Publications by authors named "Wendy Kreshpa"
Article Synopsis
- Apathy unawareness in mild cognitive impairment (MCI) is linked to differences between caregiver and patient assessments, potentially predicting progression to Alzheimer's dementia.
- Researchers studied 28 MCI patients, using the Apathy Evaluation Scale to gauge apathy levels from both perspectives, and analyzed brain activity via PET scans.
- Findings revealed that greater discrepancies in assessments correlated with lower metabolism in specific brain regions, indicating that apathy unawareness is tied to early limbic system disruptions rather than traditional pathways associated with apathy.
Background: Neuronal pentraxin-2 (NPTX2), crucial for synaptic functioning, declines in cerebrospinal fluid (CSF) as cognition deteriorates. The variations of CSF NPTX2 across mild cognitive impairment (MCI) due to Alzheimer's disease (AD) and its association with brain metabolism remain elusive, albeit relevant for patient stratification and pathophysiological insights.
Methods: We retrospectively analyzed 49 MCI-AD patients grouped by time until dementia (EMCI, n = 34 progressing within 2 years; LMCI, n = 15 progressing later/stable at follow-up).
Background: Pisa syndrome (PS) is a trunk postural abnormality in Parkinson's disease (PD). Its pathophysiology is still debated: peripheral and central mechanisms have been hypothesized.
Objective: To investigate the role of nigrostriatal dopaminergic deafferentation and of brain metabolism impairment in the onset PS in PD patients.