Observer-Based Optimal Backstepping Security Control for Nonlinear Systems Using Reinforcement Learning Strategy.

This article considers an observer-based optimal backstepping security control for nonlinear systems using reinforcement learning (RL) strategy. The main challenge faced is the design of optimal contoller under the deception attacks. Therefore, this article introduces an improved security RL algorithm based on neural network technology under the design framework of critic-actor to resist attacks and optimize the entire system.

Event-Triggered Adaptive Finite-Time Control Using a Fuzzy State Observer for Nonlinear Cyber-Physical Systems Under Deception Attacks.

This article presents a new event-triggered adaptive finite-time control strategy using a fuzzy state observer for a class of nonlinear cyber-physical systems (CPSs) under malicious deception attacks with a more general form. Compared with the traditional assumptions on the deception attacks in the existing results, a more general assumption on deception attacks is given in this article. During the design process, real system states are initially estimated by developing an improved state observer, which effectively addresses the problem of state unavailability.

Supraphysiologic doses of 17β-estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolism.

Background: 17β-Estradiol (E2) is generally considered neuroprotective in humans. However, the current clinical use of estrogen replacement therapy (ERT) is based on the physiological dose of E2 to treat menopausal syndrome and has limited therapeutic efficacy. The efficacy and potential toxicity of superphysiological doses of ERT for menopausal neurodegeneration are unknown.

sp. nov. sp. nov. sp. nov. and sp. nov., isolated from subtropical forest soil.

Four novel bacterial strains, designated RBB1W86, RXD159, RBB189 and RLT163, were isolated from subtropical forest soil of the Nanling National Nature Reserve located in Guangdong Province, PR China. 16S rRNA gene phylogeny indicated their affiliation to the genus , among which strains RBB1W86 and RXD159 were closely related to CGMCC 1.15435 with 16S rRNA gene sequence similarities of 98.

Local buckling behavior of buried pipeline under seismic oblique-reverse fault displacement.

Seismic fault displacement is the main factor leading to local buckling failure of the buried pipeline, especially crossing the oblique-reverse fault. The local buckling behavior of the buried pipeline is complex under the 3-D displacement of the oblique-reverse fault. In this work, the pipe local buckling mechanism was discussed, then a shell and solid element nonlinear contact coupling model of the pipeline crossing oblique-reverse fault was established based on the ABAQUS program.

Metformin promotes maturation of oocytes from aged mice by attenuating mitochondrial oxidative stress SIRT3-dependent SOD2ac.

Human female fecundity decreases irreversibly as chronological age rises, adversely affecting oocyte quality, consequently worsening pregnancy outcomes and increasing the extent of birth defects. The first-line type 2 diabetes treatment metformin has been associated with delayed aging and reduction of oxidative stress; yet it remains unclear if metformin confers any benefits for oocytes from aged mice, particularly in the context of the assisted human reproductive technology (ART) known as maturation (IVM). Here, we found that adding metformin into the M16 culture medium of oocytes from aged mice significantly improved both oocyte maturation and early embryonic development.

Switching Event-Triggered Adaptive Resilient Dynamic Surface Control for Stochastic Nonlinear CPSs With Unknown Deception Attacks.

This work concentrates on the adaptive resilient dynamic surface controller design problem for uncertain nonlinear lower triangular stochastic cyber-physical systems (CPSs) subject to unknown deception attacks based on a switching threshold event-triggered mechanism. The adverse effect of deception attacks on the stochastic CPSs is that the exact system state variables become unavailable. Furthermore, it should be emphasized that the coexistence of unknown nonlinearities, stochastic perturbations, and unknown sensor and actuator attacks makes it a very difficult and challenging event to implement the control design.

Nussbaum-Based Adaptive Fault-Tolerant Control for Nonlinear CPSs With Deception Attacks: A New Coordinate Transformation Technology.

In this article, two novel adaptive fault-tolerant control schemes for a class of nonlinear strict-feedback cyber-physical systems (CPSs) with deception attacks are presented. Deception attacks, such as false data-injection attacks, which destroy sensor networks, make the outputs and states of the CPSs unavailable. It is very difficult and challenging for a designer to achieve the tracking control under the circumstance of cyberattacks.

An Identification System Targeting the SRK Gene for Selecting S-Haplotypes and Self-Compatible Lines in Cabbage.

Cabbage ( L. var. ) self-incompatibility is important for heterosis.

Neural-Network-Based Adaptive Event-Triggered Asymptotically Consensus Tracking Control for Nonlinear Nonstrict-Feedback MASs: An Improved Dynamic Surface Approach.

In this article, the asymptotic tracking control problem for a class of nonlinear multi-agent systems (MASs) is researched by the combination of radial basis function neural networks (RBF NNs) and an improved dynamic surface control (DSC) technology. It's important to emphasize that the MASs studied in this article are nonlinear and nonstrict-feedback systems, where the nonlinear functions are unknown. In order to satisfy the requirement that all items in the controller must be available, the unknown nonlinearities in the system are flexibly approximated by utilizing RBF NNs technique.

PIWI-interacting RNA-23210 protects against acetaminophen-induced liver injury by targeting HNF1A and HNF4A.

Acetaminophen (APAP) overdose is one of the leading causes of acute liver failure in the US and other developed countries, the molecular mechanisms of APAP-induced hepatotoxicity remain speculative. PIWI-interacting RNAs (piRNAs), a novel class of small non-coding RNAs, have been identified as epigenetic regulators of transposon silencing, mRNA deadenylation, and elimination. However, the functional role of piRNAs in APAP-induced liver injury remains unclear.

Organelle Comparative Genome Analysis Reveals Novel Alloplasmic Male Sterility with in L.

Ogura CMS is an alloplasmic male-sterile line introduced from radish by interspecific hybridization and protoplast fusion. The introduction of alien cytoplasm resulted in many undesirable traits, which affected the yield of hybrids. Therefore, it is necessary to identify the composition and reduce the content of alien cytoplasm in Ogura CMS.

FeNiP nanoparticle/N,P dual-doped carbon composite as a trifunctional catalyst towards high-performance zinc-air batteries and overall water electrolysis.

A composite catalyst with a novel construction of bimetallic phosphide FeNiP nanoparticles embedded in an N,P double-doped carbon matrix was prepared. It was demonstrated to be a trifunctional catalyst that can efficiently catalyze the oxygen reduction reaction (ORR), oxygen evolution reaction (OER) and hydrogen evolution reaction (HER). It was found that the introduction of oleylamine during the preparation can adjust the catalytic sites and finally lead to ideal catalytic performances.

Map-based cloning and promoter variation analysis of the lobed leaf gene BoLMI1a in ornamental kale (Brassica oleracea L. var. acephala).

Background: Leaf shape is an important agronomic trait in ornamental kale (Brassica oleracea L. var. acephala).

The Effect of Oxycodone on Post-operative Pain and Inflammatory Cytokine Release in Elderly Patients Undergoing Laparoscopic Gastrectomy.

To evaluate the effect of oxycodone on post-operative pain and inflammation in elderly patients undergoing laparoscopic gastrectomy. Sixty patients who were of both sexes, American Society of Anesthesiologists Physical Status (ASA-PS) Class I or II, over 65 years of age and undergoing an elective laparoscopic radical gastrectomy were randomly divided into two groups: an oxycodone group (Group O) including 20 males and 10 females and a sufentanil group (Group S) including 21 males and 9 females. The post-operative analgesia regimen was as follows: 40 mg of parecoxib sodium and 0.

A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells.

The alcohol dehydrogenases (ADHs) and aldehyde dehydrogenases (ALDHs) play critical roles in alcoholism development and alcohol toxicology; however, few studies have focused on the miRNA-mediated mechanisms underlying the expressions of alcohol-metabolizing enzymes. In the present study, we showed the expression changes of each alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the liver samples of alcoholic hepatitis (AH) patients, and predicted the miRNAs targeting the dysregulated alcohol-metabolizing genes by a systematic in silico analysis. 13 miRNAs were predicted to regulate the expressions of ADH1A, ADH4, and ALDH2, respectively, with hsa-miR-148a-3p (miR-148a) showing the most significant down-regulation in AH patients.

sp. nov. and sp. nov., isolated from abandoned lead-zinc mine.

Two novel strains, designated 92R-1 and 9PBR-1, were isolated from abandoned lead-zinc ore collected in Meizhou, Guangdong Province, PR China. Phylogenetic analyses based on 16S rRNA gene sequences showed that they fell into the genus of r and formed two distinct lineages. Strain 92R-1 was most closely related to JCM 19491 (98.

sp. nov., isolated from subtropical forest soil.

A novel bacterial strain, designated FGD1, was isolated from subtropical forest soil of the Nanling National Forest Park located in Guangdong Province, P.R. China.

sp. nov., isolated from tungsten mine tailing.

A novel pink-pigmented strain, designated 6HR-1, was isolated from tungsten mine tailings in Jiangxi Province, PR China. Cells were Gram-stain-negative, aerobic, non-spore-forming, rod-shaped and motile with a polar flagellum (monotrichous). It could not utilize methanol, methylamine, formaldehyde or formate as a sole carbon source.

and Lee and Jeon 2017 are two later heterotypic synonyms of Chen . 2013 and emended description of the species.

Phylogenetic analysis of the genus had shown that the type strains of , and shared a very close relationship between each other. The 16S rRNA gene sequences similarity values between each other ranged from 99.65 to 99.

An efficient isothermal PCR method for on-site detection of nucleic acid.

Convective PCR (CPCR) is an isothermal nucleic acid amplification technology; however, natural convection exhibits a chaotic and multiplex flow state, resulting in low amplification efficiency and specificity. We placed a polycarbonate strip (p-strip) inside reaction tubes to induce circumfluence by blocking the inner ring that originally allowed fluid to flow at suboptimal temperatures. Moreover, we constructed a dual-temperature instrument to provide appropriate denaturing and annealing zones for CPCR.

A point of care platform based on microfluidic chip for nucleic acid extraction in less than 1 minute.

In view of the complex procedure of nucleic acid extraction, there exists a huge challenge for the widespread use of point-of-care diagnostics for nucleic acid testing. To achieve point-of-care applications in a more rapid and cost-efficient manner, we designed a snake pipe-shaped microfluidic chip so as to accomplish reagents-prestored, time-saving, operation-simple nucleic acid extraction. All reagents needed for this process, including lysis buffer, wash buffer, elution buffer, and so on, were preloaded in the snake pipe and securely isolated by membrane valves, without the need for using any specialized equipment.

Sphingomonas lenta sp. nov., a slowly growing bacterium isolated from an abandoned lead-zinc mine.

A novel slowly growing member of the genus Sphingomonas, designated 1PNM-20, was isolated from an abandoned lead-zinc mine in Meizhou, Guangdong Province, PR China. A polyphasic taxonomic study was performed to characterize the novel strain. Growth occurred on Reasoner's 2A (R2A) agar and peptone-yeast extract (PYE) agar, but not in liquid R2A or PYE media.