The causality between use of glucocorticoids and risk of pancreatitis: a Mendelian randomization study.

Background And Aim: To date, the association between glucocorticoid use and the risk of pancreatitis remains controversial. The aim of this study was the investigation of this possible relationship.

Methods: We carried out a two-sample Mendelian randomization (MR) analysis using GWAS data from European ancestry, East Asian descendants and the FinnGen Biobank Consortium to evaluate this potential causal relationship.

Research on Leak Detection of Low-Pressure Gas Pipelines in Buildings Based on Improved Variational Mode Decomposition and Robust Kalman Filtering.

Aiming at the complex characteristics of negative pressure waves in low-pressure pipelines inside of buildings, we proposed an estimation method of pressure fluctuation trends based on the robust Kalman filter and the improved VMD, which can be used for leakage detection. The reconstructed baseline signal can accurately describe the fluctuation trend of the negative pressure wave after the pressure drop, and quantitatively express the characteristic difference between the leakage condition and the gas usage condition. The robust Kalman filter was used to estimate the pressure fluctuations.

Ultrathin Ni-Fe MOF Nanosheets: Efficient and Durable Water Oxidation at High Current Densities.

Efficient, durable, and economical electrocatalysts are crucial for advancing energy technology by facilitating the oxygen evolution reaction (OER). Here, ultrathin Ni-Fe metal-organic skeleton (MOF) nanosheets were created in situ on nickel foam (NiFe-UMNs/NF). The catalyst exhibited excellent OER catalytical abilities, with only 269 mV overpotentials at 250 mA cm.

Genome-Wide Identification and Characterization of Homeobox Transcription Factors in var. Causing Sugarcane Twisted Leaf Disease.

A homeobox transcription factor is a conserved transcription factor, ubiquitous in eukaryotes, that regulates the tissue formation of structure, cell differentiation, proliferation, and cancer. This study identified the homeobox transcription factor family and its distribution in var. at the whole genome level.

The Necroptotic Process-Related Signature Predicts Immune Infiltration and Drug Sensitivity in Kidney Renal Papillary Cell Carcinoma.

Background: It remains controversial whether the current subtypes of kidney renal papillary cell carcinoma (KIRP) can be used to predict the prognosis independently.

Objective: This observational study aimed to identify a risk signature based on necroptotic pro-cess-related genes (NPRGs) in KIRP.

Methods: In the training cohort, LASSO regression was applied to construct the risk signature from 158 NPRGs, followed by the analysis of Overall Survival (OS) using the Kaplan-Meier method.

The mediating role of psychological capital on the relationship between authentic leadership and innovative behaviour among Chinese nurses.

Aim: To explore the mediating role of psychological capital between authentic leadership and innovative behaviour among Chinese nurses.

Design: A cross-sectional study.

Methods: In December 2021, online surveys were delivered among nurses from 37 hospitals in Anhui Province by convenience sampling approach.

SIRT6-mediated Runx2 downregulation inhibits osteogenic differentiation of human aortic valve interstitial cells in calcific aortic valve disease.

Calcific aortic valve disease (CAVD) is a progressive cardiovascular disorder involving multiple pathogenesis. Effective pharmacological therapies are currently unavailable. Sirtuin6 (SIRT6) has been shown to protect against aortic valve calcification in CAVD.

Novel Perovskite Structured NdBaCoNiMnO as Highly Efficient Catalyst for Oxygen Electrode in Solid Oxide Electrochemical Cells.

Developing catalytic materials with highly efficient oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) is essential for lower-temperature solid oxide fuel cell (SOFC) and electrolysis cell (SOEC) technologies. In this work, a novel triple perovskite material, NdBaCoNiMnO, has been developed and employed as a catalyst for both ORR and OER in SOFC and SOEC operations at relatively lower temperatures, showing a low polarization resistance of 0.327 Ω cm, high-power output of SOFC up to 773 mW cm at 650 °C, and a high current density of 1.

The mediating role of psychological capital on the relationship between authentic leadership and nurses' caring behavior: a cross-sectional study.

Background: Caring behavior among nurses would have an impact on patient outcomes. External organizational job resources and personal internal psychological resources are correlated to nurses' caring behavior. Authentic leadership and psychological capital were shown to be correlated with nurses' caring behavior in previous studies.

Enhanced Proton Transport of β″-AlO Modified by LiAlO as a High-Performance Electrolyte for a Low-Temperature Solid Oxide Fuel Cell and an Electrolyzer.

β-AlO has been proven as a fast ionic conductor in solid batteries due to its unique structure. In this work, β-AlO was further modified by LiAlO and employed as the electrolyte material for low-temperature solid oxide fuel cells and electrolyzers, i.e.

Integration of Transcriptomic and Metabolomic Profiles Provides Insights into the Influence of Nitrogen on Secondary Metabolism in .

Nitrogen availability might play an essential role in plant diseases by enhancing fungal cell growth and influencing the expression of genes required for successful pathogenesis. Nitrogen availability could modulate secondary metabolic pathways as evidenced by the significant differential expression of several core genes involved in mycotoxin biosynthesis and genes encoding polyketide synthase/nonribosomal peptide synthetases, cytochrome P450 and carbohydrate-active enzymes in , grown on different nitrogen sources. A combined analysis was carried out on the transcript and metabolite profiles of regulatory metabolic processes and the virulence of grown on various nitrogen sources.

Cross-linked solid-liquid interfaces enable a fast proton transport in the aluminate heterostructure electrolyte.

Having a highly-conductive protonic electrolyte is an essential requirement of developing solid ceramic fuel cell (SCFC) operated below 600 °C. Proton transport in solid electrolyte structure occurs via a bulk conduction mechanism in conventional SCFC, which may not be so efficient; therefore we have developed a fast proton conducting NaAlO/LiAlO (NAO-LAO) heterostructure electrolyte, achieving the ionic conductivity of 0.23 S cm thanks to its rich cross-linked solid-liquid interfaces; the SCFC employing this new developed electrolyte showed a maximum power density of 844 mW cm at 550 °C, and the fuel cell could still operate at even lower temperatures down to 370 °C, although the output reduced to 90 mW cm.

Insights into the Origin of High Activity of NiP(0001) for Hydrogen Evolution Reaction.

Hydrogen evolution reaction (HER) is directly relevant to green hydrogen production from water splitting. Recently, a low-cost NiP material has been demonstrated experimentally and theoretically to exhibit excellent electrocatalytic activity toward HER. However, a fundamental understanding of the origin of NiP(0001) activity is still lacking.

BMAL1 Promotes Valvular Interstitial Cells' Osteogenic Differentiation through NF-κ B/AKT/MAPK Pathway.

Objectives: Calcific aortic valve disease (CAVD) is most common in the aging population and is without effective medical treatments. Brain and muscle ARNT-like 1 (BMAL1) is related to calcification. It has unique tissue-specific characteristics and plays different roles in different tissues' calcification processes.

Fibrillin-1 mutation contributes to Marfan syndrome by inhibiting Cav1.2-mediated cell proliferation in vascular smooth muscle cells.

Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutation in fibrillin-1 (FBN1). However, the molecular mechanism underlying MFS remains poorly understood. The study aimed to explore how the L-type calcium channel (Ca1.

Synthesis and characterization of Craig-type antiaromatic species with [4 + 2] π electrons.

Antiaromaticity is extended from aromaticity as a complement to describe the unsaturated cyclic molecules with antiaromatic destabilization. To prepare antiaromatic species is a particularly challenging goal in synthetic chemistry because of the thermodynamic instability of such molecules. Among that, both Hückel and Möbius antiaromatic species have been reported, whereas the Craig one has not been realized to date.

Designing High Interfacial Conduction beyond Bulk via Engineering the Semiconductor-Ionic Heterostructure CeO/BaZrYO for Superior Proton Conductive Fuel Cell and Water Electrolysis Applications.

Proton ceramic fuel cells (PCFCs) are an emerging clean energy technology; however, a key challenge persists in improving the electrolyte proton conductivity, e.g., around 10-10 S cm at 600 °C for the well-known BaZrYO (BZY), that is far below the required 0.

Insights into reaction mechanisms of ethanol electrooxidation at the Pt/Au(111) interfaces using density functional theory.

Understanding ethanol electrooxidation reaction kinetics is fundamental to the development of direct ethanol fuel cells. The utilization of binary PtAu catalysts has been reported recently as an effective strategy to enhance ethanol electrocatalytic oxidation; however, the catalytic reaction mechanisms are still unclear. In this work, we systematically studied the ethanol electrooxidation reaction mechanisms on Pt/Au(111) model surfaces at an atomic level through high level density functional theory (DFT) calculations; particularly the flat (111) terrace and the stepped (111) × (110) and (111) × (100) interfaces with diverse surface atomic arrangements were considered, respectively.

Integrated Analysis of Genomic and Transcriptomic Profiles Identified the Role of GTP Binding Protein-4 (GTPBP4) in Breast Cancer.

To explore the significance of GTP-binding protein 4 (GTPBP4) in breast cancer. Firstly, GTPBP4 expression analysis was performed in TIMER and UALCAN databases. Subsequently, the TCGA cohort and multiple Gene Expression Omnibus Cohorts were used as validation for GTPBP4 expression.

Effects of Monochromatic Blue Light on Reducing the Adverse Impact of Induced Cyclic Chronic Heat Stress during the Thermal Manipulation of Broiler Embryos.

Objective: The aim was to detect effects of blue light on reducing the adverse effect of heat stress in thermal manipulation (TM) of broiler embryos by subjecting embryos to heat stress during incubation development.

Methods: Eggs were assigned to four treatments in which the TM (thermal manipulation) was exposed to 40°C for 4 h daily during five successive days, if TM was operated. The treatments were (1) normal temperature with white lighting group (37°C+W), (2) normal temperature with blue lighting group (37°C+B), (3) thermal manipulation with white lighting group (40°C+W), and (4) thermal manipulation with blue lighting group (40°C+B).

High CO-Tolerant Ru-Based Catalysts by Constructing an Oxide Blocking Layer.

CO poisoning of Pt-group metal catalysts is a long-standing problem, particularly for hydrogen oxidation reaction in proton exchange membrane fuel cells. Here, we report a catalyst of Ru oxide-coated Ru supported on TiO (Ru@RuO/TiO), which can tolerate 1-3% CO, enhanced by about 2 orders of magnitude over the classic PtRu/C catalyst, for hydrogen electrooxidation in a rotating disk electrode test. This catalyst can work stably in 1% CO/H for 50 h.

Identification of MICALL2 as a Novel Prognostic Biomarker Correlating with Inflammation and T Cell Exhaustion of Kidney Renal Clear Cell Carcinoma.

The interplay of inflammation and immunity affects all stages from tumorigenesis to progression, and even tumor response to therapy. A growing interest has been attracted from the biological function of MICALL2 to its effects on tumor progression. This study was designed to verify whether MICALL2 could be a prognostic biomarker to predict kidney renal clear cell carcinoma (KIRC) progression, inflammation, and immune infiltration within tumor microenvironment (TME).

Dkk3/REIC Deficiency Impairs Spermiation, Sperm Fibrous Sheath Integrity and the Sperm Motility of Mice.

The role of (), a Wnt-signaling inhibitor, in male reproductive physiology remains unknown thus far. To explore the functional details of in the male reproductive process, we studied the knock-out (KO) mouse model. By examining testicular sections and investigating the sperm characteristics (count, vitality and motility) and ultrastructure, we compared the reproductive features between -KO and wild-type (WT) male mice.

A Novel Prognostic Predictor of Immune Microenvironment and Therapeutic Response in Kidney Renal Clear Cell Carcinoma based on Necroptosis-related Gene Signature.

Necroptosis, a cell death of caspase-independence, plays a pivotal role in cancer biological regulation. Although necroptosis is closely associated with oncogenesis, cancer metastasis, and immunity, there remains a lack of studies determining the role of necroptosis-related genes (NRGs) in the highly immunogenic cancer type, kidney renal clear cell carcinoma (KIRC). The information of clinicopathology and transcriptome was extracted from TCGA database.