Fisetin Alleviates d-Galactose-Induced Senescence in C2C12 Myoblasts: Metabolic and Gene Regulatory Mechanisms.

Skeletal muscle aging poses a major threat to the health and quality of life of elderly individuals. Fisetin, a natural polyphenolic compound, exhibits various biological activities; however, its role in preventing skeletal muscle cell aging is still unclear. This study aimed to elucidate the effects of fisetin on skeletal muscle aging using a d-galactose-induced C2C12 myoblast senescence model.

Summary of the best evidence for prehabilitation management of patients with non-small cell lung cancer.

Objective: This study adopts an evidence-based methodology to establish a comprehensive theory foundation for preoperative prehabilitation management in non-small cell lung cancer (NSCLC) patients.

Methods: A systematic literature review linked to prehabilitation management for NSCLC patients was conducted, utilizing reputable databases such as UpToDate, BMJ Best Practice, UK NICE, SIGN, GIN, Joanna Briggs Institute Library, Cochrane Library, Web of Science, Embase, OVID evidence-based database, PubMed, Chinese Wanfang database, CNKI, CBM, ATS, BTS, AACVPR, and EACTS. The search encompassed articles, including clinical decision-making, guidelines, evidence summaries, expert consensuses, and systematic reviews, from the inception of databases up to March 31st, 2023.

Global myocardial work in coronary artery disease patients without regional wall motion abnormality: Correlation with Gensini-score.

Background: Early detection of coronary atherosclerotic diseases (CAD) without regional wall motion abnormality (RWMA) is important for improving the outcome of cardiovascular events. Global myocardial work (GMW), including global myocardial work index (GWI), global constructive work (GCW), global wasted work (GWW), and global myocardial work efficiency (GWE), offer comprehensive quantitative assessment of myocardial function in CAD.

Hypothesis: We hypothesized that GMW could provide incremental value in detecting CAD without RWMA.

An effective fingerprint orientation field estimation method using differential values of grayscale intensity.

Fingerprint orientation field (OF) estimation is important for basic fingerprint image processing and impacts the accuracy of fingerprint image enhancements, such as Gabor filters. In this article, we introduce an OF estimation algorithm based on differential values of grayscale intensity and examine the accuracy and reliability of the proposed algorithm by applying it to fingerprint images processed using Gaussian blurring and the Gaussian white noise process. The experimental results indicate that the OF estimation reliability of the proposed algorithm is higher than the gradient-based method and the power spectral density (PSD) based method in low quality fingerprints.

The Enhanced Thermal Stability of (MgNi)TiO Dielectric Ceramics Modified by a Multi-Phase Method.

The thermal stability of (MgNi)TiO dielectric ceramics has been improved by mixing with CaTiO phases owing to higher positive temperature coefficients. The pure (MgNi)TiO and the mixture phase systems of CaTiO-modified (MgNi)TiO were verified by XRD diffraction patterns to ensure the crystallite of different phases. The microstructures of the CaTiO-modified (MgNi)TiO were observed by SEM and EDS to investigate the relation between element ratios and grains.

Spider venom-derived peptide JZTX-14 prevents migration and invasion of breast cancer cells inhibition of sodium channels.

Nav1.5 channel is crucial for the proliferation and migration of breast cancer cells. In this study, we investigated the anticancer effect of JZTX-14, a natural peptide considered an effective antagonist of Nav1.

Experimental results and mathematical formulation of non-spinning stone-skipping process.

Following a previously published paper in studying stone-skipping processes, detailed experimental figures are revealed in this paper. A mathematical model is also provided to explain the observed phenomena and measured data. The model separates the skipping process into several stages.

Clinical utility of a serum biomarker panel in distinguishing prostate cancer from benign prostate hyperplasia.

Prostate-specific antigen (PSA) screening for prostate cancer (PCa) is limited by the lack of specificity but is further complicated in the benign prostatic hyperplasia (BPH) population which also exhibit elevated PSA, representing a clear unmet need to distinguish BPH from PCa. Herein, we evaluated the utility of FLNA IP-MRM, age, and prostate volume to stratify men with BPH from those with PCa. Diagnostic performance of the biomarker panel was better than PSA alone in discriminating patients with negative biopsy from those with PCa, as well as those who have had multiple prior biopsies (AUC 0.

The Functional Role of Voltage-Gated Sodium Channel Nav1.5 in Metastatic Breast Cancer.

Voltage-gated sodium channels (VGSCs), which are abnormally expressed in various types of cancers such as breast cancer, prostate cancer, lung cancer, and cervical cancer, are involved in the metastatic process of invasion and migration. Nav1.5 is a pore-forming α subunit of VGSC encoded by .

Post-Left Atrium Space Index in Fetuses With Total Anomalous Pulmonary Venous Connection and Other Congenital Heart Diseases.

Objectives: We aimed to explore the value of the post-left atrium space (PLAS) index in the diagnosis of total anomalous pulmonary venous connection (TAPVC) and the effect of other congenital heart diseases on the PLAS index in the fetus.

Methods: The PLAS index of 69 fetuses with TAPVC was analyzed retrospectively. Approximately 252 healthy fetuses were randomly selected as controls, and 110 cases of intracardiac malformations were randomly selected for comparison.

Recent progress in understanding 2019 novel coronavirus (SARS-CoV-2) associated with human respiratory disease: detection, mechanisms and treatment.

Viral respiratory diseases such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) always pose a severe threat to people. First identified in late December 2019, a novel coronavirus (2019-nCoV; SARS-CoV-2) has affected many provinces in China and multiple countries worldwide. The viral outbreak has aroused panic and a public-health emergency around the world, and the number of infections continues to rise.

Association between magnetic resonance imaging of carotid artery and coronary stenosis detected by computed tomography angiography.

Objective: To investigate the correlation between carotid artery stenosis (CAS) measured by magnetic resonance imaging (MRI) and the coronary stenosis (CS) determined by computed tomography angiography (CTA).

Methods: In this prospective study, 42 subjects diagnosed with coronary artery disease (CAD) underwent MRI and CTA examinations. The severity degree and number of CAS, the score, detection rate and type of carotid plaque, and also the severity degree and number of CS were assessed.

Left and right ventricular function detection and myocardial deformation analysis in heart transplant patients with long-time follow-ups.

Objective: We try to investigate whether the values of longitudinal strain present differences between the left and right ventricles in long-time follow-ups after heart transplantation (HTx) with dynamic changes in function.

Methods And Results: Follow-up transthoracic echocardiography was performed in 1- and 3-month and 1- and 5-year follow-ups in 50 "healthy" HTx patients and compared with 26 control subjects. The left ventricle with preserved ejection fraction evaluated by biplane Simpson (control group [CG] vs HT; P > .

Biomechanical characteristics of isolated carotid atherosclerotic plaques assessed by ultrasonography.

Background: The aim of this study was to assess the biomechanical characteristics of carotid atherosclerotic plaques using intima-media thickness (IMT) automatic tracking combined with acoustic densitometry (AD) imaging, and to elucidate the relationship between biomechanical characteristics and inflammatory activity of corresponding plaques evaluated by 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT).

Methods: Sixty-one patients with isolated carotid atherosclerotic plaques underwent conventional carotid ultrasonography, IMT automatic tracking, and acoustic densitometry (AD) imaging. Following these assessments, patients received an 18F-FDG PET/CT scan within 24 hours.

Left ventricular dyssynchrony in coronary artery disease patients without regional wall-motion abnormality: Correlation with Gensini score.

Objectives: Our study investigated left ventricular dyssynchrony (LVD) in coronary artery disease (CAD) patients without regional wall-motion abnormality (RWMA) by three-dimensional echocardiography (3-DE) and explored the relationship between LVD and severity of CAD as assessed by the Gensini score (GS).

Methods: Sixty-one patients with a confirmed diagnosis of CAD by coronary angiography (CAG) were enrolled. We quantified LVD parameters, including the left ventricular segments (16, 12, and 6) standard deviation of the time to minimum systolic volume (TmsvSD-16, TmsvSD-12, and TmsvSD-6) and the systolic dyssynchrony index in regions 16, 12, and 6 (16R-SDI, 12R-SDI, 6R-SDI) using 3-DE.

Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities.

Spider venoms are known to contain proteins and polypeptides that perform various functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and hemagglutinic activities. Currently, several classes of natural molecules from spider venoms are potential sources of chemotherapeutics against tumor cells. Some of the spider peptide toxins produce lethal effects on tumor cells by regulating the cell cycle, activating caspase pathway or inactivating mitochondria.

Half-Metallic Property Induced by Double Exchange Interaction in the Double Perovskite BiO ( = Transitional Metal) via First-Principles Calculations.

In this paper, we identify three possible candidate series of half-metals (HM) from Bi-based double perovskites Bi'O (' = transition metal ions) through calculations utilizing the density functional theory (DFT) and full-structural optimization, in which the generalized gradient approximation (GGA) and the strong correlation effect (GGA + ) are considered. After observing the candidate materials under four types of magnetic states, i.e.

Psychometric Properties and Factor Structure of the Chinese Version of the Hospital Anxiety and Depression Scale in People Living With HIV.

The population of people living with HIV (PLWH) is growing in number and usually results in mental health problems that impact their quality of life. Therefore, valid instruments and screening methods for psychological disorders are of great significance. The Hospital Anxiety and Depression Scale (HADS) reveals good psychometric properties, but shows ambiguous results in factor structure.

Diablo ubiquitination analysis by sandwich immunoassay.

Ubiquitin plays an essential role in modulating protein function, and deregulation of the ubiquitin system leads to the development of a variety of human diseases. E3 Ubiquitin ligases that mediate ubiquitination and degradation of caspases prevent apoptosis, and as such belong to the family of inhibitors of apoptosis proteins (IAPs). Diablo is a substrate of IAPs but also a negative regulator of IAPs in apoptotic pathway as it blocks the interaction between IAPs and caspases.

A Dynamic Model for Predicting Outcome in Patients with HBV Related Acute-On-Chronic Liver Failure.

Introduction And Aim: Accurately predicting the prognosis of individual patient is crucial in the management of ACLF. We aimed to establish a specific prognostic model for HBV-related ACLF patients treated with nucleoside analog (NA).

Material And Methods: We prospectively collected 205 ACLF cases diagnosed according to the APASL criteria.

Oxic Fe(III) reduction could have generated Fe(II) in the photic zone of Precambrian seawater.

Many marine Precambrian iron formations (IF) record deep anoxic seawater enriched in Fe(II) (i.e. ferruginous) overlain by mildly oxygenated surface water.

Human CCDC47 sandwich immunoassay development with electrochemiluminescence technology.

Coiled-Coil Domain Containing 47 (CCDC47) is an endoplasmic reticulum (ER) transmembrane protein involved in calcium signaling through utilization of its calcium binding-acidic luminal domain. CCDC47 also interacts with ERAD (endoplasmic reticulum-associated degradation) complex and is involved in ER stress relief. In this report, we developed human CCDC47 monoclonal antibodies and a sandwich immunoassay for CCDC47 measurement in biological matrices.

Leiomyosarcoma of the splenic vein: A case report.

Leiomyosarcomas (LMSs) originating from the wall of blood vessels are aggressive and rare neoplasms. The current study describes a case of a 52-year-old man who presented with intermittent abdominal pain without weight loss or diarrhea. Computed tomography of the abdomen identified a 4-cm, solid, heterogeneous tumor in the tail of the pancreas, while a hypodense lesion was also noted in the right hepatic lobe.