Efficacy of Dapagliflozin in the Treatment of Type 2 Diabetes Mellitus Complicated by Coronary Heart Disease: A Meta-Analysis.

Dapagliflozin is a sodium-glucose cotransporter inhibitor that functions to lower blood sugar by promoting glucose excretion. We conducted a meta-analysis to assess the therapeutic efficacy of dapagliflozin in patients with type 2 diabetes mellitus complicated by coronary heart disease. The objective of this analysis is to provide additional clarity on dapagliflozin's effectiveness in this specific patient population.

Meta-analysis of nifedipine and enalapril combination therapy for hypertensive patients with coronary heart disease: A systematic review and meta-analysis.

Background: Numerous clinical studies have demonstrated that the therapeutic efficacy of combining nifedipine and enalapril in treating hypertension with coronary heart disease surpasses that of nifedipine as a stand-alone treatment. However, the current evidence is not yet sufficient due to limitations in the sample size, and further validation is needed. To analyze and assess the clinical impact of nifedipine combined with enalapril on hypertension complicated with coronary heart disease, and provide evidence for rational drug use in clinic.

Thermodynamic Explanation of Surfactant-Free Microemulsions.

There is sufficient evidence to prove that microemulsions can be formed by two immiscible liquids (generally called oil and water components) in the presence of an amphi-solvent rather than traditional surfactants, but how to explain such surfactant-free microemulsions (SFMEs) with thermodynamics is still a challenge. In this work, based on the Flory-Huggins theory, a general thermodynamic principle for SFMEs was established, by assuming SFMEs to be a pseudobinary system consisting of the water-rich and oil-rich components (i.e.

Identification of drivers of global trade in plastic waste based on GCA and ISM-MICMAC model: Taking China, USA and South Africa as cases.

Plastic waste's dual characteristics of "resource" and "pollution" led to the prevalence of trade. The Global Plastic Waste Trade Network (GPWTN) is heterogeneous, and its structure is susceptible to the influence of key countries within it. However, there is a shortage of research on the key countries and trade drivers influencing GPWTN evolution.

Predictive value of the dynamic systemic immune-inflammation index in the prognosis of patients with intracerebral hemorrhage: a 10-year retrospective analysis.

Background And Purpose: The systemic immune-inflammation index (SII) is a novel immune inflammatory marker which has been proven to have excellent predictive value for many diseases. The aim of this study was to investigate the predictive value of SII at different time points after admission for functional outcome at discharge in patients with intracerebral hemorrhage (ICH).

Methods: The clinical data of patients with ICH who were treated at a medical center for neurological diseases in China between October 2012 and April 2022 were analyzed in this retrospective study.

Anion Exchange Membrane Water Electrolysis at 10 A ⋅ cm Over 800 Hours.

Anion exchange membrane water electrolyzer (AEMWE) is a potentially cost-effective technology for green hydrogen production. Although the normal current densities of AEMWEs are below 3 A ⋅ cm, operating them at higher current densities represents an efficient, but little-explored approach to decrease the total cost of hydrogen production. We show here that a benchmark AEMWE has an operational lifetime of only seconds at an ultrahigh current density of 10 A ⋅ cm.

Health risk assessment of municipal solid waste incineration emissions based on regression analysis.

This study examined the potential health risks posed by the operation of 96 waste-to-energy (WtE) plants in 30 cities in the Bohai Rim of China. Utilizing a sophisticated simulation approach, the Weather Research and Forecasting (WRF) model coupled with the California Puff (CALPUFF) model, we obtained the spatial distribution of pollutants emitted by WtE plants in the atmosphere. Hazard indices (HI) and cancer risks (CR) were calculated for each plant using the United States Environmental Protection Agency's recommended methodologies.

Design, synthesis, and biological evaluation of Pyrido[1,2-a]pyrimidin-4-one derivatives as novel allosteric SHP2 inhibitors.

SHP2 (Src homology-2-containing protein tyrosine phosphatase 2) plays an important role in cell proliferation, survival, migration by affecting RAS-ERK, PI3K-AKT, JAK-STAT signaling pathways and so on. Overexpression or gene mutation of SHP2 is closely linked with a variety of cancers, making it a potential therapeutic target for cancer disease. In this paper, 30 target compounds bearing pyrido[1,2-a]pyrimidin-4-one core were synthesized via two-round design strategy by means of scaffold hopping protocol.

High-temperature corrosion-resistant alloy for waste-to-energy plants: Alloy designing, fabrication, and possible corrosion-resistance mechanism.

This study designed a novel high-temperature corrosion-resistant alloy through thermodynamic equilibrium computations. The strength was determined by the integration of precipitation-strengthening species of nickel boride and tungsten solid solution strengthening, while high-temperature corrosion-resistant property was realized through optimized compositional design. Phase stability was enabled by the presence of a face-centered cubic structure.

circKDM1A suppresses bladder cancer progression by sponging miR-889-3p/CPEB3 and stabilizing p53 mRNA.

Circular RNAs (circRNAs) play crucial biological functions in various tumors, including bladder cancer (BCa). However, the roles and underlying molecular mechanisms of circRNAs in the malignant proliferation of BCa are yet unknown. CircKDM1A was observed to be downregulated in BCa tissues and cells.

Synergistic control potential of flue gas pollutants under Ultra-Low emission standards in waste incineration plants.

As the dominant waste disposal process, incineration is regarded as the main incentive for the "not-in-my-backyard" syndrome, and faces an inescapable pressures of ultra-low emissions (ULE). Establishing precise response relationships between emission factors (EFs) and full-process influencing factors can provide guidance for the synergistic mitigation of flue gas pollutants (FGPs). In this work, the multi-dimensional EFs of FGPs were identified by initially integrating FGPs concentration monitoring data of existing 1,226 processing lines in China, technologies applied and operational experience (OE), local economic and political characteristics.

Mechanistic exploration of polytetrafluoroethylene thermal plasma gasification through multiscale simulation coupled with experimental validation.

The ever-growing quantities of persistent Polytetrafluoroethylene (PTFE) wastes, along with consequential ecological and human health concerns, stimulate the need for alternative PTFE disposal method. The central research challenge lies in elucidating the decomposition mechanism of PTFE during high-temperature waste treatment. Here, we propose the PTFE microscopic thermal decomposition pathways by integrating plasma gasification experiments with multi-scale simulations strategies.

Identification of lncRNA-based regulatory mechanisms of Takifugu rubripes growth traits in fast and slow-growing family lines.

Family selection is an important method in fish aquaculture because growth is the most important economic trait. Fast-and slow-growing families of tiger puffer fish (Takifugu rubripes) have been established through family selection. The development of teleost fish is primarily controlled by the growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis that includes the hypothalamus-pituitary-liver.

Achieving sustainable emissions in China: Techno-economic analysis of post-combustion carbon capture unit retrofitted to WTE plants.

China's aims of achieving CO emissions peak by 2030 and carbon neutrality by 2060 are crucial in guiding international efforts to mitigate climate change. Amine-based solvent technologies for capturing CO on a large scale have been implemented as retrofits in various industrial facilities, with a particular focus on coal-fired power plants. Nonetheless, its implementation within the waste-to-energy (WTE) industry is considerably limited and non-existent in China.

Vemurafenib for BRAF V600-mutant Erdheim-Chester disease presenting with bilateral orbital involvement.

ECD is considered to have rapid progression and poor prognosis. Studies have shown that vemurafenib is effective for ECD patients with orbital involvement, but not for ECD with multiple organs. The refinement of treatment approaches and the increased awareness of ECD have led to a dramatic improvement in prognosis.

Assessing the suitability of municipal sewage sludge and coconut bran as breeding medium for Oryza sativa L. seedlings and developing a standardized substrate.

The utilization of organic solid waste (OSW) for preparing standardized seedling substrates is a main challenge due to its temporal and spatial variability. This study aims to form models based on data from the literature and validate them through experiments to explore a standardized seedling substrate. The typical OSW in Hainan Province, including municipal sewage sludge (MSS), coconut bran (CB), seaweed mud (SM), and municipal sewage sludge biochar (MSSB), was used as raw material.

A Testlet Diagnostic Classification Model with Attribute Hierarchies.

In this article, a testlet hierarchical diagnostic classification model (TH-DCM) was introduced to take both attribute hierarchies and item bundles into account. The expectation-maximization algorithm with an analytic dimension reduction technique was used for parameter estimation. A simulation study was conducted to assess the parameter recovery of the proposed model under varied conditions, and to compare TH-DCM with testlet higher-order CDM (THO-DCM; Hansen, M.

A general nonparametric classification method for multiple strategies in cognitive diagnostic assessment.

Cognitive diagnosis models (CDMs) have been used as psychometric tools in educational assessments to estimate students' strengths and weaknesses in terms of cognitive skills learned and skills that need study. In practice, it is not uncommon that questions can often be solved using more than one strategy, which requires CDMs capable of accommodating multiple strategies. However, existing parametric multi-strategy CDMs need a large sample size to produce a reliable estimation of item parameters and examinees' proficiency class memberships, which obstructs their practical applications.

Mitochondria-targeted fluorescent probe for imaging viscosity in hepatic ischemia-reperfusion injury cell model.

The viscosity of the cell microenvironment is a parameter that affects cell physiological processes. A fluorescent probe X-V was designed to detect the viscosity changes of a hepatic ischemia-reperfusion injury (HIRI) cell model with high selectivity and sensitivity. The fluorescence emission wavelength is 615 nm and the Stokes shift can be up to 125 nm, which can be used not only for intracellular viscosity changes stimulated by different drugs but also for the detection of cell viscosity changes in the HIRI cell model.

Inhalation health risk assessment of incineration and landfill in the Bohai Rim, China.

An inhalation health risks assessment of 96 waste to energy (WtE) plants and 178 landfills in the Bohai Rim, located in northeast China, has been conducted. Based on the latest emission inventories in 2020, WRF/CALPUFF was used to simulate the diffusion of pollutants. Population-weighted hazard index (HI) and carcinogenic risk (CR) of incineration and landfill for each pollutant and each target organ impacted were calculated.

Investigation of enhanced H production from municipal solid waste gasification via artificial neural network with data on tar compounds.

An artificial neural network (ANN) is a biologically inspired computational technique that imitates the behavior and learning process of the human brain. In this study, ANN technique was applied to assess the gasification of municipal solid waste (MSW) with the aim of enhancing the H production. The experiments were conducted using a horizontal tube reactor under different parameters: temperatures, MSW loadings, residence times, and equivalence ratios.

Identifying the fate of nitrogenous species during sewage sludge pyrolysis via in-situ tracing of protein-sludge inherent components interactions.

The effect of interactions between different components in sewage sludge on the thermochemical transformation of nitrogenous species is usually neglected, which is important to explain the generation mechanism of some key nitrogenous by-products. Here, we investigated the distribution, form, and chemical properties of the products from sludge-extracted protein (PR) under different pyrolysis scenarios using several in-situ probe techniques, to elucidate the critical role of typical sludge organics/inorganics on the evolution of nitrogenous intermediates and by-products. The results suggested that Ca/Fe/Si/Al-containing inorganics significantly affected the pyrolytic behavior of PR and the thermal transformation of nitrogenous species, while sludge organics, including humic acids and polysaccharides, had limited effects on the temperature-dependent evolution of nitrogenous species in PR.

Environmental, economic, and energy analysis of municipal solid waste incineration under anoxic environment in Tibet Plateau.

The first Municipal solid waste incineration (MSWI) plant in Lhasa, Tibet, the plateau region of China, started its operation in 2018. Considering the elevation and extreme climate (low pressure and low oxygen content) in Tibet, noticeable differences may be envisaged compared to MSWI elsewhere. The aim of this study is to evaluate the environmental impacts, economic benefits, and energy efficiency of this MSWI project with three representative MSWI case in plain region using Life cycle assessment (LCA), Cost-benefit analysis (CBA), and energy analysis methods.

A Nanocomposite of Bismuth Clusters and Bi O CO Sheets for Highly Efficient Electrocatalytic Reduction of CO to Formate.

The renewable-electricity-driven CO reduction to formic acid would contribute to establishing a carbon-neutral society. The current catalyst suffers from limited activity and stability under high selectivity and the ambiguous nature of active sites. Herein, we report a powerful Bi S -derived catalyst that demonstrates a current density of 2.