Publications by authors named "WenZhe Li"

Background: Echinococcosis is a zoonotic parasitic disease prevalent in pastoral areas, mainly involving the liver and lungs, and rarely affecting the brain and heart. This article describes the diagnosis and treatment of 14 patients with cardiac encapsulated cysts, with the aim of providing insights into the clinical presentation, diagnostic challenges, therapeutic strategies, and outcomes associated with cardiac encapsulated cysts.

Methods: This retrospective case series included 13 patients with cardiac and/or cerebral encapsulated cysts.

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Loading with non-metal cocatalysts to regulate interfacial charge transfer and separation has become a prominent focus in current research. In this study, g-CN/CNT composites loaded with non-metallic cocatalysts were prepared through pyrolysis using urea and CNTs. Various characterization techniques, including transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), ultraviolet-visible diffuse reflectance spectroscopy (UV-vis DRS), photoelectrochemical (PEC) analysis, fluorescence lifetime spectroscopy (TRPL), electron paramagnetic resonance spectroscopy (ESR), and photoluminescence (PL) spectroscopy, were employed to analyze the sample's microstructure, phase composition, elemental chemical states, and photoelectronic properties.

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CsSbBr, as a sort of novel lead-free perovskite single crystal, has the merits of high carrier mobility and a long diffusion length. However, the large-sized and high-crystallized CsSbBr single crystals are not easily obtained. Herein, we apply the vertical Bridgman method to grow centimeter-sized CsSbBr single crystal.

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Drought is one of the most serious environmental stresses affecting crop production. NAC transcription factors play a crucial role in responding to various abiotic stresses in plants. Here, we identified a maize NAC transcription factor, , between drought-tolerant and drought-sensitive inbred lines through RNA-seq analysis and characterized its function in .

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Greengage alcoholic beverage (GAB) is gaining popularity for its distinctive fruity aroma and nutritional benefits. The strain applied for fermentation significantly influences the metabolic production of aroma compounds, making the selection of strains to be critical for enhancing the unique flavor profile of the GAB in commercial production. In this study, the effects of two common commercial strains (SY, EC-1118) and two laboratory-derived strains (ET008-c54, NM-8) on the flavor profile of the GAB were investigated.

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Stress granules (SGs) are membraneless cytoplasmic compartments that form in response to stress stimuli. In these compartments, most translation factors stall, except for activating transcription factor 4 (ATF4), which is preferentially translated to ensure cell survival under stressful conditions. Cancer cells encounter various stress conditions in the tumor microenvironment during tumorigenesis; however, how they exploit the pro-survival effects of ATF4 in SGs remains unclear.

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Background: Obstructed defecation syndrome (ODS) represents the most prevalent form of chronic constipation, affecting a diverse patient population, leading to numerous complications, and imposing a significant burden on healthcare resources. Most ODS patients have insufficient rectal propulsion, but the exact mechanism underlying the pathogenesis of ODS remains unclear.

Aim: To explore the molecular mechanism underlying the pathogenesis of ODS.

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Glutamine is the most abundant amino acid in human blood and muscle, and is integral to a wide variety of functions in cancer cells. However, the inability to monitor the subcellular distribution of glutamine in real-time has obscured understanding of glutamine metabolism under physiological and pathological conditions. Here, we report the development of a genetically encoded fluorescent sensor and demonstrate how this GlnBP-cpYFP fusion "GlutaR sensor" undergoes glutamine-induced conformational changes reflected in detectable fluorescence responses.

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The chemical property of the buried interface plays a crucial role in improving the performance and stability of perovskite solar cells (PSCs). The SnO/perovskite interface prepared from SnO alkaline hydrogel with high proton affinity triggers directional migration and irreversible reactions of protons, exacerbating the disintegration of perovskite crystal. In this study, we proposed proton precompensation strategy to suppress the deprotonation effect of the buried interface and improve the durability of the devices.

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Article Synopsis
  • The study investigates the relationship between diabetes, particularly focusing on the gene WFS1, and endometrial cancer (EC) outcomes.
  • Researchers found WFS1 expression to be significantly lower in EC patients, indicating it may serve as a diagnostic and prognostic marker.
  • Low WFS1 levels are linked to worse prognosis, increased tumor malignancy, and resistance to treatment, highlighting its potential role in assessing cancer risk in diabetic patients.
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Recently, there has been a growing interest in the biocontrol activity of volatile organic compounds (VOCs) produced by microorganisms. This study specifically focuses on the effects of VOCs produced by the co-culture of B418 and T11-W for the control of two phytopathogenic fungi, and f. sp.

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Article Synopsis
  • * A new strategy is introduced that combines a trimethylolpropane triacrylate anchoring layer and an 18-Crown-6 molecular passivator to help control the crystal growth and reduce defects, enabling better alignment of transition dipole moments.
  • * The resulting "coherence-programmed emission layer" enhances LP-PeLED performance, achieving up to 23.7% external quantum efficiency, high brightness of 36,142 cd/m, and a degree
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Study Design: Retrospective cohort study.

Objectives: Investigate the risk factors for delayed extubation after posterior approach orthopedic surgery in patients with congenital scoliosis.

Methods: The clinical data of patients who received surgery for congenital scoliosis at the First Affiliated Hospital of Xinjiang Medical University between January 2021 and July 2023 have been gathered.

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This study aimed to investigate the efficiency of the secondary metabolites (SMs) produced by a co-culture of TW21990 and B418 in the control of CM9. A fermentation filtrate of B418 + TW21990 co-culture (BT21) produced a notable increase in the inhibition rate of CM9 compared to those of TW21990 and B418 monocultures, which reached 91.40% and 80.

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Article Synopsis
  • Metabolic dysfunction-associated steatohepatitis (MASH) complicates the delivery of therapeutic proteins due to excess extracellular matrix (ECM), leading to the development of a new treatment strategy called "Fibrosis overexpression and retention (FORT)."
  • FORT utilizes specially designed retinoid-derivative lipid nanoparticles (LNPs) that enhance mRNA expression in fibrotic areas and include modifications to promote protein anchoring in the ECM.
  • The approach has shown a tenfold increase in protein expression and improved retention of engineered therapeutic proteins in fibrotic lesions, proving effective in various animal models of MASH while reducing toxicity.
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Background: This study investigated the association between vasoactive medication exposure and mortality risk in patients with sepsis using the norepinephrine equivalent (NEE) score and vasoactive-inotropic score (VIS).

Methods: This retrospective cohort study included adult patients with sepsis requiring vasoactive agents. The data were extracted from the Medical Information Mart for Intensive Care IV database.

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Monitoring the effector function of cytotoxic T lymphocytes (CTLs) remains a great challenge. Here, we develop a chemistry-enabled enzymatic labeling approach to evaluate the tumor-specific immune response of CTLs by precisely monitoring the interaction between CTLs and tumor cells. sortase A (SrtA) is linked to the CTL surface through bioconjugate chemistry and then catalyzes the transfer of fluorescent-labeled substrate, 5-Tamra-LPETG, to CTLs.

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The dissipation behavior of granular balls inside quasi-two-dimensional closed containers with different levels of bottom bumpiness under vibration is examined in this article using the discrete element method. The quasi-two-dimensional closed granular system used in this paper has dimensions of , and the diameters of the 279 filled granular balls are 4 mm. First, the dynamic behavior and damping effects of granular balls within a flat-bottomed closed container are explored across the range of relevant excitation parameters, identifying four high damping granular phases.

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Terpenoids are structurally diverse natural products that have been widely used in the pharmaceutical, food, and cosmetic industries. Research has shown that fungi produce a variety of terpenoids, yet fungal terpene synthases remain not thoroughly explored. In this study, the gene, a crucial component of the terpene synthetic pathway, was isolated from HB20111 through genome mining.

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Obesity is a major public burden on the working population and induces chronic diseases. Its treatment often requires long-term medication, which makes patient compliance difficult. In this study, we reported the value of HORN-MN, which comprised a fast-soluble hyaluronic acid microneedle matrix and a weak acid-degradable oleanolic acid dimer of rosiglitazone nanoparticles.

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In eukaryotes, Hsp90B1 serves as a vital chaperonin, facilitating the accurate folding of proteins. Interestingly, Hsp90B1 exhibits contrasting roles in the development of various types of cancers, although the underlying reasons for this duality remain enigmatic. Through the utilization of the Drosophila model, this study unveils the functional significance of Gp93, the Drosophila ortholog of Hsp90B1, which hitherto had limited reported developmental functions.

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Objectives: Although clinicians may use methylene blue (MB) in refractory septic shock, the effect of MB on patient-important outcomes remains uncertain. We conducted a systematic review and meta-analysis to investigate the benefits and harms of MB administration in patients with septic shock.

Data Sources: We searched six databases (including PubMed, Embase, and Medline) from inception to January 10, 2024.

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Coral reef ecosystems have been severely ravaged by global warming and eutrophication. Eutrophication often originates from nitrogen (N) overloading that creates stoichiometric phosphorus (P) limitation, which can be aggravated by sea surface temperature rises that enhances stratification. However, how P-limitation interacts with thermal stress to impact coral-Symbiodiniaceae mutualism is poorly understood and underexplored.

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Organic small molecules are proven to be capable of passivating the bulk/interfacial defects in inorganic perovskite solar cells. Considering the burdensome situation to screen the functional small molecules, we employ a modified machine learning (ML) strategy to guide screening suitable small molecules toward efficient solar cells through three modified ML algorithms to construct the prediction model: (i) random forest algorithm (RF), (ii) support vector machine algorithm (SVR), and (iii) XGBoost. Among them, the XGBoost algorithm displays a better overall predictive performance, whereby the index reaches 0.

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Despite CsPbIBr inorganic perovskites exhibit high potential for single-junction and/or tandem solar cells, unexpected non-radiative recombination, and mismatched interfacial band alignment within the inorganic perovskite solar cells (PSCs) disadvantageously affect their photovoltaic performance. Rational design of the dipole shielding layer (DSL) is vital to realize a win-win situation for the defect passivation and band alignment. Herein, A-site dipole molecules, that is, neopentylamine and 2-methylbutylamine, are employed for in-situ self-assembly of a thus-far unreported DSL at the interface between 3D perovskite and hole transport layer.

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