Association between ESR1 and COL1A1 gene polymorphisms and skeletal fluorosis in Tibetan, Kazakh, Mongolian and Russian populations, China.

Background: Skeletal fluorosis is a chronic metabolic bone disease caused by excessive accumulation of fluoride in the bones. Previous studies have found that when the intake of tea fluoride is similar, the prevalence of skeletal fluorosis varies greatly among different ethnic groups, which may be related to different genetic backgrounds. Single nucleotide polymorphisms (SNPs) of estrogen receptor 1 (ESR1) and collagen type 1 α1 (COL1A1) were strongly associated with bone metabolism as well as bone growth and development, but their association with the risk of skeletal fluorosis has not been reported.

Synthesis of metal-organic framework-luminescent guest (MOF@LG) composites and their applications in environmental health sensing: A mini review.

Metal-organic framework (MOF) materials are three-dimensional structures formed by the combination of metal ions and organic ligands. So far, various typical metal organic framework materials have emerged, such as ZIF-8, MOF-5, UIO-66, etc. These traditional MOF materials have the advantages of simple synthesis, high porosity, and high stability, and have great research potential in the field of fluorescence sensing.

Study on the mechanism of macrophages activated by phosphoesterified rehmanniae polysaccharide on human gastric cancer cells.

Gastric cancer(GC)is one of the most common gastrointestinal malignant tumors in the world, requiring the development of novel therapeutic agents with reduced toxicity. Rehmannia polysaccharide (RPS) possesses immunomodulatory and anti-tumor properties, yet its efficacy is suboptimal. To enhance its biological activity, we subjected RPS to molecular modifications, resulting in phosphorylated Rehmannia polysaccharides (P-RPS).

Pathophysiological relevance and therapeutic outlook of GPR43 in atherosclerosis.

Atherosclerosis (AS) is an inflammatory arterial disorder that occurs due to the deposition of the excessive lipoprotein under the artery intima, mainly including low-density lipoprotein and other apolipoprotein B-containing lipoproteins. G protein-coupled receptors (GPCRs) play a crucial role in transmitting signals in physiological and pathophysiological conditions. GPCRs recognize inflammatory mediators, thereby serving as important players during chronic inflammatory processes.

Metal-organic frame material encapsulated Rhodamine 6G: A highly sensitive fluorescence sensing platform for the detection of picric acid contaminants in water.

As a water pollutant with excellent solubility, 2,4,6-trinitrophenol (also known as picric acid, PA) poses a potential threat to the natural environment and human health, so it is crucial important to detect PA in water. In this study, a novel composite material (MIL-53(Al)@R6G) was successfully synthesized by encapsulating Rhodamine 6G into a metal-organic frame material, which was used for fluorescence detection of picric acid (PA) in water. The composite exhibits bright yellow fluorescence emission with a fluorescence quantum yield of 58.

Impact of -Methyl-2-pyrrolidone Erosion on Surface Functional Groups and Pore Evolution in Coals of Different Ranks.

In low-permeability coal reservoirs, utilizing the organic solvent -methyl-2-pyrrolidone (NMP) has emerged as an effective approach to improving the coal pore structure and enhancing coalbed methane productivity. However, the exact mechanisms of how solvent erosion alters functional groups and develops pores remain incompletely understood. This study utilized Fourier transform infrared spectroscopy and low-field nuclear magnetic resonance to assess the impact of NMP on the functional groups and pore structures of lignite, bituminous coal, and anthracite.

Zirconium-based metal-organic framework encapsulated dye molecules: An excellent sensing platform for sensitive detection of Cu in aqueous environments.

Residual heavy metal ions in water pose a major hazard to ecology as well as human health, and Cu, as the most common heavy metal ion in water bodies, can cause a variety of diseases in human beings with prolonged exposure, therefore, a rational sensing platform is needed for the specific detection of Cu. In this work, based on the solvothermal method, we successfully prepared the composite UIO-66@FS by encapsulating the dye fluorescein sodium molecule (FS) with a metal-organic framework material (UIO-66). The composite material has bright fluorescence emission properties with a fluorescence quantum yield of 62.

Progesterone receptor membrane component 2 regulates the neuronal activity and participates in epileptic seizures in experimental mice.

It was found the expression of progesterone receptor membrane component 2 (PGRMC2) in the histone of epileptic mice was lower than that of normal mice. In this study, we found by the immunofluorescence technique, PGRMC2 was expressed in both astrocytes and neurons of the mouse hippocampus. In addition, the seizure latency and seizure grade of mice in each group were observed after stereotactic injection of the PGRMC2 knockdown virus, PGRMC2 overexpression lentivirus, and related null virus into the hippocampus of mice.

Molecular Simulation of the Effects of Cyclic Organic Compounds on the Stability of Lccbm Hydrates.

CH can be separated from low-concentration coal bed methane (LCCBM) by using the hydrate-based gas separation (HBGS) method. To study the contribution of different cyclic organic compounds to the separation of CH in LCCBM, an LCCBM hydrate model was constructed. Based on the Monte Carlo and molecular dynamics theory, we simulated the effect of three cyclic organic compounds-cyclopentane (CP), cyclopentanone (CP-one), and cyclopentanol (CP-ol)-on the stability of the LCCBM hydrate at P = 2 MPa, various temperatures, and discussed the structural stability of the hydrate in depth in terms of final snapshots, radial distribution function, mean square displacement, diffusion coefficient, and potential energy change.

Multi-Focus Image Fusion Based on Convolution Neural Network for Parkinson's Disease Image Classification.

Parkinson's disease (PD) is a common neurodegenerative disease that has a significant impact on people's lives. Early diagnosis is imperative since proper treatment stops the disease's progression. With the rapid development of CAD techniques, there have been numerous applications of computer-aided diagnostic (CAD) techniques in the diagnosis of PD.

The Progress in Diagnosis and Treatment of Exosomes and MicroRNAs on Epileptic Comorbidity Depression.

The occurrence of epilepsy can increase the incidence of depression, and the risk of epilepsy in the patients with depression is also high, both of which have an adverse effect on the life and the psychology of the patient, which is not conducive to the prognosis of the patients with epilepsy. With lucubrating the function of exosomes and microRNAs, some scholars found that the exosomes and its microRNAs have development prospect in the diagnosis and treatment of the disease. MicroRNAs are involved in the regulation of seizures and depression, as biomarkers, that can significantly improve the management of epileptic patients and play a preventive role in the occurrence of epilepsy and epilepsy depressive disorder.

Insecticidal Activity of Four Lignans Isolated from .

A new lignan () and three known lignans (, , and ) were isolated from the methanol extract of the roots of using bioassay-guided method, and their structures were identified as phrymarolin I (), II (), haedoxan A (), and methyl 4-((6a-acetoxy-4-(6-methoxybenzo[d][1,3]dioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl)oxy)-1-hydroxy-2,2-dimethoxy-5-oxocyclopent-3-ene-1-carboxylate () byNMR and ESI-MS spectral data. Bioassay results revealed that haedoxan A exhibited remarkably high insecticidal activity against with a stomach toxicity LC value of 17.06 mg/L and a topical toxicity LC value of 1123.

Synthesis and in vitro antitumor evaluation of dihydroartemisinin-cinnamic acid ester derivatives.

To explore novel high efficiency and low toxicity antitumor agents, a series of dihydroartemisinin-cinnamic acid ester derivatives modified on C-12 and/or C-9 position (s) were synthesized and the in vitro antitumor activities against PC-3, SGC-7901, A549 and MDA-MB-435s cancer cell lines were assessed. The hybrids (3-36) were prepared by esterification of 9α-hydroxyl-dihydroartemisinin (9α-OH DHA), the biotransformation product of dihydroartemisinin (DHA), and cinnamic acid derivatives. Compound 17 (IC50 = 0.