Publications by authors named "Wendy Osei-Bonsu"
Background: Pathogenic variants in SCN1B, the gene encoding voltage-gated sodium channel b1/b1B subunits are associated with a spectrum of epileptic disorders. This study describes a child with early myoclonic encephalopathy and a compound heterozygous variant in the SCN1B gene (p.Arg85Cys and c.
View Article and Find Full Text PDFArticle Synopsis
- Islet function is vital for maintaining normal blood sugar levels, but fetal and neonatal islets have different characteristics compared to adult ones, exhibiting more growth but less insulin response.
- The study focused on the interaction among various cell types in pancreatic islets and how these interactions influence β-cell development and maturation, combining genomic and epigenomic data from rats of different ages.
- A total of 4,489 genes were found to change in expression due to maturation, revealing important pathways related to islet function, along with significant alterations in histone modifications that affect gene regulation during islet development.