Publications by authors named "Wenbo Yang"

Lack of acidity is the main reason for the spoilage of cherry wine, and for insufficient aroma and mouthfeel. In this study, the initial acidity of cherry purees was adjusted to 3.50, 4.

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Considerable interest has emerged in developing biodegradable food packaging materials derived from polysaccharides. Phenolic compounds serve as natural bioactive substances with a range of functional properties. Various phenolic compounds have been incorporated into polysaccharide-based films and coatings for food packaging, thereby enhancing product shelf life by mitigating quality degradation due to oxidation and microbial growth.

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Blueberry is one of the most perishable fruits, and the postharvest supply chain environment temperature has great effects on fruit quality. In order to determine the critical steps referring to non-optimal conditions and the key quality indexes in response to temperature along the cold chain, 15 time-temperature scenarios were conducted simultaneously for the storage of blueberry fruits and 17 quality attributes were determined. The results indicated that different cold chain steps under abusing temperatures significantly affected blueberry qualities.

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Background: Neurovascular coupling (NVC) reflects the close connection between neural activity and cerebral blood flow (CBF) responses, providing new insights to explore the neuropathological mechanisms of various diseases. Non-dialysis patients with chronic kidney disease (CKD) exhibit cognitive decline, but the underlying pathological mechanisms are unclear.

Methods: The prospective study involved 53 patients with stage 1-3a CKD (CKD1-3a), 78 patients with stage 3b-5 CKD (CKD3b-5), and 52 healthy controls (HC).

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The combined pollution of antibiotics and heavy metals in aqueous environments increases the risk of aquatic ecosystem disruption and the complication of pollutant management. Here, a fungus Cladosporium cladosporioides 11 (CC11) isolated from aquaculture pond sediments possessed effective capacities to biotransform the combined pollution of enrofloxacin (ENR) and copper ion (Cu). ENR and Cu were considerably abated by CC11, and the presence of Cu (30 mg/L) promoted the biotransformation efficiency of ENR.

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  • NMOSD is a rare autoimmune disease affecting the CNS, and this study is the first Phase I clinical trial in Chinese patients testing the safety and efficacy of a new drug called BAT4406F, an anti-CD20 monoclonal antibody.
  • The study involved 15 patients who received different doses of BAT4406F, with results showing no dose-limiting toxicities and mostly mild side effects, indicating a favorable safety profile.
  • The drug demonstrated effective B-cell depletion, important for treating NMOSD, with a nonlinear pharmacokinetic profile and longer elimination half-life, suggesting promising therapeutic potential.
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Wide-Field Small Aperture Telescopes (WFSAT) are widely used for surveilling space objects. Due to their wide-field of view (FOV) characteristics, these telescopes can cover a large areas of the sky at once, improving observation efficiency. However, a wide-field optical telescope is highly sensitive to external stray light (such as moonlight and thin clouds), which can significantly reduce the quality of observation data.

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Objectives: To investigate glymphatic function in nondialysis-dependent ESRD (ND-ESRD) patients with diabetic kidney disease (DKD) or non-DKD using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) method and choroid plexus (CP) volume to explore the associations among DTI-ALPS index, CP volume, clinical characteristics, and cognitive function.

Methods: 25 DKD patients, 25 non-DKD patients, and 25 healthy control (HC) were included in this study. All participants underwent cerebral MRI and cognitive assessments.

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The objective of this study was to ascertain the relationship between the weight-adjusted waist index (WWI) and the risk of stroke in an elderly hypertensive population, a relationship that has not been previously elucidated. The Cox regression model was employed to assess the correlation between baseline WWI measurements and the incidence of stroke. To further elucidate the shape of the association between baseline WWI and stroke, restricted cubic splines were employed.

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Background: End-stage renal disease (ESRD) patients on maintenance haemodialysis (HD) often have damage to brain white matter (WM) and cognitive impairment. However, whether this damage is caused by maintenance HD or renal dysfunction is unclear. Herein we investigate the natural progression of WM damage in patients with ESRD and the effects of HD on WM using tract-based spatial statistics (TBSS) and fixel-based analysis (FBA).

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The study was the first to evaluate the synergistic interaction of luteolin + quercetin, luteolin + 3-O-methylquercetin, and quercetin + 3-O-methylquercetin mixtures on α-glucosidase and the binding mechanisms were explored using both experimental and theoretical approaches. The results showed that three flavonoid mixtures exhibited a mixed type of inhibition and demonstrated the most potent synergistic effects on α-glucosidase inhibition at 6:4 ratio, with interaction index (γ) of 0.85, 0.

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Objective: To explore the link between plasma aldosterone concentration (PAC) and the prevalence of metabolic dysfunction-related fatty liver disease (MAFLD) in hypertensive patients.

Methods: We analyzed data from 41,131 hospitalized patients from January 1, 2014, to December 31, 2023. Multivariate logistic regression models tested associations, with threshold, subgroup, and sensitivity analyses conducted to validate findings.

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The plug-flow fixed bed reactors with zeolite/tourmaline-modified polyurethane carriers (PFBR) and polyurethane carriers (PFBR) were operated to assess the fluctuating influent C/N impact on the system performance and the carrier effect on the enhancing the system operation. Result suggested that fluctuations in influent C/N and variations in operational temperature reduced the removal performance and system stability within PFBR. The negative impact of C/N fluctuation could be effectively mitigated by effluent reflux.

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  • Anterior cruciate ligament (ACL) injuries are common in sports, with most cases involving proximal tears, which can affect knee function.
  • A new method called continuous bundle suture technique has been developed to improve ACL repair, allowing for easier and more reliable surgery using suture anchors.
  • This new technique optimizes the use of suture hooks and Scorpion suture passers to effectively repair both anteromedial and posterolateral bundles, potentially addressing issues with existing repair methods.
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With global warming, drought stress is becoming increasingly severe, causing serious impacts on crop yield and quality. In order to survive under adverse conditions such as drought stress, plants have evolved a certain mechanism to cope. The tolerance to drought stress is mainly improved through the synergistic effect of regulatory pathways, such as transcription factors, phytohormone, stomatal movement, osmotic substances, sRNA, and antioxidant systems.

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  • Lower back pain (LBP) is commonly linked to intervertebral disc degeneration, causing significant socioeconomic issues due to inflammation and nerve growth factor (NGF) effects.
  • A new biomimetic nanoparticle, TMNP@SR, is designed to target inflamed discs by delivering rapamycin, which promotes a switch in macrophage types to reduce inflammation.
  • TMNP@SR shows potential in improving LBP in rat models by decreasing nerve-related pain signals and inflammation, suggesting it could be a promising treatment for LBP caused by disc degeneration.
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Background: Prior research has highlighted the association between uric acid (UA) and the activation of the renin-angiotensin-aldosterone system (RAAS). However, the specific relationship between aldosterone, the RAAS's end product, and UA-related diseases remains poorly understood. This study aims to clarify the impact of aldosterone on the development and progression of hyperuricemia and gout in hypertensive patients.

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  • - The study explores the use of sunflower biomass (stems and receptacles) mixed with polyethylene glycol to create shape-stabilized phase change materials, aiming to boost energy efficiency due to their high thermal conductivity and storage capability.
  • - Sunflower stem carbon (SS-PEG) and receptacle carbon (SR-PEG) were synthesized using a vacuum impregnation method, and their structural and thermal properties were analyzed with various techniques like SEM and DSC.
  • - Results indicated that SS-PEG and SR-PEG have significant melting enthalpies of 153.4 J/g and 171.5 J/g, respectively, achieving high loading rates of 81.9% and 91.5%, while also exhibiting good thermal stability with
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Objective: To explore the clinical safety and effectiveness of self-draining ureteral stent with thread in kidney transplant recipients in renal transplantation.

Methods: This study is a prospective cohort clinical study in the Department of Urology of Peking University People's Hospital from November 2022 to January 2024. The ureteral stent with thread group, in which a 2-0 Mersilene suture of 20-30 cm was used at the bladder end of the ureteral stent during the operation.

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Background: A newly introduced obesity-related index, the weight-adjusted-waist index (WWI), emerges as a promising predictor of cardiovascular disease (CVD). Given the known synergistic effects of hypertension and obstructive sleep apnea (OSA) on cardiovascular risk, we aimed to explore the relationship between the WWI and CVD risk specifically within this high-risk cohort.

Methods: A total of 2265 participants with hypertension and OSA were included in the study.

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  • Non-alcoholic fatty liver disease (NAFLD) is linked to higher risks of biochemical recurrence in metastatic prostate cancer patients, particularly those with a Gleason score of 4+3 or greater.
  • A study analyzed 602 metastatic prostate cancer patients undergoing androgen deprivation therapy and found that those with NAFLD had a significantly higher recurrence rate and shorter progression-free survival compared to those without NAFLD.
  • The study concludes that NAFLD may serve as an independent risk factor for recurrence, suggesting that future research should explore whether treating NAFLD could improve patient outcomes.
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Objective: While the role of aldosterone in bone metabolism is well established, the specific effects of the widely used aldosterone antagonist, spironolactone, on bone health are not fully understood. This study aimed to investigate the effects of spironolactone on osteoporosis and future fracture risk in middle-aged and elderly hypertensive patients, revealing its potential benefits for bone health.

Methods: Propensity score matching was employed in this study to create matched groups of spironolactone users and non-users at a 1:4 ratio.

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  • - Tears in the lateral meniscus, especially in the body and posterior horn, are frequent sports injuries that may need arthroscopic surgery; however, the surgery is complicated due to the cramped space in the knee joint.
  • - The new Chinese Union Suture Procedure introduces a posteromedial-transseptal portal, improving the angle for suture hooks, and utilizes a continuous sewing machine-like technique for quicker and more efficient repair of meniscus tears.
  • - This improved method allows for vertical mattress suturing and easier knot tying on the tibial surface, offering a flexible, speedy, and cost-effective approach for addressing meniscus injuries compared to traditional methods.
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