Publications by authors named "Wendy Sebetka"
Electrodiagnostic testing in acute facial palsy: Outcomes and comparison of methods.
Laryngoscope Investig Otolaryngol
October 2020
Article Synopsis
- The study examines the correlation between different electrodiagnostic methods in assessing acute facial paralysis among 106 patients at a tertiary care center from 2008 to 2017.
- Both nasolabial fold (NLF) and nasalis muscle (NM) methods showed a strong correlation in measuring facial nerve degeneration, with 80% of patients diagnosed with significant degeneration using both methods.
- The absence of muscle unit potentials (MUPs) on electromyography (EMG) proved to be a reliable indicator of severe nerve degeneration, making it a useful predictor for deciding on surgical intervention.
A postsynaptic dysfunction of the neuromuscular junction has been reported in patients with alpha-dystroglycanopathy associated with mutations in guanosine diphosphate (GDP)-mannose pyrophosphorylase B gene (GMPPB), some of whom benefit from symptomatic treatment. In this study, we determine the frequency of myasthenic and fatigue symptoms and neuromuscular junction transmission defects in a fukutin-related protein (FKRP)-predominant alpha-dystroglycanopathy cohort. Thirty-one patients with alpha-dystroglycanopathies due to mutations in FKRP (n = 25), GMPPB (n = 4), POMGNT1 (n = 1), and POMT2 (n = 1) completed a six-question modified questionnaire for myasthenic symptoms and the PROMIS Short Form v1.
View Article and Find Full Text PDF