Publications by authors named "Wenbo Qu"

Article Synopsis
  • The study investigates coronary artery calcification (CAC) as a significant indicator of atherosclerosis and its link to clinical outcomes, highlighting the need for better imaging analysis methods.* -
  • Researchers developed a deep learning technique to automatically identify and measure CAC using a large dataset of over 1 million OCT images from 1,048 patients, achieving nearly human-level accuracy in their assessments.* -
  • Analysis of 1,259 patients with ST-segment elevated myocardial infarctions showed that those with more severe calcification in the affected arteries faced a higher risk of major cardiovascular and cerebrovascular events, while calcification in other arteries was not significantly linked to these risks.*
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The early strength of geopolymers (GPs) and their composites is higher, and the hardening speed is faster than that of ordinary cementitious materials. Due to their wide source of raw materials, low energy consumption in the production process, and lower emissions of pollutants, they are considered to have the most potential to replace ordinary Portland cement. However, similar to other inorganic materials, the GPs themselves have weak flexural and tensile strength and are sensitive to micro-cracks.

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Article Synopsis
  • Current atherosclerosis treatments struggle to reverse advanced plaque buildup, with high amino acid levels from a Western diet causing mTORC1-autophagy defects in macrophages, worsening the condition.* -
  • Research identified that the upregulation of Gpr137b-ps in atherosclerotic plaques impacts autophagy, with experiments on mice showing that reducing Gpr137b-ps enhances macrophage autophagy and reduces plaque lesions.* -
  • Gpr137b-ps seems to inhibit the binding of HSC70 to G3BP, which in turn affects mTORC1 signaling, suggesting targeting this pathway could offer a new avenue for treating advanced atherosclerosis.*
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Acute coronary syndrome (ACS) is a group of clinical syndromes characterized by rupture or erosion of atherosclerotic unstable plaques. Effective intervention for vulnerable plaques (VP) is of great significance to reduce adverse cardiovascular events. Fbn1 mice were crossbred with LDLR mice to obtain a novel model for atherosclerotic VP.

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To identify differential mRNA and ncRNA expression profiles and competing endogenous RNA-associated regulatory networks during the progression of atherosclerosis (AS). We systematically analyzed whole-transcriptome sequencing of samples from different stages of AS to evaluate their long noncoding RNA (lncRNA), circular RNA (circRNA), miRNA and mRNA profiles. We constructed three AS-related competing endogenous RNA regulatory networks of differentially expressed circRNAs, lncRNAs, miRNAs and mRNAs.

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Percutaneous coronary intervention, which is safe, effective, and timely, has become an important treatment for coronary artery diseases and has been widely used in clinical practice. However, there are still some problems that urgently need to be solved. Permanent vessel caging through metallic implants not only prevents the process of positive vessel remodeling and the restoration of vascular physiology but also makes the future revascularization of target vessels more difficult.

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In-stent restenosis (ISR) still exists after drug-eluting stent (DES) implantation, even up to one year. The incidence and risk factors for neoatherosclerosis in patients with early ISR have not yet been elucidated. Here, we used optical coherence tomography (OCT) to evaluate the incidence and predictors of neoatherosclerosis in patients with early ISRs.

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Objective: Despite the current antiatherosclerotic and antithrombotic therapies, the incidence of advanced atherosclerosis-associated clinical events remains high. Whether long noncoding RNAs (lncRNAs) affect the progression of atherosclerosis and whether they are potential targets for the treatment of advanced atherosclerosis are poorly understood. Approach and Results: The progression of atherosclerotic lesions was accompanied by dynamic alterations in lncRNA expression, as revealed by RNA sequencing and quantitative polymerase chain reaction.

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To explore new practical means of alleviating the negative effect of heat stress on rice plants during the heading-flowering stage, a field experiment was conducted in Ji'an, Yugan, and Nanchang counties of Jiangxi Province from 2017 to 2018 with three indica hybrid rice varieties. Under ambient high temperature condition during the heading-flowering period, we sprayed five concentrations of salicylic acid (SA) (SA-SA: 100, 500, 1000, 1500, 2000 μmol·L) and five concentrations of KHPO (K-K: 7.35, 14.

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Background: Coronary bifurcation remains one of the most challenging lesion subsets in interventinal cardiology. Provisional stenting (PS) is the dominate technique for bifurcation lesions, but the key problem is the deterioration of side branch. Balloon-stent kissing technique (BSKT) as a new systematic approach which is based on modified jailed balloon technique is applied to improve the procedure success.

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Feed‑forward loops (FFLs) are three‑gene modules that exert significant effects on a series of biological processes and carcinogenesis development. MicroRNA‑associated FFLs (miR‑FFLs) represent a new era in disease research. However, analysis of the miR‑FFL network motifs has yet to be systematically performed, and their potential role in cardiac hypertrophy and acute myocardial infarction (AMI) requires investigation.

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The aim of the study was to use the ovine model to evaluate the hemocompatibility and end-organ effects of a newly developed magnetic suspension centrifugal left ventricular assist device (LVAD) by CH Biomedical Inc., Jiangsu, China. The LVADs were implanted in 6 healthy sheep, where inflow was inserted into the left ventricular apex and outflow was anastomosed to the descending aorta.

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