Integrated biosensor array for multiplex biomarkers cancer diagnosis via in-situ self-assembly carbon nanotubes with an ordered inverse-opal structure.

To enhance the precision and reliability of early disease detection, especially in malignancies, an exhaustive investigation of multi-target biomarkers is essential. In this study, an advanced integrated electrochemical biosensor array that demonstrates exceptional performance was constructed. This biosensor was developed through a controllable porous-size mechanism and in-situ modification of carbon nanotubes (CNTs) to quantify multiplex biomarkers-specifically, C-reaction protein (CRP), carbohydrate antigen 125 (CA125), and carcinoembryonic antigen (CEA)-in human serum plasma.

Multiplex signal amplification for ultrasensitive CRP assay via integrated electrochemical biosensor array using MOF-derived carbon material and aptamers.

Accurate and precise detection of disease-associated proteins, such as C-reactive protein (CRP), remains a challenge in biosensor development. Herein, we present a novel approach－an integrated disposable aptasensor array－designed for precise, ultra-sensitive, and parallel detection of CRP in plasma samples. This integrated biosensing array platform enables multiplex parallel testing, ensuring the accuracy and reliability in sample analysis.

Stratifying ASD and characterizing the functional connectivity of subtypes in resting-state fMRI.

Background: Although stratifying autism spectrum disorder (ASD) into different subtypes is a common effort in the research field, few papers have characterized the functional connectivity alterations of ASD subgroups classified by their clinical presentations.

Methods: This is a case-control rs-fMRI study, based on large samples of open database (Autism Brain Imaging Data Exchange, ABIDE). The rs-MRI data from n = 415 ASD patients (males n = 357), and n = 574 typical development (TD) controls (males n = 410) were included.

The impact of digital inclusive finance on corporate ESG performance: based on the perspective of corporate green technology innovation.

Enterprises are important subjects in the transformation of national green development, while financial support is an important thrust to promote the fulfillment of environmental responsibility. In the dual context of building a digital inclusive financial system and green transformation of corporate production, this paper explores the impact of digital inclusive finance on corporate ESG performance and its mechanism of action through theoretical and empirical analyses using data of Chinese A-share listed enterprises from 2011 to 2020. It is found that the development of digital inclusive finance significantly contributes to the improvement of corporate ESG performance, and the impact of digital inclusive finance on corporate ESG performance has a marginal decreasing effect, while corporate green technology innovation has a marginal increasing effect on corporate ESG performance.

Digital inclusive finance, financial mismatch and the innovation capacity of small and medium-sized enterprises: Evidence from Chinese listed companies.

As the main driver of innovation, enterprises can effectively promote the level of social innovation. This paper incorporates digital inclusive finance into the research framework of innovation in Small and Medium-sized enterprises, and investigates the impact of digital inclusive finance on the innovation ability of Small and Medium-sized enterprises through theoretical and empirical analyses. The theoretical analysis finds that digital inclusive finance can compensate for the "long-tail effect" in the financing process and help enterprises obtain financing loans.

Activity-Dependent Differential Regulation of Auts2 Isoforms In Vitro and In Vivo.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder of unknown cause, although one hypothesis suggests a potential imbalance between excitation and inhibition that leads to changes in neuronal activity and a disturbance in the brain network. However, the mechanisms through which neuronal activity contributes to the development of ASD remain largely unexplained. In this study, we described that neuronal activity at the transcriptional and translational levels regulated the expression of Auts2 isoforms.

Untangle the Multi-Facet Functions of Auts2 as an Entry Point to Understand Neurodevelopmental Disorders.

Neurodevelopmental disorders are psychiatric diseases that are usually first diagnosed in infancy, childhood and adolescence. Autism spectrum disorder (ASD) is a neurodevelopmental disorder, characterized by core symptoms including impaired social communication, cognitive rigidity and repetitive behavior, accompanied by a wide range of comorbidities such as intellectual disability (ID) and dysmorphisms. While the cause remains largely unknown, genetic, epigenetic, and environmental factors are believed to contribute toward the onset of the disease.

Superiority of blind over sighted listeners in voice recognition.

The current study examined whether the blind are superior to sighted listeners in voice recognition. Three subject groups, including 17 congenitally blind, 18 late blind, and 18 sighted, showed no significant differences in the immediate voice recognition test. In the delayed test conducted two weeks later, however, both congenitally blind and late blind groups performed better than the sighted with no significant difference between the two blind groups.

Altered connectivity of the visual word form area in the low-vision population: A resting-state fMRI study.

The present study investigated the resting-state functional connectivity (FC) of the visual word form area (VWFA) in low-vision people. Participants were 25 sighted and 37 low-vision individuals. During the experiment, participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans.