Embedded 3D Printing for Microchannel Fabrication in Epoxy-Based Microfluidic Devices.

Microfluidic devices offer promising solutions for automating various biological and chemical procedures. Epoxy resin, known for its excellent mechanical properties, chemical resistance, and thermal stability, is widely used in high-performance microfluidic devices. However, the poor printability of epoxy has limited its application in 3D printing technologies for fabricating epoxy-based microfluidic devices.

A 5:2 Intermittent Fasting Meal Replacement Diet and Glycemic Control for Adults With Diabetes: The EARLY Randomized Clinical Trial.

Importance: An intermittent fasting plan consisting of 2 nonconsecutive fasting days and 5 days of habitual intake per week and meal replacement diet (5:2 MR) could provide additional benefits to patients with type 2 diabetes.

Objective: To evaluate the effect of the 5:2 MR on glycemic control among patients with early type 2 diabetes compared with metformin and empagliflozin.

Design, Setting, And Participants: The EARLY (Exploration of Treatment of Newly Diagnosed Overweight/Obese Type 2 Diabetes Mellitus) study is a randomized, open-label, active parallel-controlled clinical trial conducted between November 13, 2020, and December 29, 2022, in 9 centers across China.

Caffeic acid-grafted chitosan/sodium alginate/nanoclay-based multifunctional 3D-printed hybrid scaffolds for local drug release therapy after breast cancer surgery.

Breast cancer is one of the most common malignant tumors in women all over the world. Mastectomy is the most effective treatment, but there are serious problems such as high tumor recurrence rate and side effects of chemotherapy. Therefore, there is an urgent need for a therapeutic strategy that can effectively promote postoperative wound healing and inhibit local tumor recurrence.

Sacrificial scaffold-assisted direct ink writing of engineered aortic valve prostheses.

Heart valve disease has become a serious global health problem, which calls for numerous implantable prosthetic valves to fulfill the broader needs of patients. Although current three-dimensional (3D) bioprinting approaches can be used to manufacture customized valve prostheses, they still have some complications, such as limited biocompatibility, constrained structural complexity, and difficulty to make heterogeneous constructs, to name a few. To overcome these challenges, a sacrificial scaffold-assisted direct ink writing approach has been explored and proposed in this work, in which a sacrificial scaffold is printed to temporarily support sinus wall and overhanging leaflets of an aortic valve prosthesis that can be removed easily and mildly without causing any potential damages to the valve prosthesis.

Experimental investigation on high-pressure methane jet characteristic single-hole injector.

High-pressure gas direct injection (DI) technology benefits engines with high efficiency and clean emissions, and the gas jet process causes crucial effects especially inside an mm-size space. This study presents an investigation on the high-pressure methane jet characteristics from a single-hole injector by analysing jet performance parameters including jet impact force, gas jet impulse, and jet mass flow rate. The results show that the methane jet exhibited a two-zone behaviour along the jet direction in the spatial dimension induced by high-speed jet flow from the nozzle: zone 1 near the nozzle-the jet impact force and jet impulse increased consistently except for a fluctuation due to shock wave effects induced by the sonic jet and no entrainment occurs, and zone II farther away from the nozzle-the jet impact force and jet impulse became stable when the shock wave effects became weak and the jet impulse was conserved with a linear conservation boundary.

Experimental Study of Dual-Fuel Diesel/Natural Gas High-Pressure Injection.

Dual-fuel diesel/natural gas direct-injection engine is promising and highly attractive due to its low-carbon emission and high thermal efficiency, and both high-pressure diesel and natural gas injections are critical for air-fuel mixing. This study presents an optical experimental investigation on the high-pressure dual-fuel diesel/methane injection process based on a constant-volume vessel test rig. The results show that the diesel penetration process of the dual-fuel injection experiences two stages: Stage I, the diesel tip penetration , the diesel spray area , and the diesel spray perimeter of the dual-fuel injection are smaller than those of the single diesel injection.

Astragaloside attenuates lipopolysaccharide-induced cell apoptosis in human gingiva cells via MAPK signaling pathway.

Subjects: The aim of this study was to research the antiapoptotic effect of astragaloside, the principal component of Astragalus membranaceus (Fisch) Bge, in human gingiva cells induced by lipopolysaccharide (LPS).

Methods: According to the treatment, human gingiva cells were divided into five groups, including (1) control group without drug treatment; (2) imitating group, treated with LPS (10 μg·mL ) alone; (3) low group, treated with LPS and 50 μmol·L astragaloside; (4) medium group, treated with LPS and 100 μmol·L astragaloside; and (5) high group, treated with LPS and 150 μmol·L astragaloside. Cell proliferation and apoptosis were investigated using MTT assay and flow cytometry, respectively.

Synthesis of Sulfonylated Lactams by Copper-Mediated Aminosulfonylation of 2-Vinylbenzamides with Sodium Sulfinates.

Treatment of 2-vinylbenzamide derivatives with sulfinate sodium in the presence of Cu(NO)·3HO led to an intra/intermolecular aminosulfonylation reaction to produce sulfonylated lactams in moderate to good yields. The developed method features the easily available and stable sulfone reagents, ease of operation, and a broad functional group tolerance.

Self-propagating Combustion Triggered Synthesis of 3D Lamellar Graphene/BaFe12O19 Composite and Its Electromagnetic Wave Absorption Properties.

The synthesis of 3D lamellar graphene/BaFe12O19 composites was performed by oxidizing graphite and sequentially self-propagating combustion triggered process. The 3D lamellar graphene structures were formed due to the synergistic effect of the tremendous heat induced gasification as well as huge volume expansion. The 3D lamellar graphene/BaFe12O19 composites bearing 30 wt % graphene present the reflection loss peak at -27.

Expanded graphite embedded with aluminum nanoparticles as superior thermal conductivity anodes for high-performance lithium-ion batteries.

The development of high capacity and long-life lithium-ion batteries is a long-term pursuing and under a close scrutiny. Most of the researches have been focused on exploring electrode materials and structures with high store capability of lithium ions and at the same time with a good electrical conductivity. Thermal conductivity of an electrode material will also have significant impacts on boosting battery capacity and prolonging battery lifetime, which is, however, underestimated.

[Clinical application of surgical intervention model for repairing tuberculosis wound with sinus tract].

Objective: To retrospectively explore the effectiveness of surgical intervention model for repairing the tuberculosis wound with sinus tract.

Methods: Forty-three patients with tuberculosis wound with sinus tract who met the inclusion criteria were admitted to the 309th Hospital of PLA from January 2010 to October 2015. These patients were divided into test group (n=38) and control group (n=5) according to the different treatment and patient's consent.

Split Ssp DnaB mini-intein-mediated production of recombinant human glucagon-like peptide-1/7-36.

Glucagon-like peptide-1 (GLP-1) plays an important role in the regulation of postprandial insulin release. Here, we used the split DnaB mini-intein system to produce recombinant human GLP-1/7-36 (rhGLP-1) in Escherichia coli. The C-terminal domain of DnaB mini-intein (IntC) was genetically fused at the N-terminus of rhGLP-1 to produce IntC-GLP-1.

Assessment of serum arginase I as a type 2 diabetes mellitus diagnosis biomarker in patients.

Previous studies have reported that levels of serum arginase I are increased in certain diseases. However, the exact association between arginase I and diabetes mellitus (DM) has yet to be determined. The aim of the present study was to investigate the correlation between arginase I activity and DM to determine whether arginase I activity may be used as a diagnostic biomarker for DM.

Pleuropneumonectomy for diffuse pleural metastasis in primary lung cancer.

Objective: The purpose of this study is to analyze a single institution experience with pleuropneumonectomy for pleural metastasis and malignant pleural effusion in primary lung cancer.

Materials And Methods: From August 1978 to August 2011, 66 consecutive patients with lung cancer underwent pleuropneumonectomy. Patients were followed-up after the operation.

Construction and characterization of a novel chimeric antibody c3C7 specific for the integrin αIIbβ3 complex.

A murine monoclonal antibody (mAb) 3C7 against integrin αIIbβ3 was previously obtained as a potential antithrombotic agent in our laboratory. The epitope of 3C7 is a specific conformation of the αIIbβ3 complex, but not either of the two subunits, which makes it different from abciximab, a supplementary antibody drug used in percutaneous coronary intervention which has a cross-reaction with other integrins sharing the β3 subunit. To reduce the human anti-mouse antibody reactions of 3C7, the variable regions of this antibody were cloned and fused with the constant counterparts of human IgG1.

The novel pro-osteogenic activity of NUCB2(1-83.).

NUCB2¹⁻⁸³ has been recently reported as an anorexigenic and anti-hyperglycemic peptide. Here we report that NUCB2¹⁻⁸³ promotes osteogenesis. It was found after two months of once-a-day intravenous injection of NUCB2¹⁻⁸³, bone mineral density of femora and lumbar vertebrae were increased in ovariectomized rats.