Publications by authors named "Wenchao Lin"

Article Synopsis
  • Pulmonary arterial hypertension (PAH) is a serious disease linked to the abnormal activation of pulmonary adventitial fibroblasts, and recent research highlights a connection with selenium deficiency.
  • PAH patients have significantly lower serum selenium levels compared to healthy individuals, and those with lower levels may face worse outcomes.
  • Selenium supplementation has shown potential in improving heart function and lung health in rat models of PAH, working through the protein SELENBP1, suggesting that addressing selenium deficiency could be vital for preventing PAH.
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This study evaluates the effects of dietary Chinese herb ultrafine powder (CHUP) supplementation in late-phase laying hens on the quality and nutritional values of eggs. A total of 576 Xinyang black-feather laying hens (300-day-old) were randomly allocated into eight groups for a 120-day feeding trial. Each group contained eight replicates with nine hens per replicate.

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Article Synopsis
  • - The study investigates pulmonary arterial hypertension (PAH), focusing on the early activation of pulmonary arterial smooth muscle cells (PASMCs) and the mechanisms behind it.
  • - Using data from the Gene Expression Omnibus (GEO) and advanced analysis techniques, researchers identified 46 key genes related to PAH, with MACC1 emerging as a crucial gene linked to the disease's progression.
  • - The research indicates that targeting MACC1 could be a potential treatment strategy for PAH, suggesting the need for further clinical studies to evaluate its effectiveness.
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Background: Most patients diagnosed with head and neck tumor will present with locally advanced disease, requiring multimodality therapy. Bone marrow-derived mesenchymal stromal cells (BMSCs) respond to a variety of tumor cell-derived signals, such as inflammatory cytokines and growth factors. As a result, the inflammatory tumor microenvironment may lead to the recruitment of BMSCs.

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  • Sesame oilseed is an ancient crop with high oil content, but its genetic traits are not well understood.
  • The study presents complete genomes of cultivated sesame and six wild species, showing their evolutionary history and key genetic variations that affect growth and disease susceptibility.
  • Insights from this research aim to enhance molecular breeding methods for sesame and other oilseed crops, focusing on traits like oil content and disease resistance.
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic resulted in significant societal costs. Hence, an in-depth understanding of SARS-CoV-2 virus mutation and its evolution will help determine the direction of the COVID-19 pandemic. In this study, we identified 296,728 de novo mutations in more than 2,800,000 high-quality SARS-CoV-2 genomes.

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Article Synopsis
  • The study investigates the impact of Chinese herb ultrafine powder (CHUP) on the health and gut function of laying hens, focusing on factors like jejunal morphology and gut microbiota.
  • A total of 576 hens were fed different diets, including varying percentages of CHUP, over 120 days to assess the effects.
  • Results indicated that specific CHUP combinations enhanced gut morphology and beneficial bacteria levels, suggesting dietary CHUP could positively influence hen health and productivity.
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Pulmonary arterial hypertension (PAH) is a progressive cardiopulmonary disease with unclear underlying molecular mechanisms and limited therapeutic options. This study aimed to explore the role of core fucosylation and the only glycosyltransferase FUT8 in PAH. We observed increased core fucosylation in a monocrotaline (MCT)-induced PAH rat model and isolated rat pulmonary artery smooth muscle cells (PASMCs) treated with platelet-derived growth factor-BB (PDGF-BB).

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With high photoluminescence efficiency and a simple solution synthesis method, lead halide perovskites are expected to be a promising material for display and illumination. However, the toxicity and environmental sensitivity of lead hinder its potential applications. Here, we introduced Sb ions into the lead-free perovskites derivative (NH)SnCl via a doping strategy.

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On December 7, 2022, China adjusted public health control measures, there have been widespread of SARS-CoV-2 infections in Chinese mainland. As the number of infected people increased, the mutation probability of SARS-CoV-2 is also raised. Therefore, it is of great importance to monitor SARS-CoV-2 variants and its mutations in China.

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Zero-dimensional (0D) organic metal halides have captured extensive attention for their various structures and distinguished optical characteristics. However, achieving efficient emission through rational crystal structure design remains a great challenge, and how the crystal structure affects the photophysical properties of 0D metal halides is currently unclear. Herein, a rational crystal structure regulation strategy in 0D Sb(III)-based metal halides is proposed to realize near-unity photoluminescence quantum yield (PLQY).

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Metal halide materials have recently sparked intense research because of their excellent photophysical properties and chemical stability. For example, RbCdCl:Sb exhibits broad emission at about 600 nm with a high photoluminescence quantum yield (PLQY) over 91% and double emission bands with bright white color. Herein, we obtained a novel Rb and Cd layered perovskite RbCdCl doped with Sb, which gives luminescence at 525 nm with a large Stokes shift of 200 nm, originating from a self-trapped exciton (STE).

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Over the past two years, scientists throughout the world have completed more than 6 million SARS-CoV-2 genome sequences. Today, the number of SARS-CoV-2 genomes exceeds the total number of all other viral genomes. These genomes are a record of the evolution of SARS-CoV-2 in the human host, and provide information on the emergence of mutations.

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Idiopathic pulmonary arterial hypertension (IPAH) is a life-threatening cardiopulmonary disease lacking specific diagnostic markers and targeted therapy, and its mechanism of development remains to be elucidated. The present study aimed to explore novel diagnostic biomarkers and therapeutic targets in IPAH by integrated bioinformatics analysis. Four eligible datasets (GSE117261, GSE15197, GSE53408, GSE48149) was firstly downloaded from GEO database and subsequently integrated by Robust rank aggregation (RRA) method to screen robust differentially expressed genes (DEGs).

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Article Synopsis
  • * The study focused on Sb-doped RbCdCl crystalline powder, which was created using a simple hydrothermal method, revealing it emits efficient yellow light at around 596 nm with a high quantum yield of 91.7%.
  • * The emission properties are influenced by temperature and involve transitions between self-trapped exciton states, resulting in a shift to white light at lower temperatures, suggesting potential applications in temperature sensing.
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved rapidly into new variants throughout the pandemic. The Omicron variant has more than 50 mutations when compared with the original wild-type strain and has been identified globally in numerous countries. In this report, we analyzed the mutational profiles of several variants, including the per-site mutation rate, to determine evolutionary relationships.

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Outbreak of global pandemic Coronavirus disease 2019 (COVID-19) has so far caused countless morbidity and mortality. However, a detailed report on the impact of COVID-19 on hypertension (HTN) and ensuing cardiac injury is unknown. Herein, we have evaluated the association between HTN and cardiac injury in 388 COVID-19 (47.

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Background: Congestive heart failure (CHF) is a complex clinical syndrome, with high morbidity and mortality. Serum anion gap (SAG) is associated with the severity of various cardiovascular diseases. However, the role of SAG indicators in CHF is unclear.

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Pulmonary arterial hypertension (PAH) is a lethal disease generally characterized by pulmonary artery remodeling. Mitochondrial metabolic disorders have been implicated as a critical regulator of excessively proliferative- and apoptosis-resistant phenotypes in pulmonary artery smooth muscle cells (PASMCs). Dichloroacetate (DCA) is an emerging drug that targets aerobic glycolysis in tumor cells.

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Objective: Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (PIN1) involves alteration of the structure, function, intracellular localization and/or stability of the phosphorylated protein on serine or threonine residues which relates to inflammation and tumorigenesis. Association between PIN1 promoter polymorphisms and cancer risk were reported in several cancers. We intend to study the relationship between the polymorphism of PIN1 promoter and cervical cancer initiation and development.

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Crustacea, the subphylum of Arthropoda which dominates the aquatic environment, is of major importance in ecology and fisheries. Here we report the genome sequence of the Pacific white shrimp Litopenaeus vannamei, covering ~1.66 Gb (scaffold N50 605.

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Apart from sharing common ancestry with chordates, sea cucumbers exhibit a unique morphology and exceptional regenerative capacity. Here we present the complete genome sequence of an economically important sea cucumber, A. japonicus, generated using Illumina and PacBio platforms, to achieve an assembly of approximately 805 Mb (contig N50 of 190 Kb and scaffold N50 of 486 Kb), with 30,350 protein-coding genes and high continuity.

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Background: The gene for New Delhi metallo-β-lactamase 1 (NDM-1) has been reported to be transmitted via plasmids which are easily transferable and capable of wide distribution. We report the isolation of two NDM-1 producing strains and possible in vivo transfer of blaNDM-1 in a patient.

Methods: Clinical samples were collected for bacterial culture and antibiotic susceptibility testing from a patient during a 34-day hospitalization.

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Background: The isochore, a large DNA sequence with relatively small GC variance, is one of the most important structures in eukaryotic genomes. Although the isochore has been widely studied in humans and other species, little is known about its distribution in pigs.

Principal Findings: In this paper, we construct a map of long homogeneous genome regions (LHGRs), i.

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