Evaluation of the Effect of Tofacitinib on the Pharmacokinetics of Oral Contraceptive Steroids in Healthy Female Volunteers.

Tofacitinib is an oral Janus kinase inhibitor. Tofacitinib metabolism is primarily mediated by cytochrome P450 3A4. This phase 1 randomized, open-label, 2-way crossover study (NCT01137708) evaluated the effect of tofacitinib 30 mg twice daily on the single-dose pharmacokinetics of combination oral contraceptives ethinylestradiol (EE) and levonorgestrel (LN).

Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans.

The transient receptor potential (subfamily M, member 8; TRPM8) is a nonselective cation channel localized in primary sensory neurons, and is a candidate for cold thermosensing, mediation of cold pain, and bladder overactivity. Studies with TRPM8 knockout mice and selective TRPM8 channel blockers demonstrate a lack of cold sensitivity and reduced cold pain in various rodent models. Furthermore, TRPM8 blockers significantly lower body temperature.

Pharmacokinetic interactions of maraviroc with darunavir-ritonavir, etravirine, and etravirine-darunavir-ritonavir in healthy volunteers: results of two drug interaction trials.

The effects of darunavir-ritonavir at 600 and 100 mg twice daily (b.i.d.

Multi-detector row CT pulmonary angiography: comparison of standard-dose and simulated low-dose techniques.

Purpose: To compare standard-dose and simulated low-dose multi-detector row computed tomography (CT) pulmonary angiography.

Materials And Methods: The institutional review board approved the study protocol and waived patient informed consent because the study was based on existing data. Raw data from 21 CT scans obtained at 90 mAs (effective) in 11 women and 10 men aged 25-74 years (mean, 52 years) that showed at least one filling defect within a pulmonary artery were used to simulate CT pulmonary angiography with reduced radiation doses, at 60, 40, 20, and 10 mAs.