Publications by authors named "Wendt L"

Importance: The Pelvic Organ Prolapse Quantification (POP-Q) stages do not correlate with symptoms or characterize important prolapse subtypes.

Objectives: We hypothesize that clinically meaningful prolapse "phenotypes" utilizing POP-Q measurements can be defined. The primary aim was to define the phenotypes and their frequency.

View Article and Find Full Text PDF
Article Synopsis
  • Intracranial hemorrhage (ICH) is a serious risk for patients on oral anticoagulants, and there's a need for biomarkers to evaluate the effectiveness of reversal agents like activated prothrombin complex concentrate (aPCC).
  • A study was conducted in an emergency department with adult patients experiencing factor Xa inhibitor-related ICH to assess changes in thromboelastography (TEG) following aPCC reversal.
  • Results showed a significant decrease in TEG R-time shortly after aPCC administration, but it returned to baseline levels by 12 and 24 hours, suggesting TEG R-time could be a valuable biomarker to monitor anticoagulation effects in these patients.
View Article and Find Full Text PDF

Neutrophils, particularly low-density neutrophils (LDNs), are believed to contribute to acute COVID-19 severity. Here, we showed that neutrophilia can be detected acutely and even months after SARS-CoV-2 infection in patients and mice, while neutrophil depletion reduced disease severity in mice. A key factor in neutrophilia and severe disease in infected mice was traced to the chemokine CXCL12 secreted by bone marrow cells and unexpectedly, endothelial cells.

View Article and Find Full Text PDF
Article Synopsis
  • Viral factories (VFs) are membrane-less organelles where negative-sense RNA viruses, like Ebola, replicate and encapsidate their genomes.
  • Using advanced imaging techniques, researchers observed how viral nucleocapsids (NCs) change from loose formations to compact structures during the infection process.
  • The study found that as VFs mature, they become less spherical and more integrated with cellular components, which likely aids in the transportation of NCs for virus budding.
View Article and Find Full Text PDF

Our objective was to assess human immunodeficiency virus (HIV) knowledge and sexual behaviors in 294 perinatally HIV-infected youth aged 18 to 25 years from a psychosocial support group in Kampala using a self-administered survey. Seventy-nine percent reported an undetectable viral load, 9.5% detectable, and 12% did not know.

View Article and Find Full Text PDF
Article Synopsis
  • This study focused on understanding how common diagnostic uncertainty is when critically ill children are admitted to Pediatric Intensive Care Units (PICUs) and what factors contribute to it.
  • Researchers reviewed medical records from 882 pediatric patients across four hospitals to assess the presence of diagnostic uncertainty at admission and how it changed by the time of discharge.
  • Key findings indicated that 25.9% of patients showed diagnostic uncertainty upon PICU admission, with significant factors being the time of admission, illness severity, atypical symptoms, and discrepancies in diagnoses between different healthcare providers.
View Article and Find Full Text PDF

Background: Sarcoidosis is a multi-system disease frequently affecting the lungs. It is thought to be mediated by gene-environment interaction; for example, epidemiological data show organic aerosol exposure increases risk of pulmonary sarcoidosis.

Research Question: Does exposure to bioaerosol associate with worse lung disease in patients with pulmonary sarcoidosis?

Research Question: Using an observational, cohort study design, we measured residential exposure to fungal and bacterial cell wall material, β-(1,3)-D-glucan (BDG) and endotoxin, respectively, in healthy control subjects and those with pulmonary sarcoidosis.

View Article and Find Full Text PDF

Background: Postoperative delirium may be mediated by perioperative systemic- and neuro-inflammation. By inhibiting the pro-inflammatory actions of plasmin, tranexamic acid (TXA) may decrease postoperative delirium. To explore this hypothesis, we modified an ongoing randomised trial of TXA, adding measures of postoperative delirium, cognitive function, systemic cytokines, and astrocyte activation.

View Article and Find Full Text PDF
Article Synopsis
  • * It analyzed data from two groups of infants before and after the protocol's implementation, showing significant growth improvements (body weight and head circumference) in those born at 26-29 weeks.
  • * Results indicated that the protocol reduced the need for mechanical ventilation but did not increase the risk of health issues like hypertension or infections in extremely preterm infants.
View Article and Find Full Text PDF
Article Synopsis
  • Hypertension is common in patients with chronic kidney disease (CKD) and significantly affects their health, which is why lowering blood pressure (BP) is essential.
  • A study using NHANES data showed that while awareness and the use of BP medications among CKD patients increased from 2011 to 2020, overall blood pressure control remained unsatisfactory.
  • Despite improvements in recognizing and treating hypertension, less than half of CKD patients achieved their recommended BP levels according to clinical guidelines.
View Article and Find Full Text PDF

Background: Integrating early mobility (EM) expert consensus recommendations into an algorithm that uses electronic health record (EHR) data provides an opportunity for ICU nurse decision support.

Objective: This study aimed to compare clinical differences in ICU EM algorithm domains among patients with and without documented EM and examine discordance between algorithm classification and documented EM.

Methods: Secondary analysis of EHR data from adults admitted to the ICU from one health system's electronic data warehouse.

View Article and Find Full Text PDF

Background And Purpose: The determination of Aneurysm wall enhancement (AWE) by human readers on visual inspection alone is subjective and prone to error. A three-dimensional (3D) method for quantifying the aneurysm wall's signal intensity (SI) enables objective determination of AWE. Inter-reader agreement and agreement between subjective and objective determination of AWE were assessed in this study.

View Article and Find Full Text PDF
Article Synopsis
  • Blebs, which significantly increase the risk of intracranial aneurysm rupture, were analyzed using radiomic features to understand their unique imaging profile and mechanical interactions.
  • A detailed study involved high-resolution MRI to capture 3D models of bleb-containing aneurysms, allowing for the extraction and comparison of radiomic features between aneurysms with and without blebs.
  • The findings revealed that blebs have distinct radiomic characteristics and that certain features correlate with mechanical metrics, indicating that this analysis could improve rupture risk assessment for aneurysms.
View Article and Find Full Text PDF

Background: Intracranial hemorrhage (ICH) is a serious complication associated with oral anticoagulant use and is associated with significant morbidity and mortality. Although anticoagulation reversal agents are utilized as standard of care, practitioners are limited in their ability to assess degree of anticoagulation reversal for direct oral anticoagulants (DOACs). There is a clinical need identify biomarkers to assess anticoagulation status in patients with DOAC-associated ICH to ensure hemostatic efficacy of anticoagulation reversal agents in the acute setting.

View Article and Find Full Text PDF
Article Synopsis
  • The Hierarchical Taxonomy of Psychopathology (HiTOP) groups mental disorders based on their symptoms and underlying patterns, including a focus on personality functioning (PF) as a significant factor in mental health.
  • This study explored how PF fits into the HiTOP framework and its ability to predict broader issues related to mental health, such as affective well-being (AWB) and psychosocial impairment (PSI), using data from a mental health app with over 27,000 users.
  • Findings suggest that PF plays a crucial role in explaining transdiagnostic variance in mental health conditions and can be useful for clinicians in assessing and treating a variety of disorders by focusing on key aspects of personality functioning.
View Article and Find Full Text PDF

Objectives: The aim of this study was to determine the prevalence of pelvic floor disorders (PFDs) and associated risk factors among parous Ugandan women.

Methods: We performed a cross-sectional study of parous Ugandan women. Demographics and assessment for PFD were obtained.

View Article and Find Full Text PDF

Background: Postpartum hemorrhage (PPH) remains a significant cause of maternal morbidity and mortality around the world, with rates increasing in the United States. The objective of this study was to determine predictors of, and outcomes associated with, PPH at a Midwest academic health center.

Methods: Demographic and clinical data were obtained from the electronic medical record on all consecutive delivering patients between May 1, 2020, and April 30, 2021.

View Article and Find Full Text PDF

Introduction And Hypothesis: The aim was to assess the association between the degree of physical activity (PA) and the presence of pelvic floor disorders (PFDs) in a cohort of parous Ugandan women.

Methods: In this cross-sectional study, PFDs were measured using symptom assessment, standardized questionnaires (Pelvic Floor Distress Inventory and Pelvic Floor Impact Questionnaire), and a standardized physical examination (POP-Q and cough stress test [CST]). Degree of PA was assessed using the International Physical Activity Questionnaire.

View Article and Find Full Text PDF

Introduction And Hypothesis: Pelvic floor disorders (PFDs) impact women worldwide and are assessed using instruments such as the Pelvic Floor Distress Inventory (PFDI-20) and Pelvic Floor Impact Questionnaire (PFIQ-7). There are no known valid PFD instruments in Uganda. This study's purpose was to translate and test the reliability and validity of the PFDI-20 and PFIQ-7 in Luganda.

View Article and Find Full Text PDF

Introduction: Damage-control laparotomy has been widely used in general surgery. However, associated surgical-site infection risks have rarely been investigated. Damage-control laparotomy allows for additional opportunities for decontamination.

View Article and Find Full Text PDF

Objective: To determine the efficacy of a single injection of platelet-rich plasma (PRP) into the anterior vaginal wall at the mid-urethra compared to placebo, as there is emerging evidence that PRP may help treat female stress urinary incontinence (SUI).

Methods: This was a single-blind, randomized, placebo-controlled clinical trial at a single institution. Females with bothersome, demonstrable stress-predominant urinary incontinence were enrolled.

View Article and Find Full Text PDF

It was to understand HPV vaccination patterns, uptake, perceptions, and sexual risk factors in students at a Midwest public university. Students were enrolled during the spring 2024 semester at the University of Iowa. A survey was developed and emailed to 28,095 students asking demographic, general and sexual health, and HPV-related questions.

View Article and Find Full Text PDF