Publications by authors named "Wendy Limousin"
Article Synopsis
- The study aimed to evaluate the importance of liver biopsy in patients with unexplained elevated transaminases, following current clinical guidelines.
- A retrospective analysis of 87 patients revealed that 48% had minimal or normal liver tissue changes, while different injury patterns were identified in varying percentages: steatosis (21%), hepatitis (13%), vascular (8%), and biliary (1%).
- Ultimately, liver biopsy significantly impacted clinical management in 15% of cases, helping diagnose conditions like autoimmune hepatitis and metabolic dysfunction, but most patients showed little to no significant pathology.
Background & Aims: The "French Medicine Genomic program 2025" has been designed to give patients with cancers that are refractory to systemic treatments access to off-label therapies adapted to their specific genomic profile. Herein, we reported the results of this program in patients with advanced hepatocellular carcinoma (HCC) and hepato-cholangiocarcinoma (H-CCK).
Methods: In one center, all patients with HCC or H-CCK who progressed under atezolizumab/bevacizumab with available tumor frozen samples benefited from whole-genome/-exome and RNA sequencing.