Significant increase of the photoresponse range and conductivity for a chalcogenide semiconductor by viologen coating through charge transfer.

Widening the photoresponse range while enhancing the electrical properties of semiconductors could reduce the complexity and cost of photodetectors or increase the power conversion efficiency of solar cells. Surface doping through charge transfer with organic species is one of the most effective and widely used approaches to achieve this aim. It usually features easier preparation over other doping methods but is still limited by the low physicochemical stability and high cost of the used organic species or low improvement of electrical properties.

Cs Zn P S I : the Largest Birefringence in Chalcohalide Achieved by Highly Polarizable Nonlinear Optical Functional Motifs.

Chalcohalides not only keep the balance between the nonlinear optical (NLO) coefficient and wide band gap, but also provide a promising solution to achieve sufficient birefringence for phase-matching ability in NLO crystals. In this study, a novel chalcohalide, Cs Zn P S I (1) is successfully synthesized, by incorporating the highly electropositive Cs and the large electronegative I element into the zinc thiophosphate. Its 3D open framework features an edge-shared by distorted [ZnS ], ethanol-like [P S ], and unusual [ZnS I ] polyhedrons, which is inconsistent with the soft-hard-acids-bases theory.

Breaking the bottleneck of simultaneously wide band gap and large nonlinear optical coefficient by a "pore reconstruction" strategy in a salt-inclusion chalcogenide.

The template-based design of the crystal structure is a direct and highly efficient method to achieve optimal nonlinear optical (NLO, meaning second-order NLO) performances. The structural flexibility of porous salt-inclusion chalcogenides (SICs) provides an alternative platform for modulating the enlargement of the band gap (that is generally positive with laser-induced damage threshold) and second harmonic generation (SHG) response simultaneously. By applying the "pore reconstruction" strategy to SIC [KCl][MnGaS] (1), a new derivative KRb[KCl][LiMnGaS] (2) is successfully isolated, which unusually features a heterologous nanopore framework with inner diameters of 8.

Open honeycomb frameworks of sulphides AHgGaS (A = Rb, Cs) exhibiting infrared nonlinear optical properties.

A crystal structure with a diamond-like anionic framework belongs to a non-centrosymmetric macrostructure due to the aligned arrangement of tetrahedral units, meeting the premise of second-order nonlinear optical (NLO) materials. Herein, two new Hg-based sulphides, namely RbHgGaS (1) and CsHgGaS (2), which are isostructural and crystallise in the trigonal space group 3, are successfully isolated in sealed silica tubes by a solid-state reaction. The features of their three-dimensional open honeycomb frameworks are attributed to the parallel alignment of tetrahedral MS (M is disordered by 0.

[K PbX][Ga S ] (X = Cl, Br, I): The First Lead-Containing Cationic Moieties with Ultrahigh Second-Harmonic Generation and Band Gaps Exceeding the Criterion of 2.33 eV.

In contrast to anionic group theory of nonlinear optical (NLO) materials that second-harmonic generation (SHG) responses mainly originate from anionic groups, structural regulation on the cationic groups of salt-inclusion chalcogenides (SICs) is performed to make them also contribute to the NLO effects. Herein, the stereochemically active lone-electron-pair Pb cation is first introduced to the cationic groups of NLO SICs, and the resultant [K PbX][Ga S ] (X = Cl, Br, I) are isolated via solid-state method. The features of their three-dimensional structures comprise highly oriented [Ga S ] and [K PbX] frameworks derived from AgGaS , which display the largest phase-matching SHG intensities (2.

Advances in research on 3C-like protease (3CL) inhibitors against SARS-CoV-2 since 2020.

COVID-19 caused by SARS-CoV-2 in late 2019 is still threatening global human health. Although some vaccines and drugs are available in the market, controlling the spread of the SARS-CoV-2 virus remains a huge challenge. 3C-like protease (3CL) is a highly conserved key protease for SARS-CoV-2 replication, and no relevant homologous protein with a similar cleavage site to 3CL has been identified in humans, highlighting that development of 3CL inhibitors exhibits great promise for treatment of COVID-19.

AAgGaSe (A = Rb, Cs): second-harmonic generation responses realized through the parallel arrangement of AgSe and GaSe tetrahedrons.

Two new quaternary selenides AAgGaSe, (A = Rb, 1; Cs, 2) were synthesised solid-state reaction in sealed silica tubes. Compounds 1 and 2 crystallised in the monoclinic space group (no. 8) and their three-dimensional [AgGaSe] anionic frameworks were comprised of AgSe and GaSe tetrahedrons.

Effect of mutations across reverse transcriptase region on HBV replication and progression of liver diseases in Chinese patients.

It was known that mutations in the RT region were mainly related to nucleot(s)ide analogs resistance. Increasing studies indicated that RT mutations were related to advanced liver diseases (ALD) and had effects on HBV replication, but the distribution characteristics of mutations across RT region in the development of liver diseases and the effect of RT mutations on HBV replication were not fully clarified. HBV RT region was direct-sequenced in 1473 chronic HBV-infected patients.

Photocurrent, humidity sensitivity and proton conductivity properties of a new sulfide semiconductor CsCuS.

Copper chalcogenides have drawn considerable attention due to their prominent semiconducting properties. A new Cu-containing semiconductor, namely, CsCuS (1), was obtained by a halide salt flux method. Its structure featured 1D infinite ∞1[CuS] chains, where the polysulfide anion S was relatively rare in Cu chalcogenides.

Optimizing the Nonlinear Optical Performance of an A-N-M-Q (A: Alkali Metal; N: Metal; M: Main Group Metal; Q: Chalcogen) System.

Exploring new infrared nonlinear optical (IR NLO) materials with superior overall properties is scientifically and technically important. However, large second-order harmonic generation (SHG) efficiencies and high laser-induced damage thresholds (LIDT) are incompatible, which makes realizing this goal a challenge. The IR NLO performance of an A-N-M-Q (Q: chalcogen) system was optimized by simultaneously modulating A/(M + N) and M/N ratios (A: alkali metal; N, M: tetra-coordinated metals), and SHG-LIDT balance was achieved.

Balanced infrared nonlinear optical performance achieved by modulating the covalency and ionicity distributions in the electron localization function map.

The nonlinear optical (NLO) efficiency () and laser-induced damage threshold (LIDT) of a material are mainly determined by their covalency and ionicity, respectively, the incompatibility between which makes balancing the and LIDT challenging in an IR NLO material. The topological feature (fractal dimension) of the electron localization function (ELF) map (distribution of covalency and ionicity) was evaluated for a series of NLO materials, and, phenomenologically, the fine mixing of covalency and ionicity will benefit a balanced and LIDT. Chemical bonds with different interaction strengths were introduced simultaneously to mix the covalency and iconicity finely, and three new IR NLO sulfides, ABaLiGaS (A = K, 1; Rb, 2; Cs, 3), were obtained.

miR-200b-3p mitigates oxaliplatin resistance via targeting TUBB3 in colorectal cancer.

Background: Numerous abnormally expressed miRs have been reported involved in oxaliplatin (L-OHP) resistance of colorectal cancer (CRC). The present study aimed to investigate whether miR-200b-3p could regulate L-OHP resistance via targeting TUBB3 in CRC cells.

Methods: L-OHP resistant HT29 and HCT116 cells were exposed to escalating concentrations of L-OHP up to 30 μm.

[Effects of aqueous extracts of gecko on stemness of hepatocellular carcinoma].

To explore the effects and mechanism of aqueous extracts of gecko on cancer stem cells properties of hepatocellular carcinoma. In vitro, MTT assay was used to detect the cells growth in Huh7 and Hep3B. Spheroid-forming assay and flow cytometry were performed to observe the the stemness of Huh7 and Hep3B cells.

[Clinical application of the modified laryngeal mask airway for endobronchial ultrasound-guided transbronchial needle aspiration biopsy].

Objective: To observe the clinical application of the modified laryngeal mask airway for endobronchial ultrasound-guided transbronchial needle aspiration biopsy.

Method: By the induction of the general anesthesia, 42 patients undergoing endobronchial ultrasound-guided transbronchial needle aspiration biopsy between september 2012 and may 2013 were managed with the modified laryngeal mask airway. The group consisted of 42 male patients aged 56 years to 67 years, with a median age of 61.

Adsorption of carbon dioxide from gas streams via mesoporous spherical-silica particles.

A relatively new mesoporous silica sorbent for environmental protection applications (i.e., mesoporous spherical-silica particles [MSPs]), was modified by N-[3-(trimethoxysilyl)propyl]ethylenediamine (EDA) solution and was tested for its potential in the separation of carbon dioxide (CO2) from flue gas.