemporally calibrate macrophage trajectories during skin repair via sophisticated interferon-γ (IFN-γ) conditioning across multiple interconnected tissues. Locally within wound beds, infiltrating Vγ4 γδ T cells directly potentiate M1 activation and suppress M2 polarization thereby prolonging local inflammation.

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Background: The breakdown of intestinal barrier integrity occurs after severe burn injury and is responsible for the subsequent reactions of inflammation and oxidative stress. A new protective strategy for the intestinal barrier is urgently needed due to the limitations of the traditional methods. Recently, the application of nanoparticles has become one of the promising therapies for many inflammation-related diseases or oxidative damage.

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Macrophages are the main cells shaping the local microenvironment during wound healing. As the prime T cells in the skin, γδ T cells participate in regulating microenvironment construction, determining their mutual regulation helps to understand the mechanisms of wound healing, and explore innovative therapeutic options for wound repair. This review introduced their respective role in wound healing firstly, and then summarized the regulatory effect of γδ T cells on macrophages, including chemotaxis, polarization, apoptosis, and pyroptosis.

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  • γδ T cells are essential for the skin's immune defense against damage and infections, differing from conventional αβ T cells in their characteristics.
  • In adult mice, key subsets of γδ T cells, like dendritic epidermal T cells (DETCs), Vγ4, and Vγ6, are crucial for skin wound repair through their coordination and interaction.
  • The review explores the derivation, development, colonization, and activation of γδ T cells, focusing on their roles in both acute and chronic wound healing to inform research on human epidermal γδ T cells and potential skin treatment options.
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Ureteral stent removal by an extraction string is advantageous. However, the increased risk of complications attributed to the continuous exposure of the string outside the urethra must be managed. This paper introduces a method to decrease the exposure time, and conducts a retrospective study to verify its efficiency and safety.

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. We present a technique for determining whether to ligate or preserve accessory arteries in donor kidneys before implantation. .

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Objectives: Although mycophenolate mofetil-induced (MMF) effectively improves long-term graft survival, the gastrointestinal (GI) side effects due to MMF-induced GI barrier damage limit its use in clinic. Keratinocyte growth factor (KGF) plays a crucial role in the intestinal protection and repair process. This study is designed to investigate the protective effect of KGF on MMF-induced intestinal mucosal barrier disruption and the potential mechanism.

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  • Burn injuries disrupt the intestinal barrier, leading to inflammation and increased permeability, which triggers the release of pro-inflammatory cytokines like IL-17A and TNF-α.
  • * Neutralizing IL-17A significantly reduces intestinal damage and inflammation, helping to preserve the barrier function and lower cytokine levels.
  • * The study identifies IL-17AVγ4 T cells as a key source of IL-17A in the intestines following burn injury, underscoring the importance of targeting this pathway for potential therapeutic strategies.
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Objective: To introduce our hybrid technique using an endo-Satinsky clamp and in situ cold perfusion for right-sided retroperitoneoscopic donor nephrectomy (RDN) and to investigate efficacy and safety compared with those standard right-sided RDN.

Methods: This retrospective study included 16 transplant donors who underwent right-sided RDN from January 2016 to January 2018. Donors received either hybrid RDN (n = 6) or standard RDN (n = 10).

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Interstitial cystitis (IC) is a heterogeneous syndrome with unknown etiology, and microRNAs (miRs) were found to be involved in IC. In our study, we aim to explore the role of miR-132 in the inflammatory response and detrusor fibrosis in IC through the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway in rat models. A rat model of IC was established and treated with the miR-132 mimic, miR-132 inhibitor, and/or JAK-STAT signaling pathway inhibitor AG490.

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UGT2B15 (uridine diphosphate-glucuronosyltransferase 2B15) catalyzes the conversion of lipophilic C19 steroid androgens such as dihydrotestosterone (DHT) into water-soluble metabolites that can be excreted. Studies of the association between the gene D85Y polymorphism and prostate cancer have yielded contradictory results. We therefore systematically searched in the PubMed, EMBASE, Science Direct/Elsevier, CNKI, and Cochrane Library databases, and identified six relevant studies with which to perform a meta-analysis of the relation between D85Y polymorphism and prostate cancer risk.

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Effective doctor-patient communication is essential for establishing a successful doctor-patient relationship and implementing high-quality health care. In this study, a novel urinary system-simulating physical model was designed and fabricated, and its content validity for improving doctor-patient communication was examined by conducting a randomized controlled trial in which this system was compared with photographs. A total of 240 inpatients were randomly selected and assigned to six doctors for treatment.

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Background: Simulators have been widely used to train operational skills in urology, how to improve its effectiveness deserves further investigation. In this paper, we evaluated training using a novel transparent anatomic simulator, an opaque model or no simulator training, with regard to post-training ureteroscopy and cystoscopy proficiency.

Methods: Anatomically correct transparent and non-transparent endourological simulators were fabricated.

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Objective: This randomized controlled study compared a novel transparent urinary tract simulator with the traditional opaque urinary tract simulator as an aid for efficiently teaching urological surgical procedures.

Methods: Senior medical students were tested on their understanding of urological theory before and after lectures concerning urinary system disease. The students received operative training using the transparent urinary tract simulator (experimental group, n = 80) or the J3311 opaque plastic urinary tract simulator (control, n = 80), specifically in catheterization and retrograde double-J stent implantation.

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Objective: To develop a simple minimally invasive method for ureteral stent removal that does not require cystoscopy or fluoroscopic guidance.

Materials And Methods: We developed a novel ureteral stent comprising the main body of a stent and an iron oxide-coated net that was woven of processed polyester sutures. The ureteral stent was retrieved by a magnetic retrieval catheter with small hooks on the neck surface.

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This article describes a novel Multifunctional and Transparent Urinary System Model (MTUSM), which can be applied to anatomy teaching, operational training of clinical skills as well as simulated experiments in vitro. This model covers kidneys, ureters, bladder, prostate, male and female urethra, bracket and pedestal, etc. Based on human anatomy structure and parameters, MTUSM consists of two transparent layers i.

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A distortion correction method for a fisheye image is proposed based on the virtual small-field (SF) camera. The correction experiment is carried out, and a comparison is made between the proposed method and the conventional global correction method. From the experimental results, the corrected image by this method satisfies the law of perspective projection, and the image looks as if it was captured by an SF camera with the optical axis pointing at the corrected center.

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