Unlocking ABA's role in rice cold tolerance: insights from Zhonghua 11 and Kasalath.

Unraveling key ABA pathways, including OsWRKY71-OsABA8ox1 and OsbZIP73-OsNCED5, provides valuable insights for improving cold tolerance in rice breeding for cold-prone regions. Cold stress limits rice (Oryza sativa L.) production in cooler climates.

Drug-induced Spontaneous intramural hematoma of the gastrointestinal tract: A real-world pharmacovigilance analysis.

It is unclear whether drugs other than warfarin can cause spontaneous gastrointestinal intraluminal hematomas (SGIH). This study aimed to investigate the drugs that induced SGIH based on the FDA Adverse Event Reporting System (FAERS) data. A retrospective pharmacovigilance study was conducted.

Anxiety about artificial intelligence from patient and doctor-physician.

Objective: This paper investigates the anxiety surrounding the integration of artificial intelligence (AI) in doctor-patient interactions, analyzing the perspectives of both patients and healthcare providers to identify key concerns and potential solutions.

Methods: The study employs a comprehensive literature review, examining existing research on AI in healthcare, and synthesizes findings from various surveys and studies that explore the attitudes of patients and doctors towards AI applications in medical settings.

Results: The analysis reveals that patient anxiety encompasses algorithm aversion, robophobia, lack of humanistic care, challenges in human-machine interaction, and concerns about AI's universal applicability.

Quercetin rescues dihydrotestosterone-treated human dermal papilla cells via SHP2/AKT signaling to suppress autophagy and apoptosis.

The management of hair loss is vital in clinical dermatology due to its prevalence and impact on patients' quality of life. Quercetin is recognized for its diverse activities, including anti-inflammatory, anti-cancer, and immune regulation. However, its effects on human hair follicles and mechanisms remain unclear.

BioMedGraphica: An All-in-One Platform for Biomedical Prior Knowledge and Omic Signaling Graph Generation.

Artificial intelligence (AI) is revolutionizing scientific discovery because of its super capability, following the neural scaling laws, to integrate and analyze large-scale datasets to mine knowledge. Foundation models, large language models (LLMs) and large vision models (LVMs), are among the most important foundations paving the way for general AI by pre-training on massive domain-specific datasets. Different from the well annotated, formatted and integrated large textual and image datasets for LLMs and LVMs, biomedical knowledge and datasets are fragmented with data scattered across publications and inconsistent databases that often use diverse nomenclature systems in the field of AI for Precision Health and Medicine (AI4PHM).

Gender differences in self-rated health among older adults in the Chinese workforce.

Introduction: This study investigates gender-based disparities in self-rated health among older individuals in the Chinese workforce, utilizing data from the China Health and Retirement Longitudinal Study (CHARLS). Understanding these health gaps is crucial for crafting effective health policies and interventions in light of the rapidly aging population.

Materials And Methods: Data from the 2020 CHARLS survey, comprising Chinese individuals aged 45 and above, were analyzed, focusing on older adults actively employed.

Genetic susceptibility of diffuse large B-cell lymphoma: a meta genome-wide association study in Asian population.

Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy and the most common form of non-Hodgkin lymphoma (NHL) that occurs worldwide. To discover risk factors and pathogenesis of DLBCL, we performed the largest GWAS of DLBCL to date in samples of East Asian ancestry, consisting of 2,888 patients with DLBCL and 12,458 controls. The meta-analysis identified three novel loci, rs2233434 on 6p21.

STING orchestrates microglia polarization via interaction with LC3 in autophagy after ischemia.

Autophagy has both protective and pathogenetic effects on injury caused by cerebral ischemia/reperfusion (I/R). Our previous research has indicated that stimulator of interferon genes (STING) could orchestrate microglia polarization following middle cerebral artery occlusion. However, it remains largely unexplored whether STING balances microglial polarization by regulating autophagy in brain I/R injury.

Circadian Rhythm-Dependent Therapy by Composite Targeted Polyphenol Nanoparticles for Myocardial Ischemia-Reperfusion Injury.

Myocardial ischemia-reperfusion (IR) injury is a severe rhythmic disease with a high prevalence in the early morning. IR injury has a significant circadian rhythm in reactive oxygen species (ROS) and inflammation levels. The development of rhythmic drugs has become a priority in myocardial IR injury.

A Spatio-Temporal Capsule Neural Network with Self-Correlation Routing for EEG Decoding of Semantic Concepts of Imagination and Perception Tasks.

Decoding semantic concepts for imagination and perception tasks (SCIP) is important for rehabilitation medicine as well as cognitive neuroscience. Electroencephalogram (EEG) is commonly used in the relevant fields, because it is a low-cost noninvasive technique with high temporal resolution. However, as EEG signals contain a high noise level resulting in a low signal-to-noise ratio, it makes decoding EEG-based semantic concepts for imagination and perception tasks (SCIP-EEG) challenging.

Impact of Family Doctor Contract Services on Preventable Hospitalizations Amongst Patients with Hypertension in Rural China: Mediating Role of Primary Healthcare Quality.

Purpose: The objective of this study was to explore the connection between family doctor contract services and preventable hospitalizations. Additionally, we sought to examine the role of primary health care quality as a mediating factor in the link between family doctor contract services and preventable hospitalizations among patients with hypertension.

Patients And Methods: This cross-sectional study was performed in Dangyang (Hubei Province, Central China) and Xishui (Guizhou Province, Western China) counties in July-August 2023.

Decomposition of Forces in Protein: Methodology and General Properties.

In contrast to the central role played by the structure of biomolecules, the complementary force-based view has received little attention in past studies. Here, we proposed a simple method for the force decomposition of multibody interactions and provided some techniques to analyze and visualize the general behavior of forces in proteins. It was shown that atomic forces fluctuate at a magnitude of about 3000 pN, which is huge in the context of cell biology.

Application of artificial intelligence in lung cancer screening: A real-world study in a Chinese physical examination population.

Background: With the rapid increase of chest computed tomography (CT) images, the workload faced by radiologists has increased dramatically. It is undeniable that the use of artificial intelligence (AI) image-assisted diagnosis system in clinical treatment is a major trend in medical development. Therefore, in order to explore the value and diagnostic accuracy of the current AI system in clinical application, we aim to compare the detection and differentiation of benign and malignant pulmonary nodules between AI system and physicians, so as to provide a theoretical basis for clinical application.

The whole genome dataset of .

The classification of the Uranoscopidae species is controversial and the belonging to Uranoscopidae was first reported in 2019. In the present study the whole genome sequence of were generated by PacBio and Illumina platforms for the first time. After assembly and correction of the high-quality PacBio data, a 527.

Spatial-temporal pattern of ecosystem services and sustainable development in representative mountainous cities: A case study of Chengdu-Chongqing Urban Agglomeration.

The Sustainable Development Goals (SDGs) are essential measure for preserving the balance between human well-being and natural ecosystems. The benefit of preserving ecosystems health play a crucial role in promoting the SDGs by providing stable ecosystem services (ESs). However, the ecological health of mountainous cities is vulnerable, with relative low ecological resilience.

Integrated network pharmacology and GC-MS-based metabolomics to investigate the chemical profile and efficacy of Anemarrhenae Rhizoma and its processed products.

Rationale: Anemarrhenae Rhizoma (AR) has been a frequently utilized traditional Chinese medicine (TCM) for an extended period, with its salt-processed variant being a prevalent application form. Contemporary pharmacological investigations have demonstrated that the salt-processed iteration exhibits a multitude of markedly augmented pharmacological properties. However, whether the pharmacodynamic material basis of this change is related to volatile substances remains unclear.

Treatment outcomes of endoscopic resection for nonampullary duodenal neuroendocrine tumors.

Background: The incidence rate of duodenal neuroendocrine tumors has been increasing in recent years. Endoscopic resection [ER; endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD)] is recommended for nonampullary duodenal neuroendocrine tumors (NAD-NETs) ≤10 mm in diameter that are confined to the submucosal layer and without lymph node or distant metastasis. However, the efficacy and safety of and indications for EMR/ESD remain unclear.